The Finnish Diabetes Prevention Study (DPS)

Diabetes Care - Tập 26 Số 12 - Trang 3230-3236 - 2003
Jaana Lindström1, Anne Louheranta2, Marjo Mannelin3, Merja Rastas4, Virpi Salminen5, Johan G. Eriksson1, Matti Uusitupa2, Jaakko Tuomilehto6,1
1Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
2Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
3Department of Sport Medicine, Oulu Deaconess Institute, Oulu, Finland
4Research and Development Centre, Social Insurance Institution, Turku, Finland
5Institute of Nursing and Health Care, Tampere, Finland
6Department of Public Health, University of Helsinki, Helsinki, Finland

Tóm tắt

OBJECTIVE—To describe the 1) lifestyle intervention used in the Finnish Diabetes Prevention Study, 2) short- and long-term changes in diet and exercise behavior, and 3) effect of the intervention on glucose and lipid metabolism.

RESEARCH DESIGN AND METHODS—There were 522 middle-aged, overweight subjects with impaired glucose tolerance who were randomized to either a usual care control group or an intensive lifestyle intervention group. The control group received general dietary and exercise advice at baseline and had an annual physician’s examination. The subjects in the intervention group received additional individualized dietary counseling from a nutritionist. They were also offered circuit-type resistance training sessions and advised to increase overall physical activity. The intervention was the most intensive during the first year, followed by a maintenance period. The intervention goals were to reduce body weight, reduce dietary and saturated fat, and increase physical activity and dietary fiber.

RESULTS—The intervention group showed significantly greater improvement in each intervention goal. After 1 and 3 years, weight reductions were 4.5 and 3.5 kg in the intervention group and 1.0 and 0.9 kg in the control group, respectively. Measures of glycemia and lipemia improved more in the intervention group.

CONCLUSIONS—The intensive lifestyle intervention produced long-term beneficial changes in diet, physical activity, and clinical and biochemical parameters and reduced diabetes risk. This type of intervention is a feasible option to prevent type 2 diabetes and should be implemented in the primary health care system.

Từ khóa


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