The Danish case‐control study of cutaneous malignant melanoma. I. Importance of host factors
Tóm tắt
The relationshop between cutaneous malignant melanoma and possible host factors was Investigated in a populationbased case‐control study from East Denmark over a 3‐year period. A total of 474 melanoma patlents and 926 population controls aged 20–79 years were interviewed. Patients with lentigo maligna melanoma were not included. The major constitutional risk factors were: number of raised naevi on the arms (RR = 5,1 for 5+ vs, none), degree of freckling (RR = 2.9 for many vs, none), and light hair colour (RR = 1.7 for blond/fair vs. dark brown/black), which were independent of one another. An apparent synergy between number of raised naevi on the arms and degree of freckling was found. Thus, persons at high risk of melanoma may be identified by a simple assessment of naevi and degree of freckling. No significent difference was found between superficial spreading melanoma and nodular melanoma with regard to the most important host factors.
Từ khóa
Tài liệu tham khảo
Anderson D. E., 1967, Hereditary aspects of malignant melignant melanoma, J. Amer. med. Ass., 200, 741, 10.1001/jama.1967.03120220043006
Beardmore G. L., 1972, Melanoma and skin cancer. Proc. International Cancer Conference, 39
Breslow N. E., 1980, Statistical methods in cancer research
Clark W. H., 1969, Lentigo maligna and lentigo‐Maligna melanoma, Amer J. Path., 55, 39
Cole P., 1971, Attributable risk percent in case‐Control studies, Brit. J. prev. soc. Med., 25, 242
Gart J. J., 1970, Point and interval estimation of the common odds ratio in the combination of 2 × 2 tables with fixed marginals, Biometrika, 57, 471
Gellin G. A., 1969, Malignant melanoma, A controlled study of possibly associated factors, Arch. Dermat., 99, 43, 10.1001/archderm.1969.01610190049008
Holman C. D. J., 1984, Pigmentary traits, ethnic origin, benign nevi, and family history as risk factors for cutaneous malignant melanoma, J. nat. Cancer Inst., 72, 257
Jensen O. M., 1980, Trends in malignant melanoma of the skin, Wld. Hlth. Stat. Q., 33, 2
Kope A. W., 1986, Familial malignant melanoma, J. Amer. med. Ass., 256, 1915, 10.1001/jama.1986.03380140085027
Nordlund J. J., 1985, Demographic study of clinically atypical (dysplastic) nevi in patients with melanoma and comparison subjects, Cancer Res., 45, 1855
Pack G. T., 1963, The relaiton of race and complexion to the incidence of moles and melanomas, Ann. N. Y. Acad. Sci., 100, 719
Reynolds P., 1982, Familial and occupational risks associated with malignant melanoma of the skin, Amer. J. Epidemiol., 116, 570
Roush G. C., 1986, Dependence of total nevi on dysplastic nevi in determining risk for melanma, Prevent. Med., 15, 699
Scotto J., 1978, Skin cancer epidemiology: research needs, Nat. Cancer Inst. Monogr., 50, 169