The Effects of Direct-fed Microbial Supplementation, as an Alternative to Antibiotics, on Growth Performance, Intestinal Immune Status, and Epithelial Barrier Gene Expression in Broiler Chickens

Probiotics and Antimicrobial Proteins - Tập 9 Số 4 - Trang 397-405 - 2017
Ujvala Deepthi Gadde1, Seong-Hwan Oh1, Y. S. Lee1, Eric J. Davis2, Noah P. Zimmerman2, T. Rehberger2, Hyun S. Lillehoj1
1Animal Biosciences and Biotechnology Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, USDA, 10300 Baltimore Ave, Bldg. 1043, Beltsville, MD, 20705, USA
2Agro Biosciences Inc., 10437 Innovation Drive, Wauwatosa, WI, 53226, USA

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Tài liệu tham khảo

Al-Sadi R, Khatib K, Guo S, Ye D, Youssef M, Ma T (2011) Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier. Am J Physiol-Gastr L 300:G1054–G1064

Aliakbarpour HR, Chamani M, Rahimi G, Sadeghi AA, Qujeq D (2012) The Bacillus subtilis and lactic acid bacteria probiotics influences intestinal mucin gene expression, histomorphology and growth performance in broilers. Asian-Austral J Anim 25:1285–1293

Applegate TJ, Klose V, Steiner T, Ganner A, Schatzmayr G (2010) Probiotics and phytogenics for poultry: myth or reality? J Appl Poult Res 19:194–210

Bai K, Huang Q, Zhang J, He J, Zhang L, Wang T (2016) Supplemental effects of probiotic Bacillus subtilis fmbJ on growth performance, antioxidant capacity, and meat quality of broiler chickens. Poult Sci. doi: 10.3382/ps/pew246

Chen J, Tellez G, Richards JD, Escobar J (2015) Identification of potential biomarkers for gut barrier failure in broiler chickens. Front Vet Sci 2:14

Dersjant-Li Y, Awati A, Kromm C, Evans C (2014) A direct fed microbial containing a combination of three-strain Bacillus sp. can be used as an alternative to feed antibiotic growth promoters in broiler production. J Appl Anim Nutr 2:e11

FASS (2010) Guide for the care and use of agricultural animals in research and teaching, 3rd edn. Federation of Animal Science Societies, Champaign

Hong YH, Lillehoj HS, Lillehoj EP, Lee SH (2006) Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens. Vet Immunol Immunopathol 114:259–272

Jeong JS, Kim IH (2014) Effect of Bacillus subtilis C-3102 spores as a probiotic feed supplement on growth performance, noxious gas emission, and intestinal microflora in broilers. Poult Sci 93:3097–3103

Jiang Z, Applegate TJ, Lossie AC (2013) Cloning, annotation and developmental expression of the chicken intestinal MUC2 gene. PLoS One 8:e53781

Kim YS, Ho B (2010) Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep 12:319–330

La Ragione RM, Woodward MJ (2003) Competitive exclusion by Bacillus subtilis spores of Salmonella enterica serotype Enteritidis and Clostridium perfringens in young chickens. Vet Microbiol 94:245–256

Lee SH (2015) Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases. Intestinal Res 13:11–18

Lee KW, Lee SH, Lillehoj HS, Li GX, Jang SI, Babu US, Park MS, Kim DK, Lillehoj EP, Neumann AP, Rehberger TG, Siragusa GR (2010) Effects of direct-fed microbials on growth performance, gut morphometry, and immune characteristics in broiler chickens. Poult Sci 89:203–216

Lee KW, Lillehoj HS, Jang SI, Lee SH (2014) Effects of Salinomycin and Bacillus subtilis on growth performance and immune responses in broiler chickens. Res Vet Sci 97:305–309

Muller PY, Janovjak H, Miserez AR, Dobbie Z (2002) Processing of gene expression data generated by quantitative real-time RT-PCR. BioTechniques 32:1372–1374 1376, 1378–1379

Nguyen ATV, Nguyen DV, Tran MT, Nguyen LT, Nguyen AH, Phan TN (2015) Isolation and characterization of Bacillus subtilis CH16 strain from chicken gastrointestinal tracts for use as a feed supplement to promote weight gain in broilers. Lett Appl Microbiol 60:580–588

Park JH, Kim IH (2014) Supplemental effect of probiotic Bacillus subtilis B2A on productivity, organ weight, intestinal Salmonella microflora, and breast meat quality of growing broiler chicks. Poult Sci 93:2054–2059

SAS Institute Inc (2013) Base SAS® 9.4 procedures guide: statistical procedures, Second edn. SAS Institute Inc., Cary

Sen S, Ingale SL, Kim YW, Kim JS, Kim KH, Lohakare JD, Kim EK, Kim HS, Ryu MH, Kwon IK, Chae BJ (2012) Effect of supplementation of Bacillus subtilis LS 1-2 to broiler diets on growth performance, nutrient retention, caecal microbiology and small intestinal morphology. Res Vet Sci 93:264–268

Smirnov A, Perez R, Amit-Romach E, Sklan D, Uni Z (2005) Mucin dynamics and microbial populations in chicken small intestine are changed by dietary probiotic and antibiotic growth promoter supplementation. J Nutr 135:187–192

Song J, Xiao K, Ke YL, Jiao LF, Hu CH, Diao QY, Shi B, Zhou XT (2014) Effect of probiotic mixture on intestinal microflora, morphology, and barrier integrity of broilers subjected to heat stress. Poul Sci 93:581–588

Swaggerty CL, Kogut MH, Ferro PJ, Rothwell L, Pevzner IY, Kaiser P (2004) Differential cytokine mRNA expression in heterophils isolated from Salmonella-resistant and –susceptible chickens. Immunology 113:139–148

Teirlynck E, Guseem MDE, Dewulf J, Haesebrouck F, Ducatelle R, Van Immerseel F (2011) Morphometric evaluation of “dysbacteriosis” in broilers. Avian Pathol 40:139–144

Thomas CM, Versalovic J (2010) Probiotics-host communication: modulation of signaling pathways in the intestine. Gut Microbes 1:148–163

Tsirtsikos P, Fegeros K, Balaskas C, Kominakis A, Mountzouris KC (2012) Dietary probiotic inclusion level modulates intestinal mucin composition and mucosal morphology in broilers. Poult Sci 91:1860–1868

Ulluwishewa D, Anderson AC, McNabb WC, Moughan PJ, Well JM, Roy NC (2011) Regulation of tight junction permeability by intestinal bacteria and dietary components. J Nutr 141:769–776

Waititu SM, Yitbarek A, Matini E, Echeverry H, Kiarie E, Rodriguez-Lecompte JC, Nyachoti CM (2014) Effect of supplementing direct-fed microbials on broiler performance, nutrient digestibilities, and immune responses. Poult Sci 93:625–635

Weaver CT, Hatton RD, Mangan PR, Harrington LE (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 25:821–852

Wolfenden RE, Pumford NR, Morgan MJ, Shivaramaiah S, Wolfenden AD, Pixley CM, Green J, Tellez G, Hargis BM (2011) Evaluation of selected direct-fed microbial candidates on live performance and Salmonella reduction in commercial turkey brooding houses. Poult Sci 90:2627–2631

Yegani M, Korver DR (2008) Factors affecting intestinal health in poultry. Poult Sci 87:2052–2063

Zhang ZF, Zhou TX, Ao X, Kim IH (2012) Effects of β-glucan and Bacillus subtilis, on growth performance, blood profiles, relative organ weight and meat quality in broilers fed maize-soybean meal based diets. Livest Sci 150:419–424

Zhang ZF, Cho JH, Kim IH (2013) Effects of Bacillus subtilis UBT-MO2 on growth performance, relative immune organ weight, gas concentration in excreta, and intestinal microbial shedding in broiler chickens. Livest Sci 155:343–347