The MG‐QOL15 Japanese version: Validation and associations with clinical factors

Muscle and Nerve - Tập 46 Số 2 - Trang 166-173 - 2012
Masayuki Masuda1, Kimiaki Utsugisawa2, Shigeaki Suzuki3, Yuriko Nagane2, Chiaki Kabasawa4, Yasushi Suzuki5, Yuko Shimizu4, Hiroya Utsumi6, Kazuo Fujihara7, Shinichiro Uchiyama4, Norihiro Suzuki3
1Department of Neurology, Tokyo Medical University, Tokyo, Japan
2Hanamaki General Hospital
3Department of Neurology, Keio University School of Medicine, Tokyo, Japan
4National Hospital Organization, Japan
5Department of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan
6Tokyo Medical University
7Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan

Tóm tắt

AbstractIntroduction:Our study aim was to produce a Japanese translation of the 15‐item Myasthenia Gravis Quality‐of‐Life Scale (MG‐QOL15), assess its reliability and validity, and examine clinical factors affecting self‐perceived QOL in MG.Methods:We evaluated 327 consecutive patients with MG seen at six neurological centers. All patients completed the Japanese version of the MG‐QOL15 (MG‐QOL15‐J), the Beck Depression Inventory—second edition (BDI‐II), and a generic health‐related QOL questionnaire, the SF‐36. Disease severity was determined according to the Myasthenia Gravis Foundation of America (MGFA) quantitative MG score and the MG composite.Results:The MG‐QOL15‐J exhibited adequate internal reliability, test–retest repeatability, and concurrent validity with SF‐36, disease severity, and known‐patient groups categorized by MGFA post‐intervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI‐II as independent factors negatively affecting QOL.Conclusion:The MG‐QOL15‐J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG. Muscle Nerve 46: 166–173, 2012

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Muscle and Nerve

Tập 46 Số 2

166-173

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