The Nuclear Receptor Superfamily Has Undergone Extensive Proliferation and Diversification in Nematodes

Genome Research - Tập 9 Số 2 - Trang 103-120 - 1999
Ann E. Sluder1, Siuyien Wong Mathews2,3, David W. Hough4, Viravuth P. Yin4,5, Claude V. Maina4
1Department of Cellular Biology, University of Georgia, Athens, Georgia 30602 USA. [email protected]
2Biotechnology Facility, University of Hawaii at Manoa, Honolulu, Hawaii 96822 USA;
3Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, USA
4New England Biolabs, Beverly, Massachusetts 01915, USA
5University of Pennsylvania School of Medi-cine, 320 CRB, Philadelphia, Pennsylvania 19104 USA.

Tóm tắt

The nuclear receptor (NR) superfamily is the most abundant class of transcriptional regulators encoded in the Caenorhabditis elegans genome, with >200 predicted genes revealed by the screens and analysis of genomic sequence reported here. This is the largest number of NR genes yet described from a single species, although our analysis of available genomic sequence from the related nematode Caenorhabditis briggsae indicates that it also has a large number. Existing data demonstrate expression for 25% of theC. elegans NR sequences. Sequence conservation and statistical arguments suggest that the majority represent functional genes. An analysis of these genes based on the DNA-binding domain motif revealed that several NR classes conserved in both vertebrates and insects are also represented among the nematode genes, consistent with the existence of ancient NR classes shared among most, and perhaps all, metazoans. Most of the nematode NR sequences, however, are distinct from those currently known in other phyla, and reveal a previously unobserved diversity within the NR superfamily. In C. elegans, extensive proliferation and diversification of NR sequences have occurred on chromosome V, accounting for > 50% of the predicted NR genes.[The sequence data described in this paper have been submitted to the GenBank data library under accession nos.AF083222–AF083225 and AF083251–AF083234.]

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Genome Research

Tập 9 Số 2

103-120

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