Nền tảng MR-Base hỗ trợ suy diễn nguyên nhân một cách hệ thống trên toàn bộ biểu hiện ở người
Tóm tắt
Những kết quả từ các nghiên cứu liên kết toàn bộ genome (GWAS) có thể được sử dụng để suy diễn các mối quan hệ nguyên nhân giữa các kiểu hình, bằng cách sử dụng một chiến lược được gọi là ngẫu nhiên Mendel hai mẫu (2SMR) và vượt qua nhu cầu dữ liệu cấp cá nhân. Tuy nhiên, các phương pháp 2SMR đang phát triển nhanh chóng và kết quả GWAS thường không được quản lý đầy đủ, làm giảm hiệu quả triển khai của phương pháp này. Do đó, chúng tôi đã phát triển MR-Base (
Từ khóa
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