The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease

Alzheimer's and Dementia: Translational Research and Clinical Interventions - Tập 2 - Trang 82-92 - 2016
José Luis Molinuevo1, Nina Gramunt1, Juan Domingo Gispert1, Karine Fauria1, Manel Esteller2,3,4, Carolina Minguillon1, Gonzalo Sánchez-Benavides1, Gema Huesa1, Sebastián Morán2,3, Rafael Dal-Ré1, Jordi Camí5,6
1Barcelonabeta Brain Research Center, Barcelona, Spain
2Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain
3Department of Physiological Sciences II, School of Medicine, University of Barcelona (UB), Barcelona, Spain
4Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
5Pasqual Maragall Foundation, Barcelona, Spain
6Universitat Pompeu Fabra, Barcelona, Spain

Tóm tắt

AbstractIntroductionThe preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project, including the ALFA registry and parent cohort and the nested ALFA+ cohort study.MethodsThe ALFA parent cohort baseline visit included full cognitive evaluation, lifestyle habits questionnaires, DNA extraction, and MRI. The nested ALFA+ study adds wet and imaging biomarkers for deeper phenotyping.ResultsA total of 2743 participants aged 45 to 74 years were included in the ALFA parent cohort. We show that this cohort, mostly composed of cognitively normal offspring of AD patients, is enriched for AD genetic risk factors.DiscussionThe ALFA project represents a valuable infrastructure that will leverage with different studies and trials to prevent AD. The longitudinal ALFA+ cohort will serve to untangle the natural history of the disease and to model the preclinical stages to develop successful trials.

Tài liệu tham khảo

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Alzheimer's and Dementia: Translational Research and Clinical Interventions

Tập 2

82-92

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