Thụ Thể Andrgenic và VEGF: Cơ Chế Điều Hòa Angiogenesis Bởi Andrgen Trong Ung Thư Tuyến Tiền Liệt
Tóm tắt
Sự tiến triển của ung thư tuyến tiền liệt được kiểm soát bởi thụ thể androgen và sự hình thành mạch máu mới, hoặc angiogenesis, điều này thúc đẩy sự phát triển của ung thư tuyến tiền liệt di căn. Angiogenesis được kích thích bởi sự gia tăng biểu hiện của yếu tố tăng trưởng nội mô mạch máu (VEGF). VEGF bị điều hòa bởi nhiều yếu tố trong môi trường vi mô của khối u, bao gồm mức oxy thấp và nồng độ androgen cao. Ở đây, chúng tôi xem xét bằng chứng mô tả các cơ chế điều hòa VEGF qua hormone, bao gồm các tương tác mới giữa thụ thể androgen (AR), các yếu tố phiên mã epigenetic và zinc-finger, các biến thể AR và yếu tố thiếu oxy, HIF-1. Ý nghĩa của việc mô tả tác động của cả hormone và thiếu oxy lên biểu hiện VEGF và angiogenesis được tiết lộ trong các báo cáo gần đây về các liệu pháp lâm sàng nhắm mục tiêu vào cả con đường tín hiệu VEGF và AR. Việc hiểu rõ hơn về những phức tạp của biểu hiện VEGF có thể dẫn đến việc nhắm mục tiêu tốt hơn và kéo dài thời gian sống cho một nhóm bệnh nhân mắc ung thư tuyến tiền liệt kháng hormone di căn.
Từ khóa
#ung thư tuyến tiền liệt #thụ thể androgen #VEGF #angiogenesis #HIF-1 #yếu tố tăng trưởng nội mô mạch máuTài liệu tham khảo
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