The INECO Frontal Screening for the Evaluation of Executive Dysfunction in Cerebral Small Vessel Disease: Evidence from Quantitative MRI in a CADASIL Cohort from Colombia

Journal of the International Neuropsychological Society - Tập 26 Số 10 - Trang 1006-1018 - 2020
Dorothée Schoemaker1,2, Yesica Zuluaga3, Anand Viswanathan4, Markus Shrimer5, Heirangi Torrico‐Teave2, Lina Velilla3, Carolina Ospina3, Gloria Garcia Ospina3, Francisco Lopera3, Joseph F. Arboleda‐Velásquez1, Yakeel T. Quiroz4,2,3
1Department of Ophthalmology, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
2Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 USA
3Grupo de Neurociencias, Universidad de Antioquia, Medellín 1226, Colombia
4Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
5Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich 81377, Germany

Tóm tắt

AbstractObjectives:Executive dysfunction is a predominant cognitive symptom in cerebral small vessel disease (SVD). The Institute of Cognitive Neurology Frontal Screening (IFS) is a well-validated screening tool allowing the rapid assessment of multiple components of executive function in Spanish-speaking individuals. In this study, we examined performance on the IFS in subjects with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), an inherited condition leading to the early onset of SVD. We further explored associations between performance on the IFS and magnetic resonance imaging (MRI) markers of SVD.Methods:We recruited 24 asymptomatic CADASIL subjects and 23 noncarriers from Colombia. All subjects underwent a research MRI and a neuropsychological evaluation, including the IFS. Structural MRI markers of SVD were quantified in each subject, together with an SVD Sum Score representing the overall burden of cerebrovascular alterations. General linear model, correlation, and receiver operating characteristic curve analyses were used to explore group differences on the IFS and relationships with MRI markers of SVD.Results:CADASIL subjects had a significantly reduced performance on the IFS Total Score. Performance on the IFS correlated with all quantified markers of SVD, except for brain atrophy and perivascular spaces enlargement. Finally, while the IFS Total Score was not able to accurately discriminate between carriers and noncarriers, it showed adequate sensitivity and specificity in detecting the presence of multiple MRI markers of SVD.Conclusions:These results suggest that the IFS may be a useful screening tool to assess executive function and disease severity in the context of SVD.

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Journal of the International Neuropsychological Society

Tập 26 Số 10

1006-1018

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