The Effects of Milk Supplementation on Bone Health Indices in Adults: A Meta-Analysis of Randomized Controlled Trials

Rizzoli, 2014, Dairy products, yogurts, and bone health, Am J Clin Nutr, 99, 1256S, 10.3945/ajcn.113.073056 Hidayat, 2020, Systematic review and meta-analysis of the association between dairy consumption and the risk of hip fracture: critical interpretation of the currently available evidence, Osteoporos Int, 31, 1411, 10.1007/s00198-020-05383-3 Michaëlsson, 2014, Milk intake and risk of mortality and fractures in women and men: cohort studies, BMJ, 349 Prince, 1995, The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women, J Bone Miner Res, 10, 1068, 10.1002/jbmr.5650100711 Storm, 1998, Calcium supplementation prevents seasonal bone loss and changes in biochemical markers of bone turnover in elderly New England women: a randomized placebo-controlled trial, J Clin Endocrinol Metab, 83, 3817 Heaney, 1999, Dietary changes favorably affect bone remodeling in older adults, J Am Diet Assoc, 99, 1228, 10.1016/S0002-8223(99)00302-8 Green, 2002, Impact of supplementary high calcium milk with additional magnesium on parathyroid hormone and biochemical markers of bone turnover in postmenopausal women, Asia Pac J Clin Nutr, 11, 268, 10.1046/j.1440-6047.2002.00300.x Lau, 2002, Milk supplementation prevents bone loss in postmenopausal Chinese women over 3 years, Bone, 31, 536, 10.1016/S8756-3282(02)00853-0 Chee, 2003, The effect of milk supplementation on bone mineral density in postmenopausal Chinese women in Malaysia, Osteoporos Int, 14, 828, 10.1007/s00198-003-1448-6 Daly, 2006, Calcium- and vitamin D3-fortified milk reduces bone loss at clinically relevant skeletal sites in older men: a 2-year randomized controlled trial, J Bone Miner Res, 21, 397, 10.1359/JBMR.051206 Kruger, 2006, Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women, Nutrition, 22, 1120, 10.1016/j.nut.2006.08.008 Woo, 2007, Milk supplementation and bone health in young adult Chinese women, J Women's Health, 16, 692, 10.1089/jwh.2006.0222 Bonjour, 2008, Inhibition of bone turnover by milk intake in postmenopausal women, Br J Nutr, 100, 866, 10.1017/S0007114508937429 Josse, 2010, Body composition and strength changes in women with milk and resistance exercise, Med Sci Sports Exercise, 42, 1122, 10.1249/MSS.0b013e3181c854f6 Kruger, 2010, The effect of a fortified milk drink on vitamin D status and bone turnover in post-menopausal women from South East Asia, Bone, 46, 759, 10.1016/j.bone.2009.10.036 Kukuljan, 2011, Independent and combined effects of calcium-vitamin D3 and exercise on bone structure and strength in older men: an 18-month factorial design randomized controlled trial, J Clin Endocrinol Metab, 96, 955, 10.1210/jc.2010-2284 Liu, 2011, Effect of milk and calcium supplementation on bone density and bone turnover in pregnant Chinese women: a randomized controlled trail, Arch Gynecol Obstet, 283, 205, 10.1007/s00404-009-1345-0 Gui, 2012, Bone mineral density in postmenopausal Chinese women treated with calcium fortification in soymilk and cow's milk, Osteoporos Int, 23, 1563, 10.1007/s00198-012-1895-z Kruger, 2012, High-calcium, vitamin D fortified milk is effective in improving bone turnover markers and vitamin D status in healthy postmenopausal Chinese women, Eur J Clin Nutr, 66, 856, 10.1038/ejcn.2012.54 Toxqui, 2014, Low iron status as a factor of increased bone resorption and effects of an iron and vitamin D-fortified skimmed milk on bone remodelling in young Spanish women, Eur J Nutr, 53, 441, 10.1007/s00394-013-0544-4 Groenendijk, 2020, A combined nutrition and exercise intervention influences serum vitamin B-12 and 25-hydroxyvitamin D and bone turnover of healthy Chinese middle-aged and older adults, J Nutr, 150, 2112, 10.1093/jn/nxaa149 Liu, 2020, Effect of whole soy and isoflavones daidzein on bone turnover and inflammatory markers: a 6-month double-blind, randomized controlled trial in Chinese postmenopausal women who are equol producers, Ther Adv Endocrinol Metab, 11, 10.1177/2042018820920555 Huschtscha, 2021, The effects of a high-protein dairy milk beverage with or without progressive resistance training on fat-free mass, skeletal muscle strength and power, and functional performance in healthy active older adults: a 12-week randomized controlled trial, Front Nutr, 8, 10.3389/fnut.2021.644865 Moher, 2009, Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement, PLoS Med, 6, 10.1371/journal.pmed.1000097 Higgins, 2020 Schwingshackl, 2016, Perspective: nutrigrade: a scoring system to assess and judge the meta-evidence of randomized controlled trials and cohort studies in nutrition research, Adv Nutr, 7, 994, 10.3945/an.116.013052 DerSimonian, 1986, Meta-analysis in clinical trials, Control Clin Trials, 7, 177, 10.1016/0197-2456(86)90046-2 Wilson Genant, 1994, Universal standardization for dual X-ray absorptiometry: patient and phantom cross-calibration results, J Bone Miner Res, 9, 1503, 10.1002/jbmr.5650091002 Lu, 2001, Standardization of bone mineral density at femoral neck, trochanter and Ward's triangle, Osteoporos Int, 12, 438, 10.1007/s001980170087 Higgins, 2003, Measuring inconsistency in meta-analyses, BMJ, 327, 557, 10.1136/bmj.327.7414.557 Egger, 1997, Bias in meta-analysis detected by a simple, graphical test, BMJ, 315, 629, 10.1136/bmj.315.7109.629 Duval, 2000, Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis, Biometrics, 56, 455, 10.1111/j.0006-341X.2000.00455.x Shi, 2020, Effects of dairy products on bone mineral density in healthy postmenopausal women: a systematic review and meta-analysis of randomized controlled trials, Arch Osteoporos, 15, 48, 10.1007/s11657-020-0694-y Tai, 2015, Calcium intake and bone mineral density: systematic review and meta-analysis, BMJ, 351 Cormick, 2021, Effect of calcium fortified foods on health outcomes: a systematic review and meta-analysis, Nutrients, 13, 316, 10.3390/nu13020316 Moslehi, 2015, Determinants of parathyroid hormone response to vitamin D supplementation: a systematic review and meta-analysis of randomised controlled trials, Br J Nutr, 114, 1360, 10.1017/S0007114515003189 Lotito, 2017, Serum parathyroid hormone responses to vitamin D supplementation in overweight/obese adults: a systematic review and meta-analysis of randomized clinical trials, Nutrients, 9, 241, 10.3390/nu9030241 Heaney, 2000, Calcium, dairy products and osteoporosis, J Am Coll Nutr, 19, 83S, 10.1080/07315724.2000.10718088 Heaney, 2007, Bone health, Am J Clin Nutr, 85, 300S, 10.1093/ajcn/85.1.300S Kerstetter, 2003, Dietary protein, calcium metabolism, and skeletal homeostasis revisited, Am J Clin Nutr, 78, 584S, 10.1093/ajcn/78.3.584S Cao, 2011, A diet high in meat protein and potential renal acid load increases fractional calcium absorption and urinary calcium excretion without affecting markers of bone resorption or formation in postmenopausal women, J Nutr, 141, 391, 10.3945/jn.110.129361 Feng, 2011, Disorders of bone remodeling, Ann Rev Pathol Mech Dis, 6, 121, 10.1146/annurev-pathol-011110-130203 Eastell, 2017, Use of bone turnover markers in postmenopausal osteoporosis, Lancet Diabetes Endocrinol, 5, 908, 10.1016/S2213-8587(17)30184-5 Recker, 2004, Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients, J Bone Miner Res, 19, 1628, 10.1359/JBMR.040710 Seeman, 2006, Bone quality – the material and structural basis of bone strength and fragility, N Engl J Med, 354, 2250, 10.1056/NEJMra053077 Szulc, 2009, Thinking inside and outside the envelopes of bone: dedicated to PDD, Osteoporos Int, 20, 1281, 10.1007/s00198-009-0994-y Bihuniak, 2015, The effects of dietary protein and amino acids on skeletal metabolism, Mol Cell Endocrinol, 410, 78, 10.1016/j.mce.2015.03.024 Hunt, 2009, Dietary protein and calcium interact to influence calcium retention: a controlled feeding study, Am J Clin Nutr, 89, 1357, 10.3945/ajcn.2008.27238 Dawson-Hughes, 2004, Effect of dietary protein supplements on calcium excretion in healthy older men and women, J Clin Endocrinol Metab, 89, 1169, 10.1210/jc.2003-031466 Schürch, 1998, Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial, Ann Intern Med, 128, 801, 10.7326/0003-4819-128-10-199805150-00002 Giustina, 2008, Growth hormone, insulin-like growth factors, and the skeleton, Endocr Rev, 29, 535, 10.1210/er.2007-0036 Garnero, 2000, Low serum IGF-1 and occurrence of osteoporotic fractures in postmenopausal women, Lancet North Am Ed, 355, 898, 10.1016/S0140-6736(99)05463-X Ohlsson, 2011, Older men with low serum IGF-1 have an increased risk of incident fractures: the MrOS Sweden study, J Bone Miner Res, 26, 865, 10.1002/jbmr.281 Bayless, 2017, Lactase non-persistence and lactose intolerance, Curr Gastroenterol Rep, 19, 23, 10.1007/s11894-017-0558-9 Obermayer-Pietsch, 2007, Adult-type hypolactasia and calcium availability: decreased calcium intake or impaired calcium absorption?, Osteoporos Int, 18, 445, 10.1007/s00198-006-0251-6 Huncharek, 2008, Impact of dairy products and dietary calcium on bone-mineral content in children: results of a meta-analysis, Bone, 43, 312, 10.1016/j.bone.2008.02.022 Sahni, 2017, Dairy intake is protective against bone loss in older vitamin D supplement users: the Framingham study, J Nutr, 147, 645, 10.3945/jn.116.240390 Mangano, 2019, Higher dairy intakes are associated with higher bone mineral density among adults with sufficient vitamin D status: results from the Boston Puerto Rican osteoporosis study, J Nutr, 149, 139, 10.1093/jn/nxy234 Lau, 2004, Benefits of milk powder supplementation on bone accretion in Chinese children, Osteoporos Int, 15, 654, 10.1007/s00198-004-1593-6 Dawson-Hughes, 2000, Effect of withdrawal of calcium and vitamin D supplements on bone mass in elderly men and women, Am J Clin Nutr, 72, 745, 10.1093/ajcn/72.3.745 Merrilees, 2000, Effects of diary food supplements on bone mineral density in teenage girls, Eur J Nutr, 39, 256, 10.1007/s003940070004 Lee, 1996, A follow-up study on the effects of calcium-supplement withdrawal and puberty on bone acquisition of children, Am J Clin Nutr, 64, 71, 10.1093/ajcn/64.1.71 Lee, 1997, Bone mineral acquisition in low calcium intake children following the withdrawal of calcium supplement, Acta Paediatr, 86, 570, 10.1111/j.1651-2227.1997.tb08936.x Slemenda, 1997, Reduced rates of skeletal remodeling are associated with increased bone mineral density during the development of peak skeletal mass, J Bone Miner Res, 12, 676, 10.1359/jbmr.1997.12.4.676 Daly, 2008, The skeletal benefits of calcium- and vitamin D3-fortified milk are sustained in older men after withdrawal of supplementation: an 18-mo follow-up study, Am J Clin Nutr, 87, 771, 10.1093/ajcn/87.3.771 Ting, 2007, A follow-up study on the effects of a milk supplement on bone mineral density of postmenopausal Chinese women in Malaysia, J Nutr Health Aging, 11, 69 Bonjour, 2001, Gain in bone mineral mass in prepubertal girls 3.5 years after discontinuation of calcium supplementation: a follow-up study, Lancet North Am Ed, 358, 1208, 10.1016/S0140-6736(01)06342-5 Sahni, 2010, Protective effect of high protein and calcium intake on the risk of hip fracture in the Framingham offspring cohort, J Bone Miner Res, 25, 2770, 10.1002/jbmr.194