The Molecular Genetics Of Crown Gall Tumorigenesis

Advances in Genetics - Tập 22 - Trang 209-283 - 1984
P.J.J. Hooykaas1, R.A. Schilperoort1
1Laboratory of Biochemistry, University of Leiden, Leiden, The Netherlands

Tài liệu tham khảo

Ackermann, 1977, Pflanzen aus Agrobacterium rhizogenes-tumoren an Nicotiana tabacum., Plant Sci. Lett., 8, 23, 10.1016/0304-4211(77)90167-5 Akiyoshi, 1983, Cytokinin-auxin balance in crown gall tumors is regulated by specific loci in the T-DNA., Proc. Natl. Acad. Sci. U.S.A., 80, 407, 10.1073/pnas.80.2.407 Albinger, 1977, Übertragung der Fähigkeit zur Wurzelinduktion von Agrobacterium rhizogenes auf A., Tumefaciens. Phytopathol. Z., 90, 306, 10.1111/j.1439-0434.1977.tb03250.x Alconero, 1980, Crown gall of peaches from Maryland, South Carolina and Tennessee and problems with biological control., Plant Dis., 64, 835, 10.1094/PD-64-835 Allen, 1974, Genus Agrobacterium., 264 Anand, 1977, Crown gall tumorigenesis in potato tuber tissue., Am. J. Bot., 64, 153, 10.1002/j.1537-2197.1977.tb15713.x Anderson, 1979, Host specificity in the genus Agrobacterium., Phytopathology, 69, 320, 10.1094/Phyto-69-320 Banerjee, 1981, Cell surface carbohydrates of Agrobacterium tumefaciens involved in adherence during crown gall tumor initiation., Biochem. Biophys. Res. Commun., 100, 1384, 10.1016/0006-291X(81)91977-X Barnes, 1977, Plasmid detection and sizing in single colony lysates., Science, 195, 393, 10.1126/science.318764 Beardsley, 1960, Lysogenicity in A., Tumefaciens. J. Bacteriol., 80, 180, 10.1128/JB.80.2.180-187.1960 Beiderbeck, 1973, Wurzelinduktion an Blättern von Kalanchöe daigremontiana durch Agrobacterium rhizogenes und der Einfluss von Kinetin auf diesen Prozess., Z. Pflanzenphysiol., 68, 460, 10.1016/S0044-328X(73)80113-8 Beiderbeck, 1973, Unabhängige Induktion von Teratomen und Wurzeln durch Mischungen verschiedener Stämme von Agrobacterium., Z. Pflanzenphysiol., 69, 163, 10.1016/S0044-328X(73)80033-9 Beringer, 1978, Transfer of the drug-resistance transposon Tn5 to Rhizobium., Nature (London), 276, 633, 10.1038/276633a0 Bernaerts, 1963, A biochemical test for crown gall bacteria., Nature (London), 197, 406, 10.1038/197406b0 Bezděk, 1976, Properties of the cured oncogenic strain 37400 of Agrobacterium tumefaciens., Folia Microbiol., 21, 371, 10.1007/BF02876963 Biemann, 1960, Sur la structure chimique de la lysopine, nouvel acide aminé isolé de tissu de crown-gall., Bull. Soc. Chim. Biol., 42, 979 Binns, 1981, Suppression of the tumorous state in crown gall teratomas of tobacco. A clonal analysis., Differentiation, 19, 97, 10.1111/j.1432-0436.1981.tb01135.x Bomhoff, 1976, Octopine and nopaline synthesis and breakdown genetically controlled by a plasmid of Agrobacterium tumefaciens., Mol. Gen. Genet., 145, 177, 10.1007/BF00269591 Bopp, 1966, Crown-gall-tumoren bei Verschiedenen Arten und Bastarden der Kalanchoideae., Port. Acta Biol., 9, 327 Boucher, 1977, Introduction of bacteriophage Mu into Pseudomonas solanacearum and Rhizobium meliloti using R factor RP4., J. Gen. Microbiol., 98, 253, 10.1099/00221287-98-1-253 Boyd, 1970, Specificity patterns of Agrobacterium tumefaciens phages., Arch. Mikrobiol., 73, 324, 10.1007/BF00412299 Braun, 1943, Studies on tumor inception in the crown-gall disease., Am. J. Bot., 30, 674, 10.1002/j.1537-2197.1943.tb10317.x Braun, 1947, Thermal studies on the factors responsible for tumor initiation in crown gall., Am. J. Bot., 34, 234, 10.1002/j.1537-2197.1947.tb12981.x Braun, 1948, Studies on the origin and development of plant teratomas incited by the crown-gall bacterium., Am. J. Bot., 35, 511, 10.1002/j.1537-2197.1948.tb08114.x Braun, 1951, Recovery of crown-gall tumor cells., Cancer Res., 11, 839 Braun, 1953, Bacterial and host factors concerned in determining tumor morphology in crown gall., Bot. Gaz., 114, 363, 10.1086/335780 Braun, 1958, A physiological basis for autonomous growth of crown gall tumor cell., Proc. Natl. Acad. Sci. U.S.A., 44, 344, 10.1073/pnas.44.4.344 Braun, 1959, A demonstration of the recovery of the crown gall tumor cell with the use of complex tumors of single-cell origin., Proc. Natl. Acad. Sci. U.S.A., 45, 932, 10.1073/pnas.45.7.932 Braun, 1976, Suppression of the neoplastic state with the acquisition of specialized functions in cells, tissues, and organs of crown gall teratomas of tobacco., Proc. Natl. Acad. Sci. U.S.A., 73, 496, 10.1073/pnas.73.2.496 Bruch, 1957, Host specificities of four Lotus rhizobiophages., Can. J. Microbiol., 3, 181, 10.1139/m57-022 Bryan, 1982, R68.45 mediated chromosomal gene transfer in Agrobacterium tumefaciens., Arch. Microbiol., 131, 271, 10.1007/BF00405892 Casse, 1979, Identification and characterization of large plasmids in Rhizobium meliloti using agarose gel electrophoresis., J. Gen. Microbiol., 113, 229, 10.1099/00221287-113-2-229 Chern, 1976, Dependency of glucose transport on d-glucoside 3-dehydrogenase as a conversion system of glucose to 3-ketoglucose in Agrobacterium tumefaciens., Agric. Biol. Chem., 40, 2299 Chilton, 1980, Agrobacterium Ti plasmids as a tool for genetic engineering in plants., 23 Chilton, 1976, RP4 promotion of transfer of a large Agrobacterium plasmid which confers virulence., Genetics, 83, 609, 10.1093/genetics/83.4.609 Chilton, 1977, Stable incorporation of plasmid DNA into higher plant cells: The molecular basis of crown gall tumorigenesis., Cell, 11, 263, 10.1016/0092-8674(77)90043-5 Chilton, 1978, Restriction endonuclease mapping of a plasmid that confers oncogenicity upon Agrobacterium tumefaciens strain B6–806., Plasmid, 1, 254, 10.1016/0147-619X(78)90043-4 Chilton, 1978, Highly conserved DNA of Ti-plasmids overlaps T-DNA maintained in plant tumors., Nature (London), 275, 147, 10.1038/275147a0 Chilton, 1980, T-DNA from Agrobacterium Ti plasmid is in the nuclear DNA fraction of crown gall tumor cells., Proc. Natl. Acad. Sci. U.S.A., 77, 4060, 10.1073/pnas.77.7.4060 Chilton, 1982, Agrobacterium rhizogenes inserts T-DNA into plant roots., Nature (London), 295, 432, 10.1038/295432a0 Clark, 1972, A comparison of the properties of Agrobacterium tumefaciens with those of other phytopathogens, symbionts and saprophytes., Phytopathol. Z., 74, 74, 10.1111/j.1439-0434.1972.tb04648.x Clark, 1974, Indole acetic acid production by Agrobacterium and Rhizobium species., Microbios, 11A, 29 Clewell, 1969, Supercoiled circular DNA-protein complex in E. coli: Purification and induced conversion to an open circular DNA form., Proc. Natl. Acad. Sci. U.S.A., 62, 1159, 10.1073/pnas.62.4.1159 Colak, 1979, Die Übertragung der Fähigkeit zur Tumorinduktion von Agrobacterium tumefaciens auf A., Rhizogenes. Phytopath. Z., 96, 268, 10.1111/j.1439-0434.1979.tb01649.x Colbère-Garapin, 1981, A new dominant hybrid selective marker for higher eukaryotic cells., J. Mol. Biol., 150, 1, 10.1016/0022-2836(81)90321-1 Cole, 1973, Transmissible resistance to penicillin G, neomycin, and chloramphenicol in Rhizobium japonicum., Antimicrob. Agents Chemother., 4, 248, 10.1128/AAC.4.3.248 Conn, 1945, The value of bacteriophage in classifying certain soil bacteria., J. Bacteriol., 49, 359, 10.1128/JB.49.4.359-373.1945 Cooksey, 1980, Biological control of crown gall with fungal and bacterial antagonists., Phytopathology, 70, 506, 10.1094/Phyto-70-506 Cooksey, 1980, An agrocin mutant of Agrobacterium radiobacter K84 and biological control of crown gall., Phytopathology, 71, 104 Cooksey, 1982, High frequency spontaneous mutations to agrocin 84 resistance in Agrobacterium tumefaciens and A., Rhizogenes. Physiol. Plant Pathol., 20, 129, 10.1016/0048-4059(82)90078-9 Costantino, 1980, Tumor formation and rhizogenicity of Agrobacterium rhizogenes carrying Ti plasmids., Gene, 11, 79, 10.1016/0378-1119(80)90088-8 Costantino, 1981, Fingerprinting and sequence homology of plasmids form different virulent strains of Agrobacterium rhizogenes., Plasmid, 5, 170, 10.1016/0147-619X(81)90018-4 Currier, 1976, Isolation of covalently closed circular DNA of high molecular weight from bacteria., Anal. Biochem., 66, 431, 10.1016/0003-2697(76)90338-9 Currier, 1976, Evidence for diverse types of large plasmids in tumor-inducing strains of Agrobacterium., J. Bacteriol., 126, 157, 10.1128/JB.126.1.157-165.1976 Datta, 1972, Host ranges of R factors., J. Gen. Microbiol., 70, 453, 10.1099/00221287-70-3-453 De Beuckeleer, 1981, Further insight on the transferred-DNA of octopine crown gall., Mol. Gen. Genet., 183, 283, 10.1007/BF00270630 De Cleene, 1977, The host range of crown gall., Bot. Rev., 42, 389, 10.1007/BF02860827 De Greve, 1981, The functional organization of the octopine Agrobacterium tumefaciens plasmid pTiB6S3., Plasmid, 6, 235, 10.1016/0147-619X(81)90069-X De Picker, 1978, Homologous DNA sequences in different Ti plasmids are essential for oncogenicity., Nature (London), 275, 150, 10.1038/275150a0 De Picker, 1980, IS-like element IS8 in RP4 plasmid and its involvement in cointegration., Gene, 10, 329, 10.1016/0378-1119(80)90153-5 De Picker, 1980, Molecular cloning of overlapping segments of the nopaline Ti-plasmid pTiC58 as a means to restriction endonuclease mapping., Plasmid, 3, 193, 10.1016/0147-619X(80)90109-2 De Vos, 1981, Restriction endonuclease mapping of the octopine tumor-inducing plasmid pTiAch5 of Agrobacterium tumefaciens., Plasmid, 6, 249, 10.1016/0147-619X(81)90070-6 Dhanvantari, 1978, Characterization of Agrobacterium isolates from stone fruits in Ontario., Can. J. Bot., 56, 2309, 10.1139/b78-278 Douglas, 1979, Early detection of octopine in crown-gall tumors of Jerusalem artichoke., Plant Sci. Lett., 15, 89, 10.1016/0304-4211(79)90099-3 Draper, 1982, Ti plasmid homologous sequences present in tissues from Agrobacterium plasmid-transformed Petunia protoplasts., Plant Cell Physiol., 23, 451, 10.1093/oxfordjournals.pcp.a076368 Drummond, 1978, Tumor-inducing (Ti) plasmids of Agrobacterium share extensive regions of DNA homology., J. Bacteriol., 136, 1178, 10.1128/JB.136.3.1178-1183.1978 Drummond, 1977, Foreign DNA of bacterial plasmid origin is transcribed in crown gall tumours., Nature (London), 269, 535, 10.1038/269535a0 Dulbecco, 1979, Contributions of microbiology to eucaryotic cell biology: New directions for microbiology., Microbiol. Rev., 43, 443, 10.1128/MMBR.43.4.443-452.1979 Eckhardt, 1978, A rapid method for the identification of plasmid deoxyribonucleic acid in bacteria., Plasmid, 1, 584, 10.1016/0147-619X(78)90016-1 El-Fiki, 1981, Agrobacterium tumefaciens in agriculture and research., Int. Rev. Cytol., 13, 47 Ellis, 1981, Four new opines from crown gall tumours—their detection and properties., Mol. Gen. Genet., 181, 36, 10.1007/BF00339002 Ellis, 1979, Arginine catabolism: A new function of both octopine and nopaline Ti-plasmids of Agrobacterium., Mol. Gen. Genet., 173, 263, 10.1007/BF00268636 Ellis, 1982, Conjugal transfer of nopaline and agropine Ti-plasmids. The role of agrocinopines., Mol. Gen. Genet., 186, 269, 10.1007/BF00331861 Ellis, 1982, Isolation and properties of transfer regulatory mutants of the nopaline Ti-plasmid pTiC58., Mol. Gen. Genet., 186, 275, 10.1007/BF00331862 Engler, 1975, Agrocin 84 sensitivity: A plasmid determined property in Agrobacterium tumefaciens., Mol. Gen. Genet., 138, 345, 10.1007/BF00264804 Engler, 1981, Physical mapping of DNA base sequence homologies between an octopine and a nopaline Ti-plasmid of Agrobacterium tumefaciens., J. Mol. Biol., 152, 183, 10.1016/0022-2836(81)90239-4 Expert, 1982, ψ, a temperate phage of Agrobacterium tumefaciens, is mutagenic., J. Virol., 42, 283, 10.1128/JVI.42.1.283-291.1982 Expert, 1982, The state of phage ψ DNA in lysogenic cells of Agrobacterium tumefaciens., Virology, 121, 82, 10.1016/0042-6822(82)90119-2 Farrand, 1981, Suppression of tumorigenicity by the inc W R-plasmid pSa in Agrobacterium tumefaciens., Mol. Gen. Genet., 181, 44, 10.1007/BF00339003 Firmin, 1977, N2-(1, 3 dicarboxypropyl) ornithine in crown gall tumours., Phytochemistry, 16, 761, 10.1016/S0031-9422(00)89249-3 Firmin, 1978, Agropine—a major new plasmid-determined metabolite in crown gall tumours., Nature (London), 276, 842, 10.1038/276842a0 Galsky, 1980, Crown gall tumor disc bioassay. A possible aid in the detection of compounds with antitumor activity., Plant Physiol., 65, 184, 10.1104/pp.65.2.184 Galsky, 1981, Crown gall tumors possess tumor-specific antigenic sites on their cell walls., Plant Physiol., 67, 1195, 10.1104/pp.67.6.1195 Garfinkel, 1980, Agrobacterium tumefaciens mutants affected in crown gall tumorigenesis and octopine catabolism., J. Bacteriol., 144, 732, 10.1128/JB.144.2.732-743.1980 Garfinkel, 1981, Genetic analysis of crown gall: Fine structure map of the T-DNA by site-directed mutagenesis., Cell, 27, 143, 10.1016/0092-8674(81)90368-8 Gelvin, 1981, Transcription of the Agrobacterium Ti-plasmid in the bacterium and in crown gall tumors., Plasmid, 6, 17, 10.1016/0147-619X(81)90051-2 Gelvin, 1982, Sizes and map positions of several plasmid DNA-encoded transcripts in octopine-type crown gall tumors., Proc. Natl. Acad. Sci. U.S.A., 79, 76, 10.1073/pnas.79.1.76 Genetello, 1977, The Ti-plasmids of Agrobacterium as conjugative plasmids., Nature (London), 265, 561, 10.1038/265561a0 Glogowski, 1978, Agrobacterium tumefaciens site attachment as a necessary prerequisite for crown gall tumor formation on potato disks., Plant Physiol., 61, 1031, 10.1104/pp.61.6.1031 Goldmann, 1977, Octopine and nopaline dehydrogenases in crown-gall tumors., Plant Sci. Lett., 10, 49, 10.1016/0304-4211(77)90049-9 Goldmann, 1969, Sur la structure de la nopaline, métabolite anormale de certaines tumeurs de crown gall., C. R. Acad. Sci. Paris, 268, 852 Graham, 1964, The application of computer techniques to the taxonomy of root-nodule bacteria of legumes., J. Gen. Microbiol., 35, 511, 10.1099/00221287-35-3-511 Gresshoff, 1979, Crown gall teratoma formation is plasmid and plant controlled., J. Bacteriol., 137, 1020, 10.1128/JB.137.2.1020-1021.1979 Grindley, 1973, Molecular studies of R factor compatibility groups., J. Bacteriol., 115, 387, 10.1128/JB.115.1.387-398.1973 Gurley, 1979, Transcription of Ti-plasmid-derived sequences in the octopine-type crown gall tumor lines., Proc. Natl. Acad. Sci. U.S.A., 76, 2828, 10.1073/pnas.76.6.2828 Guyon, 1980, Agropine in “null-type” crown gall tumors: Evidence for generality of the opine concept., Proc. Natl. Acad. Sci. U.S.A., 77, 2693, 10.1073/pnas.77.5.2693 Hack, 1977, Comparison of octopine, histopine, lysopine and octopinic acid synthesizing activities in sunflower crown gall tissues., Biochem. Biophys. Res. Commun., 78, 785, 10.1016/0006-291X(77)90248-0 Hamada, 1979, R-plasmid-mediated chromosomal gene transfer in Agrobacterium tumefaciens., J. Bacteriol., 139, 280, 10.1128/JB.139.1.280-286.1979 Hamilton, 1975, Transfer of the tumor inducing factor in Agrobacterium tumefaciens., Biochem. Biophys. Res. Commun., 63, 349, 10.1016/S0006-291X(75)80050-7 Hamilton, 1971, The loss of tumor-initiating ability in Agrobacterium tumefaciens by incubation at high temperature., Experientia, 27, 229, 10.1007/BF02145913 Hansen, 1978, Isolation of large bacterial plasmids and characterization of the P2 incompatibility group plasmids pMG1 and pMG5., J. Bacteriol., 135, 227, 10.1128/JB.135.1.227-238.1978 Harth, 1982, Amplification of a specific Ti-plasmid sequence in mammalian cells as circular DNA after transfection with Ti plasmid of Agrobacterium tumefaciens., Zentralbl. Bakteriol., 253, 18 Hepburn, 1979, Regions of DNA sequence homology between an octopine and a nopaline Ti-plasmid of Agrobacterium tumefaciens., Mol. Gen. Genet., 169, 163, 10.1007/BF00271667 Hernalsteens, 1977, Transposition of Tn1 to a broad-host-range drug resistance plasmid., 179 Hernalsteens, 1978, Mutagenesis by insertion of the drug resistance transposon Tn7 applied to the Ti-plasmid of Agrobacterium tumefaciens., Plasmid, 1, 218, 10.1016/0147-619X(78)90040-9 Hernalsteens, 1980, The Agrobacterium tumefaciens Ti-plasmid as a host vector system for introducing foreign DNA in plant cells., Nature (London), 287, 654, 10.1038/287654a0 Hille, 1981, Behavior of incQ plasmids in Agrobacterium tumefaciens., Plasmid, 6, 360, 10.1016/0147-619X(81)90045-7 Hille, 1981, The use of transposons to introduce well-defined deletions in plasmids: Possibilities for in vivo cloning., Plasmid, 6, 151, 10.1016/0147-619X(81)90062-7 Hille, 1982, Construction and application of R prime plasmids, carrying different segments of an octopine Ti-plasmid from Agrobacterium tumefaciens for complementation of vir genes., Plasmid, 7, 107, 10.1016/0147-619X(82)90071-3 Hille, 1983, Site-directed mutagenesis in Escherichia coli of a stable R772:Ti cointegrate from Agrobacterium tumefaciens., J. Bacteriol., 154, 693, 10.1128/JB.154.2.693-701.1983 Holsters, 1978, In vivo transfer of the Ti-plasmid of Agrobacterium tumefaciens to Escherichia coli., Mol. Gen. Genet., 163, 335, 10.1007/BF00271963 Holsters, 1978, Spontaneous formation of cointegrates of the oncogenic Ti-plasmid and the wide-host-range P-plasmid RP4., Plasmid, 1, 456, 10.1016/0147-619X(78)90004-5 Holsters, 1978, Transfection and transformation of Agrobacterium tumefacciens., Mol. Gen. Genet., 163, 181, 10.1007/BF00267408 Holsters, 1980, The functional organization of the nopaline A. tumefaciens plasmid pTiC58., Plasmid, 3, 212, 10.1016/0147-619X(80)90110-9 Holsters, 1982, The use of selectable markers for the isolation of plant DNA/T-DNA junction fragments in a cosmid vector., Mol. Gen. Genet., 185, 283, 10.1007/BF00330799 Hooykaas, P. J. J. (1979). “The role of plasmid determined functions in the interactions of Rhizobiaceae with plant cells. A genetic approach.” Ph.D. thesis, Leiden University. Hooykaas, 1977, Transfer of the Agrobacterium tumefaciens Ti-plasmid to avirulent agrobacteria and to Rhizobium ex planta., J. Gen. Microbiol., 98, 477, 10.1099/00221287-98-2-477 Hooykaas, 1979, Agrobacterium tumor inducing plasmids: Potential vectors for the genetic engineering of plants., 1, 151 Hooykaas, 1979, Regulation of the transfer of Ti-plasmids of Agrobacterium tumefaciens., J. Gen. Microbiol., 110, 99, 10.1099/00221287-110-1-99 Hooykaas, 1980, Molecular mechanism of Ti-plasmid mobilization by R-plasmids. Isolation of Ti-plasmids with transposon-insertions in Agrobacterium tumefaciens., Plasmid, 4, 65, 10.1016/0147-619X(80)90083-9 Hooykaas, 1980, Interactions between octopine and nopaline plasmids in Agrobacterium tumefaciens., J. Bacteriol., 143, 1295, 10.1128/JB.143.3.1295-1306.1980 Hooykaas, 1981, Sym plasmid of Rhizobium trifolii expressed in different rhizobial species and Agrobacterium tumefaciens., Nature (London), 291, 351, 10.1038/291351a0 Hooykaas, 1982, Tumors induced by different strains of Agrobacterium tumefaciens., 373 Hooykaas, 1982, Method for the transfer of large cryptic, non-self-transmissible plasmids: ex planta transfer of the virulence plasmid of Agrobacterium rhizogenes., Plasmid, 8, 94, 10.1016/0147-619X(82)90046-4 Hooykaas, 1982, A chromosomal linkage map of Agrobacterium tumefaciens and a comparison with the maps of Rhizobium spp., Mol. Gen. Genet., 188, 12, 10.1007/BF00332990 Hooykaas, 1982, Identification of the Sym plasmid of Rhizobium leguminosarum strain 1001 and its transfer to and expression in other rhizobia and Agrobacterium tumefaciens., Plasmid, 8, 73, 10.1016/0147-619X(82)90042-7 Hooykaas, 1982, Phenotypic expression of mutations in a wide-host range R plasmid in Escherichia coli and Rhizobium meliloti., J. Bacteriol., 150, 395, 10.1128/JB.150.1.395-397.1982 Howell, 1982, Plant molecular vehicles: Potential vectors for introducing foreign DNA into plants., Annu. Rev. Plant Physiol., 33, 609, 10.1146/annurev.pp.33.060182.003141 Huff, 1981, Neoplastic potential of trichomes isolated from tobacco crown gall teratomas., Differentiation, 19, 93, 10.1111/j.1432-0436.1981.tb01134.x Jaynes, 1981, The position of Agrobacterium rhizogenes., Int. Rev. Cytol., 13, 105 Kado, 1981, Rapid procedure for detection and isolation of large and small plasmids., J. Bacteriol., 145, 1365, 10.1128/JB.145.3.1365-1373.1981 Kaiss-Chapman, 1977, Trans-zeatin in culture filtrates of Agrobacterium tumefaciens., Biochem. Biophys. Res. Commun., 76, 453, 10.1016/0006-291X(77)90746-X Kartašova, 1981, A coupled transcription-translation system from Agrobacterium tumefaciens and its application to study Ti-plasmid expression in vitro., Nucleic Acids Res., 9, 6763, 10.1093/nar/9.24.6763 Keane, 1970, Crown gall of stone fruit. II. Identification and nomenclature of Agrobacterium isolates., Aust. J. Biol. Sci., 23, 585, 10.1071/BI9700585 Kemp, 1977, A new amino acid derivative present in crown gall tumor tissue., Biochem. Biophys. Res. Commun., 74, 862, 10.1016/0006-291X(77)91598-4 Kennedy, 1980, Estimates of USA crop losses to prokaryotic plant pathogens., Plant Dis., 64, 674, 10.1094/PD-64-674 Kerr, 1969, Transfer of virulence between isolates of Agrobacterium., Nature (London), 223, 1175, 10.1038/2231175a0 Kerr, 1971, Acquisition of virulence by non-pathogenic isolates of Agrobacterium radiobacter., Physiol. Plant Pathol., 1, 241, 10.1016/0048-4059(71)90045-2 Kerr, 1972, Biological control of crown gall: Seed inoculation., J. Appl. Bacteriol., 35, 493, 10.1111/j.1365-2672.1972.tb03727.x Kerr, 1980, Biological control of crown gall through production of agrocin 84., Plant Dis., 64, 25 Kerr, 1974, Biological control of crown gall through bacteriocin production., Physiol. Plant Pathol., 4, 37, 10.1016/0048-4059(74)90042-3 Kerr, 1977, Biotypes of Agrobacterium radiobacter var. tumefaciens and their biological control., Phytopathol. Z., 90, 172, 10.1111/j.1439-0434.1977.tb03233.x Kerr, 1976, Agrobacterium: Correlations between and transfer of pathogenicity, octopine and nopaline metabolism and bacteriocin 84 sensitivity., Physiol. Plant Pathol., 9, 205, 10.1016/0048-4059(76)90041-2 Kerr, 1977, Transfer of virulence in vivo and in vitro in Agrobacterium., Nature (London), 265, 560, 10.1038/265560a0 Kersters, 1973, Numerical taxonomic analysis of Agrobacterium., J. Gen. Microbiol., 78, 227, 10.1099/00221287-78-2-227 Klapwijk, P. M. (1979). “The role of octopine in conjugation and plant tumor formation by Agrobacterium tumefaciens. Studies on tumour-inducing plasmids.” Ph.D. thesis, Leiden University. Klapwijk, 1979, Negative control of octopine degradation and transfer genes of octopine Ti-plasmids in Agrobacterium tumefaciens., J. Bacteriol., 139, 424, 10.1128/JB.139.2.424-431.1979 Klapwijk, 1982, Genetic determination of octopine degradation., 475 Klapwijk, 1975, An enrichment technique for auxotrophs of Agrobacterium tumefaciens using a combination of carbenicillin and lysozyme., J. Gen. Microbiol., 91, 177, 10.1099/00221287-91-1-177 Klapwijk, 1976, Isolation and characterization of Agrobacterium tumefaciens mutants affected in the utilization of octopine, octopinic acid and lysopine., J. Gen. Microbiol., 96, 155, 10.1099/00221287-96-1-155 Klapwijk, 1977, Inducible permease involved in the uptake of octopine, lysopine, and octopinic acid by Agrobacterium tumefaciens strains carrying virulence-associated plasmids., J. Gen. Microbiol., 107, 1, 10.1099/00221287-102-1-1 Klapwijk, 1978, Coordinated regulation of octopine degradation and conjugative transfer of Ti-plasmids in Agrobacterium tumefaciens: Evidence for a common regulatory gene and separate operons., J. Bacteriol., 136, 775, 10.1128/JB.136.2.775-785.1978 Klapwijk, 1979, Isolation of a recombination deficient Agrobacterium tumefaciens mutant., Mol. Gen. Genet., 173, 171, 10.1007/BF00330307 Klapwijk, 1980, Transposition of Tn904 encoding streptomycin resistance into the octopine Ti-plasmid of Agrobacterium tumefaciens., J. Bacteriol., 141, 129, 10.1128/JB.141.1.129-136.1980 Klee, 1982, Complementation analysis of Agrobacterium tumefaciens Ti-plasmid mutations affecting oncogenicity., J. Bacteriol., 150, 327, 10.1128/JB.150.1.327-331.1982 Klein, 1955, A quantitative bioassay for crown-gall tumor formation., Am. J. Bot., 42, 709, 10.1002/j.1537-2197.1955.tb10411.x Knauf, 1982, Wide host range cloning vectors: A cosmid clone bank of an Agrobacterium Ti-plasmid., Plasmid, 8, 45, 10.1016/0147-619X(82)90040-3 Koekman, 1979, Genetic map of an octopine Ti-plasmid., Plasmid, 2, 347, 10.1016/0147-619X(79)90018-0 Koekman, 1980, Localization of the replication control region on the physical map of the octopine Ti-plasmid., Plasmid, 4, 184, 10.1016/0147-619X(80)90008-6 Koekman, 1982, A functional map of the replicator region of the octopine Ti-plasmid., Plasmid, 7, 119, 10.1016/0147-619X(82)90072-5 Krens, 1982, In vitro transformation of plant protoplasts with Ti-plasmid DNA., Nature (London), 296, 72, 10.1038/296072a0 Kurkdjian, 1974, The pea seedling as a model of normal and abnormal morphogenesis., Am. Biol. Teach., 36, 13, 10.2307/4444601 Langley, 1972, Studies on Agrobacterium tumefaciens. Conditions for mutagenesis by N-methyl-N'-nitro-N-nitrosoguanidine and relationships of A. tumefaciens mutants to crown gall tumor induction., Mutat. Res., 14, 277, 10.1016/0027-5107(72)90014-0 Ledeboer, A. M. (1978). “Large plasmids in Rhizobiaceae. Studies on the transcription of the tumour inducing plasmid from Agrobacterium tumefaciens in sterile crown gall tumour cells.” Ph.D. thesis, University of Leiden. Ledeboer, 1976, On the isolation of Ti plasmid from Agrobacterium tumefaciens., Nucleic Acids Res., 3, 449, 10.1093/nar/3.2.449 Leemans, 1981, Site-specific mutagenesis of Agrobacterium Ti plasmids and transfer of genes to plant cells., J. Mol. Appl. Genet., 1, 149 Leemans, 1982, Genetic identification of functions of t1-DNA transcripts in octopine crown galls., EMBO J., 1, 147, 10.1002/j.1460-2075.1982.tb01138.x Lemmers, 1980, Internal organization, boundaries and integration of Ti-plasmid DNA in nopaline crown gall tumours., J. Mol. Biol., 144, 353, 10.1016/0022-2836(80)90095-9 Lin, 1977, Studies on Agrobacterium tumefaciens VII. Avirulence induced by temperature and ethidium bromide., Can. J. Microbiol., 23, 1554, 10.1139/m77-229 Lipetz, 1966, Crown gall tumorigenesis II. Relations between wound healing and the tumorigenic response., Cancer Res., 26, 1597 Lippincott, 1965, The induction of leaf tumors by Agrobacterium tumefaciens., Am. J. Bot., 52, 396, 10.1002/j.1537-2197.1965.tb06800.x Lippincott, 1969, Bacterial attachment to a specific wound site as an essential stage in tumor initiation by Agrobacterium tumefaciens., J. Bacteriol., 97, 620, 10.1128/JB.97.2.620-628.1969 Lippincott, 1970, Enhanced tumor initiation by mixtures of tumorigenic and nontumorigenic strains of Agrobacterium., Infect. Immun., 2, 623, 10.1128/IAI.2.5.623-630.1970 Lippincott, 1978, Cell walls of crown-gall tumors and embryonic plant tissues lack Agrobacterium adherence sites., Science, 199, 1075, 10.1126/science.199.4333.1075 Lippincott, 1978, Tumor initiation complementation on bean leaves by mixtures of tumorigenic and nontumorigenic Agrobacterium rhizogenes., Phytopathology, 68, 365, 10.1094/Phyto-68-365 Lippincott, 1980, Microbial adherence in plants., Recept. Recognition Ser. B, 6, 377 Lippincott, 1977, Plasmid content and tumor initiation complementation by Agrobacterium tumefaciens IIBNV6., J. Bacteriol., 132, 824, 10.1128/JB.132.3.824-831.1977 Liu, 1979, Indoleacetic acid production: A plasmid function of Agrobacterium tumefaciens C58., Biochem. Biophys. Res. Commun., 90, 171, 10.1016/0006-291X(79)91605-X Liu, 1982, Agrobacterium Ti-plasmid indoleacetic acid gene is required for crown gall oncogenesis., Proc. Natl. Acad. Sci. U.S.A., 79, 2812, 10.1073/pnas.79.9.2812 Loper, 1979, Host range conferred by the virulence-specifying plasmid of Agrobacterium tumefaciens., J. Bacteriol., 139, 591, 10.1128/JB.139.2.591-596.1979 McPherson, 1980, Proteins encoded by Agrobacterium tumefaciens Ti-plasmid DNA (T-DNA) in crown gall tumors., Proc. Natl. Acad. Sci. U.S.A., 77, 2666, 10.1073/pnas.77.5.2666 Marton, 1979, In vitro transformation of cultured cells from Nicotiana tabacum by Agrobacterium tumefaciens., Nature (London), 277, 129, 10.1038/277129a0 Matthysse, 1978, Plasmid-dependent attachment of Agrobacterium tumefaciens to plant tissue culture cells., Infect. Immun., 22, 516, 10.1128/IAI.22.2.516-522.1978 Matthysse, 1981, Elaboration of cellulose fibrils by Agrobacterium tumefaciens during attachment to carrot cells., J. Bacteriol., 145, 583, 10.1128/JB.145.1.583-595.1981 Matzke, 1981, Site-specific insertion of genes into T-DNA of the Agrobacterium tumor-inducing plasmid: An approach to genetic engineering of higher plant cells., J. Mol. Appl. Genet., 1, 39 Memelink, 1983, Nopaline T-DNA is maintained during regeneration and generative propagation of transformed tobacco plants., Mol. Gen. Genet., 190, 516, 10.1007/BF00331085 Ménagé, 1964, Sur la présence d'octopine dans les tissues de crown-gall., C. R. Acad. Sci. Paris Ser. D, 259, 4795 Ménagé, 1965, Sur la présence d'un acide aminé nouveau dans le tissu de crown-gall., C. R. Soc. Biol., 159, 561 Merlo, 1977, Plasmids in avirulent strains of Agrobacterium., J. Bacteriol., 129, 76, 10.1128/JB.129.1.76-80.1977 Milani, 1972, Transfection in A., Tumefaciens. J. Virol., 10, 17, 10.1128/JVI.10.1.17-22.1972 Miller, 1974, Ribosyl-trans-zeatin, a major cytokinin produced by crown gall tumor tissue., Proc. Natl. Acad. Sci. U.S.A., 71, 334, 10.1073/pnas.71.2.334 Mitter, 1980, Symptomausprägung an Catharanthus-sprossen nach Infektion mit Agrobacterium rhizogenes., Z. Pflanzenphysiol., 100, 311, 10.1016/S0044-328X(80)80235-2 Montoya, 1977, Octopine and nopaline metabolism in Agrobacterium tumefaciens and crown gall tumor cells: Role of plasmid genes., J. Bacteriol., 129, 101, 10.1128/JB.129.1.101-107.1977 Montoya, 1978, Multiple genes coding for octopine-degrading enzymes in Agrobacterium., J. Bacteriol., 136, 909, 10.1128/JB.136.3.909-915.1978 Moore, 1981, Biology of Agrobacterium tumefaciens: Plant interactions., Int. Rev. Cytol., 13, 15 Moore, 1979, Involvement of a plasmid in the hairy root-disease of plants caused by Agrobacterium rhizogenes., Plasmid, 2, 617, 10.1016/0147-619X(79)90059-3 Munnecke, 1963, Hairy root (Agrobacterium rhizogenes) of field roses., Phytopathology, 53, 788 Murai, 1982, T-DNA of pTi15955 from Agrobacterium tumefaciens is transcribed into a minimum of seven polyadenylated RNAs in a sunflower crown gall tumor., Nucleic Acids Res., 10, 1679, 10.1093/nar/10.5.1679 Murai, 1982, Octopine synthase messenger RNA isolated from sunflower crown gall callus is homologous to the Ti-plasmid of Agrobacterium tumefaciens., Proc. Natl. Acad. Sci. U.S.A., 79, 86, 10.1073/pnas.79.1.86 Murooka, 1979, Expansion of the host range of coliphage P1 and gene transfer from enteric bacteria to other gram-negative bacteria., Appl. Environ. Microbiol., 38, 754, 10.1128/AEM.38.4.754-757.1979 Murooka, 1981, Introduction of bacteriophage Mu into bacteria of various genera and intergeneric gene transfer by RP4:Mu., J. Bacteriol., 145, 358, 10.1128/JB.145.1.358-368.1981 Murphy, 1979, A basis for agrocin 84 sensitivity in Agrobacterium radiobacter., J. Gen. Microbiol., 114, 207, 10.1099/00221287-114-1-207 Murphy, 1981, Substituents at N6 and C-5' control selective uptake and toxicity of the adenine-nucleotide bacteriocin, agrocin 84, in agrobacteria., Eur. J. Biochem., 115, 539, 10.1111/j.1432-1033.1981.tb06236.x New, 1971, A selective medium for Agrobacterium radiobacter biotype 2., J. Appl. Bacteriol., 34, 233, 10.1111/j.1365-2672.1971.tb02281.x New, 1972, Biological control of crown gall: Field observations and glasshouse experiments., J. Appl. Bacteriol., 35, 279, 10.1111/j.1365-2672.1972.tb03699.x Nuti, 1977, Large plasmids in different Rhizobium species., J. Gen. Microbiol., 100, 241, 10.1099/00221287-100-2-241 Nuti, 1980, Detection of Ti-plasmid sequences in infected tissues by in situ hybridization., Plant. Sci. Lett., 18, 1, 10.1016/0304-4211(80)90013-9 Ooms, G. (1981). “Molecular biologic studies on Agrobacterium tumefaciens and crown gall plant tumors.” Ph.D. thesis, Leiden University. Ooms, 1980, Characterization of Tn904 insertions in octopine Ti-plasmid mutants of Agrobacterium tumefaciens., J. Bacteriol., 144, 82, 10.1128/JB.144.1.82-91.1980 Ooms, 1981, Crown gall plant tumors of abnormal morphology, induced by Agrobacterium tumefaciens carrying mutated octopine Ti-plasmids; analysis of T-DNA functions., Gene, 14, 33, 10.1016/0378-1119(81)90146-3 Ooms, 1982, Octopine Ti-plasmid deletion mutants of Agrobacterium tumefaciens with emphasis on the right side of the T-region., Plasmid, 7, 15, 10.1016/0147-619X(82)90023-3 Ooms, 1982, T-DNA organization in homogeneous and heterogeneous octopine-type crown gall tissues of Nicotiana tabacum., Cell, 30, 589, 10.1016/0092-8674(82)90255-0 Ooms, 1982, Double infection of tobacco plants by two complementing octopine T-region mutants of Agrobacterium tumefaciens., Plant Mol. Biol., 1, 217, 10.1007/BF00021033 Otten, L. A. B. M. (1979). “Lysopine dehydrogenase and nopaline dehydrogenase from crown gall tumor tissues.” Ph.D. thesis, Leiden University. Otten, 1982, Lysopine dehydrogenase activity as an early marker in crown gall transformation., Plant Sci. Lett., 25, 15, 10.1016/0304-4211(82)90202-4 Otten, 1977, Properties of D(+) lysopine dehydrogenase from crown gall tumour tissue., Biochim. Biophys. Acta, 485, 268, 10.1016/0005-2744(77)90163-2 Otten, 1981, Mendelian transmission of genes introduced into plants by the Ti-plasmids of Agrobacterium tumefaciens., Mol. Gen. Genet., 183, 209, 10.1007/BF00270619 Owens, 1982, Characteristics of teratomas regenerated in vitro from octopine-type crown gall., Plant Physiol., 69, 37, 10.1104/pp.69.1.37 Panagopoulos, 1973, Characteristics of Greek isolates of Agrobacterium tumefaciens (Smith and Townsend) Conn., J. Appl. Bacteriol., 36, 233, 10.1111/j.1365-2672.1973.tb04096.x Parker, 1957, Characteristics of four rhizobiophages active against Rhizobium meliloti., Can. J. Microbiol., 3, 651, 10.1139/m57-071 Perry, 1982, Characteristics of Ti-plasmids from broad host range and ecologically specific biotype 2 and 3 strains of Agrobacterium tumefaciens., J. Bacteriol., 151, 343, 10.1128/JB.151.1.343-350.1982 Petit, 1975, Etude du métabolisme des guanidines des tissues de crown-gall par la souche T37 d'Agrobacterium tumefaciens., C. R. Acad. Sci. Paris Ser. D, 281, 467 Petit, 1976, Etude du métabolisme de l'homooctopine et de l'un de ses analogues par l'Agrobacterium tumefaciens., C. R. Acad. Sci. Paris Ser. D, 282, 69 Petit, 1978, Isolation of Agrobacterium Ti-plasmid regulatory mutants., Mol. Gen. Genet., 167, 147, 10.1007/BF00266908 Petit, 1970, Recherches sur les guanidines des tissues de crown-gall. Mise en évidence d'une relation biochimique spécifique entre les souches d'Agrobacterium tumefaciens et les tumeurs qu'elles induisent., Physiol. Veget., 8, 205 Petit, 1978, Substrate induction of conjugative activity of Agrobacterium tumefaciens Ti-plasmids., Nature (London), 271, 570, 10.1038/271570a0 Plotkin, 1980, Agrobacterium radiobacter prosthetic valve endocarditis., Ann. Int. Med., 93, 839, 10.7326/0003-4819-93-6-839 Prakash, 1982, Relationship between nif plasmids of fast-growing Rhizobium species and Ti-plasmids of Agrobacterium tumefaciens., J. Bacteriol., 149, 1129, 10.1128/JB.149.3.1129-1134.1982 Prakash, 1981, Large plasmids of fast-growing rhizobia: Homology studies and location of structural nitrogen fixation (nif) genes., J. Bacteriol., 145, 1129, 10.1128/JB.145.3.1129-1136.1981 Rao, 1982, Agrobacterium adherence involves the pectic portion of the host cell wall and is sensitive to the degree of pectin methylation., Physiol. Plant., 56, 374, 10.1111/j.1399-3054.1982.tb00356.x Regier, 1982, Secretion of trans-zeatin by Agrobacterium tumefaciens: A function determined by the nopaline Ti-plasmid., Biochem. Biophys. Res. Commun., 104, 1560, 10.1016/0006-291X(82)91429-2 Riker, 1923, Some relations of the crown gall organism to its host tissue., J. Agric. Res., 25, 119 Riker, 1924, Relations of temperature and moisture to the development of crown gall., Phytopathology, 14, 30 Riker, 1930, Studies on infectious hairy root of nursery apple trees., J. Agric. Res., 41, 507 Riley, 1977, Comparison of thirty-seven strains of Vd-3 bacteria with Agrobacterium radiobacter: Morphological and physiological observations., J. Clin. Microbiol., 5, 172, 10.1128/jcm.5.2.172-177.1977 Risuleo, 1982, Regions of homology between tumorigenic plasmids from Agrobacterium rhizogenes and Agrobacterium tumefaciens., Plamid, 7, 45 Rosenberg, 1982, Megaplasmids in the plant-associated bacteria Rhizobium meliloti and Pseudomonas solanacearum., J. Bacteriol., 150, 402, 10.1128/JB.150.1.402-406.1982 Roslycky, 1962, Phages for Agrobacterium radiobacter with reference to host range., Can. J. Microbiol., 8, 71, 10.1139/m62-010 Sacristàn, 1977, Regeneration of plants from “habituated” and “Agrobacterium-transformed” single cell clones of tobacco., Mol. Gen. Genet., 152, 111, 10.1007/BF00268806 Saedi, 1979, Tumor induction by Agrobacterium tumefaciens prevented in Vigna sinensis seedlings systemically infected by ribonucleic acid viruses., Infect. Immun., 23, 298, 10.1128/IAI.23.2.298-304.1979 Schilperoort, R. A. (1969). “Investigations on plant tumors—Crown Gall. On the biochemistry of tumor induction by Agrobacterium tumefaciens.” Ph.D. thesis, Leiden University. Schröder, 1982, Hybridization selection and translation of T-DNA encoded mRNAs from octopine tumors., Mol. Gen. Genet., 185, 51, 10.1007/BF00333789 Schröder, 1981, The mRNA for lysopine dehydrogenase in plant tumor cells is complementary to a Tiplasmid fragment., FEBS Lett., 129, 166, 10.1016/0014-5793(81)80781-8 Schröder, 1981, Expression of plant tumor-specific proteins in minicells of Escherichia coli: A fusion protein of lysopine dehydrogenase with chloramphenicol acetyltransferase., Nucleic Acids Res., 9, 5187, 10.1093/nar/9.20.5187 Schroth, 1965, Isolation of Agrobacterium tumefaciens-A. radiobacter group from soil., Phytopathology, 55, 645 Schweitzer, 1980, Expression of Ti-plasmid DNA in E. coli: Comparison of homologous fragments cloned from Ti-plasmids of Agrobacterium strains C58 and Ach5., Plasmid, 4, 196, 10.1016/0147-619X(80)90009-8 Schwinghamer, 1980, A method for improved lysis of some Gram-negative bacteria., FEMS Microbiol. Lett., 7, 157, 10.1111/j.1574-6941.1980.tb01597.x Sciaky, 1978, Fingerprints of Agrobacterium Tiplasmids., Plasmid, 1, 238, 10.1016/0147-619X(78)90042-2 Scott, 1979, Opine content of unorganized and teratomatous tobacco crown gall tissues., Plant Sci. Lett., 16, 239, 10.1016/0304-4211(79)90034-8 Semancik, 1978, Accumulation of viroid RNA in tumor cells after double infection by Agrobacterium tumefaciens and citrus exocortis viroid., Phytopathology, 68, 1288, 10.1094/Phyto-68-1288 Sheikholeslam, 1979, Multiple-size plasmids in Agrobacterium radiobacter and A., Tumefaciens. Phytopathology, 69, 54, 10.1094/Phyto-69-54 Simpson, 1982, DNA from the A6S/2 crown gall tumor contains scrambled Ti-plasmid sequences near its junctions with plant DNA., Cell, 29, 1005, 10.1016/0092-8674(82)90464-0 Skinner, 1977, An evaluation of the nile blue test for differentiating Rhizobia from Agrobacteria., J. Appl. Bacteriol., 43, 91, 10.1111/j.1365-2672.1977.tb00726.x Skoog, 1957, Chemical regulation of growth and organ formation in plant tissues cultured in vitro., Symp. Soc. Exp. Biol., 11, 118 Slota, 1982, Genetic isolation and physical characterization of pAgK84, the plasmid responsible for agrocin 84 production., Plasmid, 8, 175, 10.1016/0147-619X(82)90055-5 Smith, 1907, A plant tumor of bacterial origin., Science, 25, 671, 10.1126/science.25.643.671 Spano, 1982, Regeneration of plants from callus cultures of roots induced by Agrobacterium rhizogenes on tobacco., Z. Pflanzenphysiol., 106, 87, 10.1016/S0044-328X(82)80058-5 Spano, 1981, Hairy root: In vitro growth properties of tissues induced by Agrobacterium rhizogenes on tobacco., Plant Sci. Lett., 23, 299, 10.1016/0304-4211(81)90040-7 Spano, 1982, Identification of T-DNA in the root-inducing plasmid of the agropine type Agrobacterium rhizogenes 1855., Plant Mol. Biol., 1, 291, 10.1007/BF00027560 Stapp, 1927, Der bakterielle Pflanzenkrebs und seine Beziehungen zum tierischen und menschlichen Krebs., Ber. Dtsch. Bot. Ges., 45, 480 Stapp, 1938, Der Pflanzenkrebs und sein Erreger Pseudomonas tumefaciens VI. Mitteilung. Asparagus sprengeri Rgl. und Phaseolus vulgaris L. als Wirtspflanzen., Zentralbl. Bakteriol., 99, 116 Starr, 1946, The nutrition of phytopathogenic bacteria II. The genus Agrobacterium., J. Bacteriol., 52, 187, 10.1128/JB.52.2.187-194.1946 Stonier, 1960, Agrobacterium tumefaciens Conn. II. Production of an antibiotic substance., J. Bacteriol., 79, 889, 10.1128/JB.79.6.889-898.1960 Süle, 1978, Biotypes of Agrobacterium tumefaciens in Hungary., J. Appl. Bacteriol., 44, 207, 10.1111/j.1365-2672.1978.tb00792.x Süle, 1980, Agrocin resistance in virulent derivatives of Agrobacterium tumefaciens harboring the pTi plasmid., Physiol. Plant Pathol., 17, 347, 10.1016/S0048-4059(80)80028-2 Sutton, 1978, Characterization of the enzyme responsible for nopaline and ornaline synthesis in sunflower crown gall tissues., Plant Physiol., 62, 363, 10.1104/pp.62.3.363 Tait, 1982, Genetic map of the crown gall suppressive incW plasmid pSa., Mol. Gen. Genet., 186, 10, 10.1007/BF00422905 Tamm, 1954, Experimentelle Untersuchungen über die Verbreitung des bakteriellen Pflanzenkrebses und das Auftreten von Sekundärtumoren., Arch. Mikrobiol., 20, 273, 10.1007/BF00409626 Tate, 1979, Adenine N6-substituent of agrocin 84 determines its bacteriocin-like specifity., Nature (London), 280, 697, 10.1038/280697a0 Telford, 1977, Novel screening procedure for recombinant plasmids., Science, 195, 391, 10.1126/science.318763 Tempé, 1982, Occurrence and biosynthesis of opines., 427 Tempé, 1982, Opine utilization by Agrobacterium., 451 Tempé, 1977, Thermosensitive step associated with transfer of the Ti plasmid during conjugation: Possible relation to transformation in crown gall., Proc. Natl. Acad. Sci. U.S.A., 74, 2848, 10.1073/pnas.74.7.2848 Tempé, 1980, Preparation and properties of new catabolic substrates for two types of oncogenic plasmids in Agrobacterium tumefaciens., C. R. Acad. Sci. Paris Ser. D, 290, 1173 Tepfer, 1983, The potential uses of Agrobacterium rhizogenes in the genetic engineering of higher plants: Nature got there first., 61, 153 Tepfer, 1981, Production d'agropine par des racines formées sous l'action d'Agrobacterium rhizogenes, souche A4., C. R. Acad. Sci., 292, 153 Thomas, 1981, Molecular genetics of broad host range plasmid RK2., Plasmid, 5, 10, 10.1016/0147-619X(81)90074-3 Thomas, 1982, Maintenance of broad host range plasmid RK2 replicons in Pseudomonas aeruginosa., Nature (London), 298, 674, 10.1038/298674a0 Thomashow, 1980, Integration and organization of Ti plasmid sequences in crown gall tumors., Cell, 19, 729, 10.1016/S0092-8674(80)80049-3 Thomashow, 1980, Recombination between higher plant DNA and the Ti plasmid of Agrobacterium tumefaciens., Proc. Natl. Acad. Sci. U.S.A., 77, 6448, 10.1073/pnas.77.11.6448 Thomashow, 1980, Host range of Agrobacterium tumefaciens is determined by the Ti plasmid., Nature (London), 283, 794, 10.1038/283794a0 Thomashow, 1981, The relationship between the limited and wide host range octopine-type Ti plasmids of Agrobacterium tumefaciens., J. Bacteriol., 146, 484, 10.1128/JB.146.2.484-493.1981 Turgeon, 1981, Structure of grafted crown-gall teratoma shoots of tobacco: Regulation of transformed cells., Planta, 153, 42, 10.1007/BF00385316 Turgeon, 1976, Studies on the recovery of crown gall tumor cells., Proc. Natl. Acad. Sci. U.S.A., 73, 3562, 10.1073/pnas.73.10.3562 Ursic, 1981, A new antibiotic with known resistance factors, G418, inhibits plant cells., Biochem. Biophys. Res. Commun., 101, 1031, 10.1016/0006-291X(81)91852-0 Van Brussel, 1982, Small Leguminosae as test plants for nodulation of Rhizobium leguminosarum and other rhizobia and agrobacteria harbouring a leguminosarum Sym-plasmid., Plant Sci. Lett., 27, 317, 10.1016/0304-4211(82)90134-1 Van Larebeke, 1974, Large plasmid in Agrobacterium tumefaciens essential for crown-gall inducing ability., Nature (London), 252, 169, 10.1038/252169a0 Van Larebeke, 1975, Acquisition of tumour-inducing ability by non-oncogenic agrobacteria as a result of plasmid transfer., Nature (London), 255, 742, 10.1038/255742a0 Van Larebeke, 1977, Transfer of Ti plasmids between Agrobacterium strains by mobilisation with the conjugative plasmid RP4., Mol. Gen. Genet., 152, 119, 10.1007/BF00268807 Van Slogteren, G. M. S. (1983). “The characterization of octopine crown gall tumor cells. A study on the expression of Agrobacterium tumefaciens-derived T-DNA genes.” Ph.D. thesis, Leiden University. Van Slogteren, 1982, The lysopinedehydrogenase gene used as a marker for the selection of octopine crown gall cells., Plant Mol. Biol., 1, 133, 10.1007/BF00024976 Van Vliet, 1978, Transfer of RP4::Mu plasmids to Agrobacterium tumefaciens., Plasmid, 1, 446, 10.1016/0147-619X(78)90003-3 Vervliet, 1975, Characterization of different plaque-forming and defective temperate phages in Agrobacterium strains., J. Gen. Virol., 26, 33, 10.1099/0022-1317-26-1-33 Watson, 1975, Plasmid required for virulence of Agrobacterium tumefaciens., J. Bacteriol., 123, 255, 10.1128/JB.123.1.255-264.1975 Whatley, 1976, Role for Agrobacterium cell envelope lipopolysaccharide in infection site attachment., Infect. Immun., 13, 1080, 10.1128/IAI.13.4.1080-1083.1976 Whatley, 1978, Plasmid and chromosomal determination of Agrobacterium adherence specificity., J. Gen. Microbiol., 107, 395, 10.1099/00221287-107-2-395 White, 1980, Hairy root: Plasmid encodes virulence traits in Agrobacterium rhizogenes., J. Bacteriol., 141, 1134, 10.1128/JB.141.3.1134-1141.1980 White, 1980, Relationship of plasmids responsible for hairy root and crown gall tumorigenicity., J. Bacteriol., 144, 710, 10.1128/JB.144.2.710-720.1980 White, 1982, Tumor induction by Agrobacterium rhizogenes involves the transfer of plasmid DNA to the plant genome., Proc. Natl. Acad. Sci. U.S.A., 79, 3193, 10.1073/pnas.79.10.3193 White, 1972, The taxonomy of the crown-gall organism Agrobacterium tumefaciens and its relationship to Rhizobia and other Agrobacteria., J. Gen. Microbiol., 72, 565, 10.1099/00221287-72-3-565 Willmitzer, 1980, DNA from Ti plasmid present in nucleus and absent from plastids of crown gall plant cells., Nature (London), 287, 359, 10.1038/287359a0 Willmitzer, 1981, Nuclear and polysomal transcripts of T-DNA in octopine crown gall suspension and callus cultures., Mol. Gen. Genet., 182, 255, 10.1007/BF00269667 Willmitzer, 1981, Transcription of T-DNA in octopine and nopaline crown gall tumours is inhibited by low concentrations of α-amanitin., Nucleic Acids Res., 9, 4801, 10.1093/nar/9.19.4801 Willmitzer, 1982, DNA from Agrobacterium rhizogenes is transferred to and expressed in axenic hairy root plant tissues., Mol. Gen. Genet., 186, 16, 10.1007/BF00422906 Willmitzer, 1982, The t1-DNA in octopine crown-gall tumors codes for seven well-defined polyadenylated transcripts., EMBO J., 1, 139, 10.1002/j.1460-2075.1982.tb01137.x Willmitzer, 1983, Size, location and polarity of T-DNA encoded transcripts in nopaline crown gall tumors; common transcripts in octopine and nopaline tumors., Cell, 32, 1045, 10.1016/0092-8674(83)90289-1 Windass, 1980, Improved conversion of methanol to single-cell protein by Methylophilus methylotrophus, Nature (London), 287, 396, 10.1038/287396a0 Wood, 1965, Studies on the net uptake of solutes by normal and crown gall tumor cells., Proc. Natl. Acad. Sci. U.S.A., 54, 1532, 10.1073/pnas.54.6.1532 Wood, 1978, Differential expression of oncogenicity and nopaline synthesis in intact leaves derived from crown gall teratomas of tobacco., Differentiation, 11, 175, 10.1111/j.1432-0436.1978.tb00981.x Wullems, 1981, Differential expression of crown gall tumor markers in transformants obtained after in vitro Agrobacterium tumefaciens-induced transformation of cell wall regenerating protoplasts derived from Nicotiana tabacum., Proc. Natl. Acad. Sci. U.S.A., 78, 4344, 10.1073/pnas.78.7.4344 Wullems, 1981, Retention of tumor markers in F1 progeny plants from in vitro induced octopine and nopaline tumor tissues., Cell, 24, 719, 10.1016/0092-8674(81)90098-2 Yadav, 1980, T-DNA of a crown gall teratoma is covalently joined to host plant DNA., Nature (London), 287, 458, 10.1038/287458a0 Yadav, 1982, Short direct repeats flank the T-DNA on a nopaline Ti plasmid., Proc. Natl. Acad. Sci. U.S.A., 79, 6322, 10.1073/pnas.79.20.6322 Yang, 1981, Revertant seedlings from crown gall tumors retain a portion of the bacterial Ti-plasmid DNA sequences., Proc. Natl. Acad. Sci. U.S.A., 78, 4151, 10.1073/pnas.78.7.4151 Yang, 1980, Extensive transcription of foreign DNA in a crown gall teratoma., Biochem. Biophys. Res. Commun., 92, 1273, 10.1016/0006-291X(80)90424-6 Yang, 1980, Foreign DNA sequences in crown gall teratomas and their fate during the loss of the tumorous traits., Mol. Gen. Genet., 177, 707, 10.1007/BF00272683 Young, 1978, Conjugal transfer of cloning vectors derived from ColE1., Gene, 4, 175, 10.1016/0378-1119(78)90029-X Zaenen, 1974, Supercoiled circular DNA in crown gall-inducing Agrobacterium strains., J. Mol. Biol., 86, 109, 10.1016/S0022-2836(74)80011-2 Zambryski, 1980, Tumor DNA structure in plant cells transformed by A., Tumefaciens. Science, 209, 1385, 10.1126/science.6251546 Zambryski, 1982, Tumor induction by Agrobacterium tumefaciens: Analysis of the boundaries of T-DNA., J. Mol. Appl. Genet., 1, 361 Zimmerer, 1966, Isolation and morphology of temperate Agrobacterium tumefaciens bacteriophage., J. Bacteriol., 92, 746, 10.1128/JB.92.3.746-750.1966