The D2dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder

European Psychiatry - Tập 21 - Trang 180-185 - 2006
Bruce R. Lawford1,2, Ross Young2,3, Ernest P. Noble2,4, Burnett Kann5, Terry Ritchie2
1Greenslopes Private Hospital, Brisbane, QLD, Australia
2Alcohol Research Centre, Neuropsychiatric Institute, UCLA, Los Angeles, CA, USA
3School of Psychology and Counselling, Queensland University of Technology, Carseldine, Brisbane, Qld., Australia
4Brain Research Institute, UCLA, Los Angeles, CA, USA
5Nambour Hospital, Nambour, Qld., Australia

Tóm tắt

AbstractObjective.

To identify clusters of patients with post-traumatic stress disorder (PTSD) according to symptom profile and to examine the association of the A1 allele of the D2dopamine receptor (DRD2) gene with these clusters.

Method.

Fifty-seven untreated Caucasian Vietnam veterans with PTSD were administered the General Health Questionnaire-28 (GHQ) and the Mississippi Scale for combat-related PTSD. DRD2 allelic status was determined by PCR.

Results.

Subjects with the DRD2 Al allele compared to those without this allele had significantly higher scores on GHQ 2 (anxiety/insomnia), GHQ 3 (social dysfunction) and GHQ 4 (depression). Cluster analysis of the GHQ data identified two primary groups. A high psychopathology cluster (cluster 3), featured by high co-morbid levels of somatic concerns, anxiety/insomnia, social dysfunction and depression, and a low psychopathology cluster (cluster 1), manifested by the reverse pattern. Scores in each of the four GHQ groups were significantly higher in cluster 3 than cluster 1, as was Mississippi Scale PTSD score. DRD2 A1 allele veterans compared to those without this allele were significantly more likely to be found in the high than the low psychopathology cluster group.

Conclusions.

DRD2 variants are associated with severe co-morbid psychopathology in PTSD subjects.


Tài liệu tham khảo

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European Psychiatry

Tập 21

180-185

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