The Age‐Well observational study on expert meditators in the Medit‐Ageing European project

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 4 - Trang 756-764 - 2018
Antoine Lutz1, Olga M. Klimecki2, Fabienne Collette3,4, Géraldine Poisnel5, Eider Arenaza-Urquijo5, Natalie L. Marchant6, Vincent De La Sayette7,8, Géraldine Rauchs7, Eric Salmon3,4, Patrick Vuilleumier9, Eric Frison10,11, Denis Vivien5,8, Gaël Chételat5
1Lyon Neuroscience Research Center INSERM U1028, CNRS UMR5292, Lyon University, Lyon, France
2Swiss Center for Affective Sciences, Department of Medicine and Department of Psychology, University of Geneva, Geneva, Switzerland
3GIGA-CRC In Vivo Imaging, Université de Liège, Liège, Belgium
4Belgian National Fund for Scientific Research (F.R.S.-FNRS), Bruxelles, Belgium
5Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1237, GIP Cyceron, Caen, France
6Division of Psychiatry, University College London, London, United Kingdom
7Université Normandie, Inserm, Université de Caen-Normandie, Inserm UMR-S U1077, GIP Cyceron, Caen, France
8CHU Caen-Normandie, Department of Clinical Research, Caen, France
9Department of Medicine, University of Geneva, Geneva, Switzerland
10EUCLID/F-CRIN Clinical Trials Platform, University of Bordeaux, INSERM, Bordeaux Population Health Center, Bordeaux, France
11CHU Bordeaux, F-33000, Bordeaux, France

Tóm tắt

AbstractIntroductionThe Age‐Well observational, cross‐sectional study investigates the affective and cognitive mechanisms of meditation expertise with behavioral, neuroimaging, sleep, and biological measures sensitive to aging and Alzheimer's disease (AD).MethodsThirty cognitively unimpaired individuals aged 65 years or older with at least 10,000 hours of practice in mindfulness meditation (MM) and loving‐kindness and compassion meditation (LKCM) are selected. The outcomes are the neuroimaging brain correlates of MM and LKCM and the assessments of long‐term meditation practices on behavioral, neural, and biological measures as compared to nonmeditator older controls from the Age‐Well randomized controlled trial.ResultsRecruitment and data collection began in late 2016 and will be completed by late 2019.DiscussionResults are expected to foster the understanding of the effects of meditation expertise on aging and of the mechanisms of action underlying the meditation intervention in the Age‐Well randomized controlled trial. These finding will contribute to the design of meditation‐based prevention randomized controlled trials for the aged population and to the exploration of the possible long‐time developmental trajectory of meditation training.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 4

756-764

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