Temporal trends in the HIV‐1 epidemic in Russia: Predominance of subtype A

Journal of Medical Virology - Tập 74 Số 2 - Trang 191-196 - 2004
Aleksei F. Bobkov1, Kazennova Ev1, L. M. Selimova1, Tatyana A. Khanina1, Grigory S. Ryabov1, Bobkova Mr2, Anna L. Sukhanova2, А В Кравченко2, Ladnaia Nn2, Jonathan Weber3, Vadim Pokrovsky2
1The D.I. Ivanovsky Institute of Virology, Moscow, Russia
2Federal AIDS Centre, Moscow, Russia
3Wright-Fleming Institute, Imperial College, London, United Kingdom

Tóm tắt

AbstractDuring the period 1996–1997, three highly homogeneous variants of HIV‐1 were identified, circulating among injecting drug users (IDUs) in the former Soviet Union republics. One of these belonged to HIV‐1 genetic subtype A (IDU‐A), another belonged to HIV‐1 genetic subtype B (IDU‐B) and the third was a recombinant between the first two variants (CRF03_AB). However, since 1997, the HIV‐1 epidemic has affected an increasing number of geographic regions in Russia. This study was undertaken to survey the prevailing genetic variants and to estimate the current proportions of these three HIV‐1 genetic subtypes in Russia. Blood samples were taken in 1999–2003 from 1090 HIV‐infected individuals and analysed by gag/env HMA. The IDU‐A variant was found to be the majority variant (89.7–100%) in 44 of 45 regions of the Russian Federation studied. The IDU‐A variant was also found to spreading rapidly through heterosexual transmission in 1999–2003 (30/34, 88%). CRF03_AB predominates in the Kaliningrad region only (28/29, 96.6%). The IDU‐B variant is currently of minor importance in the IDU epidemic but other European subtype B variants predominate among men having sex with men (18/18, 100%). Sequence analysis of the env V3 encoding regions derived from HIV‐1 infected individuals in Yekaterinburg (the main centre of the HIV‐1 epidemic in Russia in 2002–2003) showed that the IDU‐A variant is still highly homogeneous. The mean pairwise nucleotide distance (n = 9) was 2.89 ± 1.14 (range 1.36–6.14). However, the mean genetic distance between each sequence within the samples collected from the Yekaterinburg IDU‐A variant subset and the IDU‐A consensus is 2.51 ± 1.06 (range 1.36–4.66) and considerably higher than in South Russia in 1996 (0.79 ± 0.51, range 0.38–1.90). The current HIV‐1 epidemic in Russia is almost entirely caused by a highly homogeneous A‐subtype strain, which will influence vaccine development strategies and must be taken into account in the quality control of molecular tests for the diagnosis of HIV‐1. J. Med. Virol. 74:191–196, 2004. © 2004 Wiley‐Liss, Inc.

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Tài liệu tham khảo

10.1089/aid.1996.12.1687

10.1089/aid.1997.13.725

10.1089/aid.1997.13.1195

10.1089/aid.1998.14.1597

10.1089/aid.1998.14.669

10.1089/088922201750063188

Bobkov AF, 2002, Molecular genetic characteristics of HIV‐1 in Russia, Vestn Akad Med Nauk SSSR, 8, 40

10.1126/science.8235655

Felsenstein J, 1989, PHYLIP—Phylogenetic interference package (version 3.2), Cladistics, 5, 164

10.1089/088922299310007

10.1128/JVI.74.1.363-370.2000

Kazennova EV, 2001, Analysis of gag gene subtypes of HIV‐1 variants isolated in Russia by comparative assessment of heteroduplex electrophoretic mobility, Vopr Virusol, 45, 12

10.1007/BF01731581

Leinikki P, 1996, Identification of genetic subtypes of HIV‐1 circulating on the territory of Russia, Zh Mikrobiol, 6, 25

10.1097/00002030-199814000-00023

10.1089/aid.1998.14.1299

10.1089/088922299309874

10.1089/08892220260190380

10.1089/aid.1998.14.1079

10.1089/088922201750461375

10.1089/088922201750056816

ZetterbergV UstinaV LiitsolaK KalikovaN ZilmerK Brummer‐KorvenkontioH LeinikkiP SalminenM.2002.CRF06‐cpx and subtype A (Eastern European strain) are responsible for the explosive injecting drug use‐associated HIV‐1 epidemic in Estonia. Abstracts of the XIV International AIDS Conference Barcelona Spain July 2–12. Abstract TuPeC4799.

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Journal of Medical Virology

Tập 74 Số 2

191-196

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