The Lipase/Lipoxygenase Bienzyme System in AOT Reversed Micelles in Octane

Russian Journal of Bioorganic Chemistry - Tập 28 - Trang 44-49 - 2002
I. M. Pavlenko1, O. S. Kuptsova1, N. L. Klyachko1, A. V. Levashov1
1Chemical Faculty, Vorob'evy gory, Moscow State University, GSP-3 Moscow, Russia

Tóm tắt

In this work it is shown that the bienzyme lipase/lipoxygenase system can function in reversed micelles of bis(2-ethyl)hexyl sulfosuccinate (AOT) in octane. As a lipase substrate, a fish fat preparation (fat of sea mammals) with a high content of polyunsaturated fatty acids was used. It was demonstrated that the bienzyme reaction proceeded in a stationary mode and had a rate-limiting step catalyzed by lipase. Under optimal conditions, the efficacy of functioning of the bienzyme system was by an order of magnitude higher than that in water. The lipase/lipoxygenase bienzyme system can be used as a new method of spectrophotometrical determination of lipase activity.

Tài liệu tham khảo

Carriere, F., Bezzine, S., and Verger, R., J. Mol. Catal. B, 1997, vol. 3, pp. 55-56. Borgstrom, B. and Brockman, H.L., Lipases, Amsterdam: Elsevier, 1984. Jaeger, K.E., Ransas, S., Dijkstra, B.W., Colson, C., van Heuvel, M., and Misset, O., FEMS, Microbiol. Rev., 1994, vol. 15, pp. 29-63. Gilbert, E.J., Enzyme Microb. Technol., 1993, vol. 15, pp. 634-645. Wohlfahrt, S. and Jaeger, K.E., BioEngineering, 1993, vol. 9, pp. 39-46. Gutman, A.L. and Shapira, M., Adv. Biochem. Eng. Biotechnol., 1995, vol. 52, pp. 87-128. Chopineau, J., Kieboom, P.G., Klibanov, A.M., and Riva, S., J. Am. Chem. Soc., 1998, vol. 110, pp. 584-589. Wicke-Planquart, C., Canaan, S., Riviere, M., Dupuis,L., and Verger, R., Protein Eng., 1996, vol. 9, pp. 1225-1232. Carriere, F., Moreau, H., Raphel, V., Laugier, R., Benicourt, C., Junien, J.L., and Verger, R., Eur. J. Biochem., 1991, vol. 202, pp. 75-83. Suzuki, A., Mizumoto, A., Sarr, M.J., and Dimagno, E.P., Gastroenterology, 1997, vol. 112, pp. 2048-2055. Gudmundsson, B.O., Almarsson, O., and Haraldsson, G.G., Tetrahedron. Lett., 1993, vol. 34, pp. 5791-5794. Fujita, Y., Matsukura, M., Hata, K., Shimoto, H., Sharyo,M., Skaguchi, H., and Gibson, K., Tappi J., 1992, vol. 75, pp. 117-122. Vogel, W.C. and Zieve, L., Clin. Chem. (Washington, D.C.), 1963, vol. 9, pp. 168-172. Rona, P. and Michaelis, L., Biochemistry, 1911, vol. 31, pp. 345-351. Fletcher, P.D.I. and Robinson, B.H., J. Chem. Soc., Faraday Trans. 1, 1985, vol. 81, pp. 2667-2679. Dole, V.P., J. Clin. Invest., 1956, vol. 35, pp. 150-156. Dole, V.P. and Meinertz, H., J. Biol. Chem., 1960, vol.235, pp. 2595-2601. Han, D., Kwon, D.Y., and Rhee, J.S., Agric. Biol. Chem., 1987, vol. 51, pp. 615-618. Walde, P., J. Amer. Oil. Chem. Soc., 1990, vol. 67, pp.110-115. Mattson, F.H. and Volpenhein, R.A., J. Amer. Oil. Chem. Soc., 1966, vol. 43, pp. 286-291. Zandonella, G., Haalck, L., Spener, F., Paltauf, F., and Hermetter, A., J. Mol. Catal., B: Enzym., 1997, vol. 3, p. 127-130. Varfolomeev, S.D. and Gurevich, K.G., Biokinetika (Biokinetics), Moscow: Fair Press, 1999, pp. 280-289. Martinek, K., Levashov, A.V., Klyachko, N.L., Khmel'nitskii, Yu.L., and Berezin, I.V., Biol. Membr., 1985, vol. 2, pp. 669-696. Martinek, K., Levashov, A.V., Klyachko, N.L., Pantin, V.I., and Berezin, I.V., Biochim. Biophys. Acta, 1981, vol. 657, pp. 277-294. Schmid, R.D. and Verger, R., Angew. Chem. Int. Ed., 1998, vol. 37, pp. 1608-1633. Kurganov, B.I., Shkarina, T.N., Malalhova, E.A., Davydov, D.R., and Chebotareva, N.A., Biochimie, 1989, vol.71, pp. 573-578. Marx, J.L., Science, 1982, vol. 215, pp. 1380-1382. Lagaede, M., Gualde, N., and Rigaud, M., Biochemistry, 1989, vol. 257, pp. 313-320.