The Mitochondrial Potassium Cycle

IUBMB Life - Tập 52 Số 3-5 - Trang 153-158 - 2001
Keith Garlid1, Petr Pauček2
1Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health & Science University, Beaverton 97006-8921, USA. [email protected]
2Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health & Science University, Beaverton, Oregon 97006-8921 , USA

Tóm tắt

AbstractThe mitochondrial K + cycle consists of influx and efflux pathways for K + and anions. Net movement of K + salts across the inner membrane causes changes of matrix volume, so regulation of the cycle is vital for maintaining the structural integrity of the organelle. The mitochondrial K + cycle also appears to play important roles in cellular pathophysiology in vivo. Opening the mitochondrial ATP‐sensitive K + channel (mitoK ATP ) prior to ischemia protects the heart from ischemia‐reperfusion injury. MitoK ATP is an important player in the cell signaling pathways for ischemic protection and also for gene transcription, roles that appear to depend on the ability of mitoK ATP opening to trigger increased mitochondrial production of reactive oxygen species. MitoK ATP opening during both ischemia and reperfusion and during the high work state is found to preserve the structure of the intermembrane space and thereby maintains the normally low outer membrane permeability to adenine nucleotides. This review discusses the properties of the mitochondrial K + cycle that help to understand the basis of these effects.

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IUBMB Life

Tập 52 Số 3-5

153-158

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