The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

American Association for the Advancement of Science (AAAS) - Tập 342 Số 6161 - Trang 971-976 - 2013
Sophie Viaud1,2, Fabiana Saccheri1, Grégoire Mignot3,4, Takahiro Yamazaki1, Romain Daillère1,2, Dalil Hannani1, David Enot5,6, Christina Pfirschke7, Camilla Engblom7, Mikaël J. Pittet7, Andreas Schlitzer8, Florent Ginhoux8, Lionel Apétoh3,4, Élisabeth Chachaty9, Paul‐Louis Woerther9, Gérard Eberl10, M Bérard11, Chantal Ecobichon12,13, Dominique Clermont14, Chantal Bizet14, Valérie Gaboriau‐Routhiau15,16, Nadine Cerf‐Bensussan15,16, Paule Opolon17,18, Nadia Yessaad19,20,21,22, Éric Vivier19,20,21,22, Bernhard Ryffel23, Charles O. Elson24, Joël Doré25,15, Guido Kroemer26,5,6,27,28, Patricia Lepage25,15, Ivo G. Boneca12,13, François Ghiringhelli29,3,4, Laurence Zitvogel30,1,2
1Institut National de la Santé et de la Recherche Médicale, U1015, Equipe labellisée Ligue Nationale Contre le Cancer, Institut Gustave Roussy, Villejuif, France.
2Université Paris-Sud, Kremlin Bicêtre, France.
3Institut National de la Santé et de la Recherche Médicale, Group Avenir, Dijon, France.
4Institut National de la Santé et de la Recherche Médicale, U866, Centre Georges François Leclerc, Dijon, France.
5Institut National de la Santé et de la Recherche Médicale, U848, Institut Gustave Roussy, Villejuif, France.
6Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France
7Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
8Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), Singapore
9Service de Microbiologie, Institut Gustave Roussy, Villejuif, France.
10Lymphoid Tissue Development Unit, Institut Pasteur, Paris, France.
11Nimalerie Centrale, Institut Pasteur, Paris, France.
12Institut National de la Santé et de la Recherche Médicale, Group Avenir, Paris, France.
13Institut Pasteur, Unit Biology and Genetics of the Bacterial Cell Wall, Paris, France.
14Institut Pasteur, Collection de l’Institut Pasteur, Paris, France.
15Institut National de la Recherche Agronomique, Micalis–UMR1319, 78350 Jouy-en-Josas, France.
16Institut National de la Santé et de la Recherche Médicale U989, Université Paris Descartes, 75730 Paris, France.
17Institut Gustave Roussy, IFR54, Villejuif, France.
18Institut Gustave Roussy, Institut de Recherche en Cancérologie Intégrée de Villejuif (IRCIV), Laboratoire de Pathologie Expérimentale, Villejuif, France.
19Assistance Publique des Hôpitaux de Marseille, Hôpital de la Conception, Marseille, France.
20Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7280, Marseille, France
21Centre d’Immunologie de Marseille-Luminy, Aix-Marseille Université UM2, Marseille, France.
22Institut National de la Santé et de la Recherche Médicale, UMR 1104, Marseille, France.
23Laboratory of Molecular and Experimental Immunology and Neurogenetics, UMR 7355, CNRS-University of Orleans, Orleans, France.
24University of Alabama at Birmingham, Birmingham, AL, USA;
25AgroParisTech, Micalis–UMR1319, 78352 Jouy-en-Josas, France.
26Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France
27Pôle de Biologie, Hôpital Européen Georges Pompidou, Assistance Publique–Hôpitaux de Paris, Paris, France.
28Université Paris Descartes, Paris, France
29Faculté de Médecine, Université de Bourgogne, Dijon, France
30Centre d’Investigation Clinique Biothérapie CICBT 507, Institut Gustave Roussy, Villejuif, France.

Tóm tắt

The Microbiota Makes for Good Therapy The gut microbiota has been implicated in the development of some cancers, such as colorectal cancer, but—given the important role our intestinal habitants play in metabolism—they may also modulate the efficacy of certain cancer therapeutics. Iida et al. (p. 967 ) evaluated the impact of the microbiota on the efficacy of an immunotherapy [CpG (the cytosine, guanosine, phosphodiester link) oligonucleotides] and oxaliplatin, a platinum compound used as a chemotherapeutic. Both therapies were reduced in efficacy in tumor-bearing mice that lacked microbiota, with the microbiota important for activating the innate immune response against the tumors. Viaud et al. (p. 971 ) found a similar effect of the microbiota on tumor-bearing mice treated with cyclophosphamide, but in this case it appeared that the microbiota promoted an adaptive immune response against the tumors.

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American Association for the Advancement of Science (AAAS)

Tập 342 Số 6161

971-976

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