The CD8+ dendritic cell subset

Immunological Reviews - Tập 234 Số 1 - Trang 18-31 - 2010
Ken Shortman1, William R. Heath2
1The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
2Department of Microbiology and Immunology, The University of Melbourne, Parkville, VIC, Australia

Tóm tắt

Summary:  Mouse lymphoid tissues contain a subset of dendritic cells (DCs) expressing CD8α together with a pattern of other surface molecules that distinguishes them from other DCs. These molecules include particular Toll‐like receptor and C‐type lectin pattern recognition receptors. A similar DC subset, although lacking CD8 expression, exists in humans. The mouse CD8+ DCs are non‐migrating resident DCs derived from a precursor, distinct from monocytes, that continuously seeds the lymphoid organs from bone marrow. They differ in several key functions from their CD8− DC neighbors. They efficiently cross‐present exogenous cell‐bound and soluble antigens on major histocompatibility complex class I. On activation, they are major producers of interleukin‐12 and stimulate inflammatory responses. In steady state, they have immune regulatory properties and help maintain tolerance to self‐tissues. During infection with intracellular pathogens, they become major presenters of pathogen antigens, promoting CD8+ T‐cell responses to the invading pathogens. Targeting vaccine antigens to the CD8+ DCs has proved an effective way to induce cytotoxic T lymphocytes and antibody responses.

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Tài liệu tham khảo

10.4049/jimmunol.159.2.565

10.4049/jimmunol.164.6.2978

10.4049/jimmunol.167.2.741

10.1016/0008-8749(89)90361-4

10.1084/jem.176.1.47

10.1093/intimm/9.7.1061

10.1084/jem.20021031

10.1002/jlb.67.2.206

Anjuère F, 1999, Definition of dendritic cell subpopulations present in the spleen, Peyer’s patches, lymph nodes, and skin of the mouse, Blood, 93, 590, 10.1182/blood.V93.2.590

10.1182/blood.V96.5.1865

10.1182/blood-2006-05-015354

10.4049/jimmunol.0802286

Leenen PJ, 1998, Heterogeneity of mouse spleen dendritic cells: in vivo phagocytic activity, expression of macrophage markers, and subpopulation turnover, J Immunol, 160, 2166, 10.4049/jimmunol.160.5.2166

10.4049/jimmunol.177.1.372

10.1182/blood-2008-05-155176

10.1172/JCI34584

10.1074/jbc.M709923200

10.1182/blood.V99.6.2084

10.4049/jimmunol.171.1.47

10.1186/gb-2008-9-1-r17

10.1182/blood-2003-02-0513

10.1084/jem.20071724

10.1084/jem.20071733

10.1084/jem.20071966

10.4049/jimmunol.0803364

10.1038/ni.1724

10.1002/eji.200323797

10.1084/jem.163.4.981

10.1038/nature07750

10.1084/jem.188.7.1359

10.1182/blood.V95.11.3489

10.1084/jem.184.5.1953

10.1182/blood.V99.6.2122

Brasel K, 2000, Generation of murine dendritic cells from flt‐3‐ligand‐supplemented bone marrow cultures, Blood, 96, 3029, 10.1182/blood.V96.9.3029

10.4049/jimmunol.174.11.6592

10.1038/ni1522

10.1182/blood-2002-04-1088

10.4049/jimmunol.170.3.1131

10.1084/jem.20021263

10.1182/blood-2007-07-100750

10.1126/science.1164206

10.4049/jimmunol.165.12.6762

10.1182/blood.V100.5.1734.h81702001734_1734_1741

10.1038/ni.1615

10.1016/j.immuni.2005.02.007

10.1038/ni1462

10.1182/blood.V99.3.999

10.1182/blood-2002-10-3186

10.1038/ni1340

10.4049/jimmunol.176.12.7196

10.1126/science.1170540

10.4049/jimmunol.170.7.3514

10.1073/pnas.0810268105

10.1038/362761a0

10.1084/jem.184.3.903

10.1084/jem.184.6.2185

10.4049/jimmunol.170.10.4926

10.1038/nature06840

10.1038/nature06839

10.1073/pnas.96.26.15068

10.1084/jem.191.7.1085

10.1126/science.290.5499.2152

10.1182/blood.V97.11.3333

10.1182/blood.V98.12.3376

10.1084/jem.20081385

10.1038/ni1518

10.4049/jimmunol.173.3.1826

10.1046/j.1365-2567.2002.01513.x

10.1084/jem.20020161

10.1073/pnas.0601956103

10.1084/jem.188.11.2163

10.1084/jem.192.12.1685

10.4049/jimmunol.166.9.5327

10.1073/pnas.0712394105

10.1126/science.1136080

10.4049/jimmunol.166.9.5448

10.1084/jem.186.11.1819

10.1084/jem.189.3.587

10.1073/pnas.96.3.1036

10.1016/S1074-7613(00)00045-5

10.1084/jem.192.6.823

10.4049/jimmunol.181.10.6923

10.1093/intimm/dxh210

10.1016/S0167-5699(98)01328-0

Kronin V, 1996, A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL‐2 production, J Immunol, 157, 3819, 10.4049/jimmunol.157.9.3819

10.1002/eji.1830271234

10.1093/intimm/13.4.465

10.1084/jem.183.4.1789

10.1093/intimm/dxh382

10.1002/eji.200526231

10.1046/j.1440-1711.2000.00902.x

10.1084/jem.184.3.923

10.1084/jem.188.2.415

10.1002/eji.1830261253

10.1016/1074-7613(95)90002-0

10.1002/eji.1830220421

Morgan DJ, 1999, Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens, J Immunol, 163, 723, 10.4049/jimmunol.163.2.723

10.1073/pnas.96.7.3854

10.4049/jimmunol.166.3.1439

10.1084/jem.20020827

10.1084/jem.20030315

10.1084/jem.20020861

10.1084/jem.20020991

10.1084/jem.20030966

10.1073/pnas.0402644101

10.1084/jem.194.6.769

10.1084/jem.20021598

10.1038/ni1265

10.1084/jem.171.2.377

10.1084/jem.188.2.409

10.4049/jimmunol.170.9.4437

10.1126/science.1087576

10.4049/jimmunol.172.4.1996

10.4049/jimmunol.175.1.196

10.1128/JVI.00452-09

10.1016/j.immuni.2006.03.014

10.1016/j.immuni.2006.04.017

10.1084/jem.20071365

10.1038/ni1505

10.4049/jimmunol.169.1.108

10.1126/science.1109893

10.1016/j.immuni.2006.07.015

10.1084/jem.20052450

10.1073/pnas.0806727105

10.1016/j.immuni.2006.07.017

10.4049/jimmunol.178.11.6861

10.1038/nature03326

10.4049/jimmunol.176.4.2161

10.1182/blood.V97.6.1733

10.1074/jbc.M502095200

10.1002/eji.200839035

10.1038/nri2173

10.1084/jem.20032220

10.1073/pnas.0610383104

10.4049/jimmunol.0900464

10.4049/jimmunol.177.4.2276

10.4049/jimmunol.168.12.6066

10.4049/jimmunol.171.10.5003

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Immunological Reviews

Tập 234 Số 1

18-31

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