The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis

American Association for the Advancement of Science (AAAS) - Tập 341 Số 6145 - Trang 569-573 - 2013
Patrick M. Smith1, Michael R. Howitt1, Nicolai Panikov1, Monia Michaud1, Carey Ann Gallini1, Mohammad Bohlooly‐Y2, Jonathan N. Glickman3,4, Wendy S. Garrett5,6,7,1
1Departments of Immunology and Infectious Diseases and Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, USA.
2AstraZeneca, RAD-Transgenic, Mölndal, Sweden.
3Department of Pathology, Harvard Medical School, Boston, MA, USA
4Miraca Life Sciences, Newton, MA, USA.
5Broad Institute of Harvard and MIT, Cambridge, MA, USA
6Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
7Department of Medicine, Harvard Medical School, Boston, MA USA

Tóm tắt

Protecting the Guts Regulatory T cells (T regs ) in the gut are important sentinels in maintaining the peace between our gut and its trillions of resident bacteria and have been shown to be regulated by specific strains of bacteria in mouse models. Smith et al. (p. 569 , published online 4 July; see the Perspective by Bollrath and Powrie ) asked whether metabolite(s) generated by resident bacterial species may regulate T regs in the gut. Indeed, short-chain fatty acids (SCFAs), bacterial fermentation products of dietary fibers produced by a range of bacteria, restored colonic T reg numbers in mice devoid of a gut microbiota and increased T reg numbers in colonized mice. The effects of SCFAs on T regs were mediated through GPCR43, a receptor for SCFAs, which is expressed on colonic T regs . Mice fed SCFAs were protected against experimentally induced colitis in a manner that was dependent on GPR43-expressing T regs .

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American Association for the Advancement of Science (AAAS)

Tập 341 Số 6145

569-573

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