The Danish case‐control study of cutaneous malignant melanoma. I. Importance of host factors

International Journal of Cancer - Tập 42 Số 2 - Trang 200-206 - 1988
A Østerlind1, Margaret A. Tucker2, K Hou-Jensen3, B. J. Stone2, Gerda Engholm4, Ole Møller Jensen4
1Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark
2Enviromental Epidemiology Branch, Division of Cancer Etiology, National Cancer Institute, Bethesda, MD, USA
3Department of Pathology, Righospitalet, DK‐2100 Copenhagen Ø, Denmark
4Danish Cancer Society, Danish Cancer Registry, Institute of Cancer Epidemiology, Landskronagade 66, DK‐2100 Copenhagen Ø, Denmark

Tóm tắt

AbstractThe relationshop between cutaneous malignant melanoma and possible host factors was Investigated in a populationbased case‐control study from East Denmark over a 3‐year period. A total of 474 melanoma patlents and 926 population controls aged 20–79 years were interviewed. Patients with lentigo maligna melanoma were not included. The major constitutional risk factors were: number of raised naevi on the arms (RR = 5,1 for 5+ vs, none), degree of freckling (RR = 2.9 for many vs, none), and light hair colour (RR = 1.7 for blond/fair vs. dark brown/black), which were independent of one another. An apparent synergy between number of raised naevi on the arms and degree of freckling was found. Thus, persons at high risk of melanoma may be identified by a simple assessment of naevi and degree of freckling. No significent difference was found between superficial spreading melanoma and nodular melanoma with regard to the most important host factors.

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Tài liệu tham khảo

10.1038/bjc.1981.145

Anderson D. E., 1967, Hereditary aspects of malignant melignant melanoma, J. Amer. med. Ass., 200, 741, 10.1001/jama.1967.03120220043006

Beardmore G. L., 1972, Melanoma and skin cancer. Proc. International Cancer Conference, 39

10.1111/j.1365-2133.1983.tb07077.x

Breslow N. E., 1980, Statistical methods in cancer research

Clark W. H., 1969, Lentigo maligna and lentigo‐Maligna melanoma, Amer J. Path., 55, 39

Cole P., 1971, Attributable risk percent in case‐Control studies, Brit. J. prev. soc. Med., 25, 242

10.1002/ijc.2910390205

10.1002/1097-0142(19801015)46:8<1787::AID-CNCR2820460816>3.0.CO;2-S

10.1136/bmj.288.6411.99

10.1038/bjc.1986.10

Gart J. J., 1970, Point and interval estimation of the common odds ratio in the combination of 2 × 2 tables with fixed marginals, Biometrika, 57, 471

Gellin G. A., 1969, Malignant melanoma, A controlled study of possibly associated factors, Arch. Dermat., 99, 43, 10.1001/archderm.1969.01610190049008

10.1002/ijc.2910350303

10.1056/NEJM198501103120205

10.7326/0003-4819-102-4-458

Holman C. D. J., 1984, Pigmentary traits, ethnic origin, benign nevi, and family history as risk factors for cutaneous malignant melanoma, J. nat. Cancer Inst., 72, 257

Jensen O. M., 1980, Trends in malignant melanoma of the skin, Wld. Hlth. Stat. Q., 33, 2

10.1002/ijc.2910230407

Kope A. W., 1986, Familial malignant melanoma, J. Amer. med. Ass., 256, 1915, 10.1001/jama.1986.03380140085027

10.5694/j.1326-5377.1957.tb59648.x

10.1002/1097-0142(197311)32:5<1275::AID-CNCR2820320537>3.0.CO;2-8

10.2307/2282717

10.1111/j.1365-2559.1980.tb02918.x

Nordlund J. J., 1985, Demographic study of clinically atypical (dysplastic) nevi in patients with melanoma and comparison subjects, Cancer Res., 45, 1855

10.1007/978-3-642-82641-2_2

Pack G. T., 1963, The relaiton of race and complexion to the incidence of moles and melanomas, Ann. N. Y. Acad. Sci., 100, 719

Reynolds P., 1982, Familial and occupational risks associated with malignant melanoma of the skin, Amer. J. Epidemiol., 116, 570

10.1093/oxfordjournals.aje.a121626

Roush G. C., 1986, Dependence of total nevi on dysplastic nevi in determining risk for melanma, Prevent. Med., 15, 699

Scotto J., 1978, Skin cancer epidemiology: research needs, Nat. Cancer Inst. Monogr., 50, 169

10.1038/bjc.1985.255

10.1136/bmj.292.6535.1555

10.1002/sim.4780050108

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International Journal of Cancer

Tập 42 Số 2

200-206

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