The Association Between Frailty and All-Cause Mortality in Community-Dwelling Older Individuals: An Umbrella Review
Tóm tắt
Frailty is associated with multiple adverse health outcomes, including mortality. Several methods have been used to characterize frailty, each based on different frailty scales. These include scales based on phenotype, multidomain, and deficit accumulations. Several systematic reviews have examined the association between frailty and mortality; however, it is unclear whether these different frailty scales similarly predict mortality. This umbrella review aims to examine the association between frailty assessed by different frailty scales and all-cause mortality among community-dwelling older adults. A protocol was registered at PROSPERO, and it was conducted following the PRISMA statement. MEDLINE, Embase, PubMed, Cochrane Database of Systematic Reviews, Joanna Briggs Institute (JBI) EBP database, and Web of Science database was searched. Methodological quality was assessed using the JBI critical appraisal checklist and online AMSTAR-2 critical appraisal checklist. For eligible studies, essential information was extracted and synthesized qualitatively. Five systematic reviews were included, with a total of 434,115 participants. Three systematic reviews focused on single frailty scales; one evaluated Fried’s physical frailty phenotype and its modifications; another focused on the deficit accumulation frailty index. The third evaluated the FRAIL (Fatigue, Resistance, Ambulation, Illness, and Loss of weight) scale. The two other systematic reviews determined the association between frailty and mortality using different frailty scales. All of the systematic reviews found that frailty was significantly associated with all-cause mortality. This umbrella review demonstrates that frailty is a significant predictor of all-cause mortality, irrespective of the specific frailty scale.
Tài liệu tham khảo
Jang I-Y, Jung H-W, Lee HY, Park H, Lee E, Kim DH. Evaluation of Clinically Meaningful Changes in Measures of Frailty. J Gerontol A Biol Sci Med Sci. 2020;75(6):1143–7.
Walston J, Hadley EC, Ferrucci L, Guralnik JM, Newman AB, Studenski SA, et al. Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults. J Am Geriatr Soc. 2006;54(6):991–1001.
Ofori-Asenso R, Chin KL, Mazidi M, Zomer E, Ilomaki J, Zullo AR, et al. Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults: A Systematic Review and Meta-analysisGlobal Incidence of Frailty and Prefrailty Among Community-Dwelling Older AdultsGlobal Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults. JAMA Network Open. 2019;2(8):e198398-e.
Zhang Y, Yuan M, Gong M, Tse G, Li G, Liu T. Frailty and Clinical Outcomes in Heart Failure: A Systematic Review and Meta-analysis. J Am Med Dir Assoc. 2018;19(11):1003–8.e1.
Stewart R. Cardiovascular Disease and Frailty: What Are the Mechanistic Links? Clin Chem. 2019;65(1):80–6.
Evans NR, Wall J, To B, Wallis SJ, Romero-Ortuno R, Warburton EA. Clinical frailty independently predicts early mortality after ischaemic stroke. Age and ageing. 2020;49(4):588–91.
Taylor-Rowan M, Cuthbertson G, Keir R, Shaw R, Drozdowska B, Elliott E, et al. The prevalence of frailty among acute stroke patients, and evaluation of method of assessment. Clin Rehabil. 2019;33(10):1688–96.
Ethun CG, Bilen MA, Jani AB, Maithel SK, Ogan K, Master VA. Frailty and cancer: Implications for oncology surgery, medical oncology, and radiation oncology. CA Cancer J Clin. 2017;67(5):362–77.
Chen KW, Chang SF, Lin PL. Frailty as a Predictor of Future Fracture in Older Adults: A Systematic Review and Meta-Analysis. Worldviews Evid Based Nurs. 2017;14(4):282–93.
Maxwell CA, Patel MB, Suarez-Rodriguez LC, Miller RS. Frailty and Prognostication in Geriatric Surgery and Trauma. Clin Geriatr Med. 2019;35(1):13–26.
Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM, Bernabei R, et al. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14(6):392–7.
Veronese N. Frailty as Cardiovascular Risk Factor (and Vice Versa). Adv Exp Med Biol. 2020;1216:51–4.
Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.
Rockwood K, Mitnitski A, Song X, Steen B, Skoog I. Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70. J Am Geriatr Soc. 2006;54(6):975–9.
Xue QL. The frailty syndrome: definition and natural history. Clin Geriatr Med. 2011;27(1):1–15.
Vermeiren S, Vella-Azzopardi R, Beckwee D, Habbig AK, Scafoglieri A, Jansen B, et al. Frailty and the Prediction of Negative Health Outcomes: A Meta-Analysis. J Am Med Dir Assoc. 2016;17(12):1163.e1–.e17.
Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. Can Med Assoc J. 2005;173(5):489–95.
Mitnitski AB, Mogilner AJ, Rockwood K. Accumulation of deficits as a proxy measure of aging. Scientific World Journal. 2001;1:323–36.
Kim DH, Schneeweiss S, Glynn RJ, Lipsitz LA, Rockwood K, Avorn J. Measuring Frailty in Medicare Data: Development and Validation of a Claims-Based Frailty Index. J Gerontol A Biol Sci Med Sci. 2018;73(7):980–7.
Kim DH, Patorno E, Pawar A, Lee H, Schneeweiss S, Glynn RJ. Measuring Frailty in Administrative Claims Data: Comparative Performance of Four Claims-Based Frailty Measures in the U.S. Medicare Data. J Gerontol A Biol Sci Med Sci. 2020;75(6):1120–5.
Khadka J, Visvanathan R, Theou O, Moldovan M, Amare AT, Lang C, et al. Development and validation of a frailty index based on Australian Aged Care Assessment Program data. Med J Aust. 2020;213(7):321–6.
Romero-Ortuno R, Walsh CD, Lawlor BA, Kenny RA. A Frailty Instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE). BMC Geriatrics. 2010;10(1):57.
Clegg A, Bates C, Young J, Ryan R, Nichols L, Ann Teale E, et al. Development and validation of an electronic frailty index using routine primary care electronic health record data. Age and Ageing. 2016;45(3):353–60.
Lunenfeld B, Stratton P. The clinical consequences of an ageing world and preventive strategies. Best Pract Res Clin Obstet Gynaecol 2013;27(5):643–59.
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009;339:b2700.
Kojima G, Iliffe S, Walters K. Frailty index as a predictor of mortality: a systematic review and meta-analysis. Age Ageing. 2018;47(2):193–200.
Kojima G. Frailty Defined by FRAIL Scale as a Predictor of Mortality: A Systematic Review and Meta-analysis. J Am Med Dir Assoc. 2018;19(6):480–3.
Aromataris E, Fernandez R, Godfrey CM, Holly C, Khalil H, Tungpunkom P. Summarizing systematic reviews. Int J Evid Based Healthc. 2015;13(3):132–40.
Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017;358:j4008.
Houles M, Abellan Van Kan G, Rolland Y, Andrieu S, Anthony P, Bauer J, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people. [French]. Cahiers de l’Annee Gerontologique. 2010;2(1):13–23.
Abellan van Kan G, Rolland Y, Andrieu S, Bauer J, Beauchet O, Bonnefoy M, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging. 2009;13(10):881–9.
Chang SF, Lin PL. Systematic Literature Review and Meta-Analysis of the Association of Sarcopenia With Mortality. Worldviews Evid Based Nurs. 2016;13(2):153–62.
Kusumastuti S, Rozing MP, Lund R, Mortensen EL, Westendorp RGJ. The added value of health indicators to mortality predictions in old age: A systematic review. Eur J Intern Med. 2018;57:7–18.
Kane RL, Shamliyan T, Talley K, Pacala J. The association between geriatric syndromes and survival. J Am Geriatr Soc. 2012;60(5):896–904.
Poulton A, Shaw JF, Nguyen F, Wong C, Lampron J, Tran A, et al. The Association of Frailty With Adverse Outcomes After Multisystem Trauma: A Systematic Review and Meta-analysis. Anesth Analg. 2020;130(6):1482–92.
Xu BY, Yan S, Low LL, Vasanwala FF, Low SG. Predictors of poor functional outcomes and mortality in patients with hip fracture: a systematic review. BMC Musculoskelet Disord. 2019;20(1):568.
Cheng MH, Chang SF. Frailty as a Risk Factor for Falls Among Community Dwelling People: Evidence From a Meta-Analysis. J Nurs Scholarsh. 2017;49(5):529–36.
Zhang XE, Cheng B, Wang Q. Relationship between high blood pressure and cardiovascular outcomes in elderly frail patients: A systematic review and meta-analysis. Geriatr Nurs. 2016;37(5):385–92.
Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A Task Force on frailty assessment of older people in clinical practice. J Nutr Health Aging. 2008;12(1):29–37.
Zhang X, Dou Q, Zhang W, Wang C, Xie X, Yang Y, et al. Frailty as a Predictor of All-Cause Mortality Among Older Nursing Home Residents: A Systematic Review and Meta-analysis. J Am Med Dir Assoc. 2019;20(6):657–63.e4.
Pugh R, John DL, Thorpe C, Subbe C. Frailty measures in the critically ill: are we approaching a critical age? A systematic review. Critical Care. 2014;18(Suppl 1):P50–P.
Van der Elst M, Schoenmakers B, Duppen D, Lambotte D, Fret B, Vaes B, et al. Interventions for frail community-dwelling older adults have no significant effect on adverse outcomes: a systematic review and meta-analysis. BMC Geriatr. 2018;18(1):249.
Moraes MB, Araujo CFM, Avgerinou C, Vidal EIO. Nutritional interventions for the treatment of frailty in older adults: a systematic review protocol. Medicine (Baltimore). 2018;97(52):e13773.
Shears M, McGolrick D, Waters B, Jakab M, Boyd JG, Muscedere J. Frailty measurement and outcomes in interventional studies: protocol for a systematic review of randomised control trials. BMJ Open. 2017;7(12):e018872.
Apostolo J, Cooke R, Bobrowicz-Campos E, Santana S, Marcucci M, Cano A, et al. Predicting risk and outcomes for frail older adults: an umbrella review of frailty screening tools. JBI Database Of Systematic Reviews And Implementation Reports. 2017;15(4):1154–208.
Chang SF, Lin PL. Frail phenotype and mortality prediction: a systematic review and meta-analysis of prospective cohort studies. Int J Nurs Stud. 2015;52(8):1362–74.
Shamliyan T, Talley KM, Ramakrishnan R, Kane RL. Association of frailty with survival: a systematic literature review. Ageing Res Rev. 2013;12(2):719–36.
Rockwood K, Song X, Mitnitski A. Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey. Can Med Assoc J. 2011;183(8):E487–94.
Cawthon PM, Marshall LM, Michael Y, Dam TT, Ensrud KE, Barrett-Connor E, et al. Frailty in older men: prevalence, progression, and relationship with mortality. J Am Geriatr Soc. 2007;55(8):1216–23.
Ensrud KE, Ewing SK, Cawthon PM, Fink HA, Taylor BC, Cauley JA, et al. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc. 2009;57(3):492–8.
Gu D, Dupre ME, Sautter J, Zhu H, Liu Y, Yi Z. Frailty and Mortality Among Chinese at Advanced Ages. J Gerontol B Psychol Sci Soc Sci 2009;64B(2):279–89.
Puts MTE, Lips P, Deeg DJH. Sex Differences in the Risk of Frailty for Mortality Independent of Disability and Chronic Diseases. J Am Geriatr Soc. 2005;53(1):40–7.
Bandeen-Roche K, Xue Q-L, Ferrucci L, Walston J, Guralnik JM, Chaves P, et al. Phenotype of Frailty: Characterization in the Women’s Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2006;61(3):262–6.