The Complete Genome Sequence of <i>Propionibacterium Acnes</i> , a Commensal of Human Skin

American Association for the Advancement of Science (AAAS) - Tập 305 Số 5684 - Trang 671-673 - 2004
Holger Brüggemann1,2, Anke Henne1,2, Frank Hirth1,2, Heiko Liesegang1,2, Arnim Wiezer1,2, Axel Strittmatter1,2, Sandra Hujer1,2, Peter Dürre1,2, Gerhard Gottschalk1,2
1Department of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany
2Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, Georg-August-University Göttingen, Grisebachstraße 8, 37077 Göttingen, Germany.

Tóm tắt

Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes –associated diseases.

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Tài liệu tham khảo

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This project was carried out within the framework of the Competence Network Göttingen “Genome Research on Bacteria” (GenoMik) financed by the German Federal Ministry of Education and Research (BMBF). A supporting grant was provided by the Niedersächisches Ministerium für Wissenschaft und Kultur to the Göttingen Genomics Laboratory. H.B. is holder of a fellowship of the German Academy of Natural Scientists Leopoldina funded by the BMBF.

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American Association for the Advancement of Science (AAAS)

Tập 305 Số 5684

671-673

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