Teeth Loss and Risk of Cancer at 14 Common Sites in Japanese
Tóm tắt
Background: Tooth loss has been associated with a higher risk of several types of cancer. To clarify the significance of tooth loss to the risk of 14 common cancers, we conducted a large-scale, case-control study based on the Hospital-based Epidemiologic Research Program at Aichi Cancer Center.
Methods: A total of 5,240 cancer subjects and 10,480 age- and sex-matched noncancer controls were recruited. Patients with 14 types of cancer newly diagnosed from 2000 to 2005 were eligible as case subjects, and new outpatients without cancer in the same time period were eligible as controls. Tooth loss was categorized into four groups: group 1, number of remaining teeth, ≥21; group 2, 9 to 20; group 3, 1 to 8; and group 4, 0. The effect of tooth loss was assessed as odds ratios (OR) with 95% confidence intervals (95% CI) calculated with conditional logistic regression models, with adjustment for potential confounders.
Results: A decreased number of remaining teeth was associated with increased OR of head and neck (OR, 1.68; 95% CI, 0.88-1.93; Ptrend = 0.055), esophageal (OR, 2.36; 95% CI, 1.17-4.75; Ptrend = 0.002), and lung (OR, 1.54; 95% CI, 1.05-2.27; Ptrend = 0.027) cancers.
Conclusions: We showed a significant positive association between tooth loss and the risk of head and neck, esophageal, and lung cancers after adjustment for potential confounding factors. The findings indicate that preventive efforts aimed at the preservation of teeth may decrease the risk of these cancers. (Cancer Epidemiol Biomarkers Prev 2008;17(5):1222–7)
Từ khóa
Tài liệu tham khảo
Shimazaki Y, Soh I, Koga T, Miyazaki H, Takehara T. Risk factors for tooth loss in the institutionalised elderly; a six-year cohort study. Community Dent Health 2003;20:123–7.
Genco R, Offenbacher S, Beck J. Periodontal disease and cardiovascular disease: epidemiology and possible mechanisms. J Am Dent Assoc 2002;133 Suppl:14–22S.
Garrote LF, Herrero R, Reyes RM, et al. Risk factors for cancer of the oral cavity and oro-pharynx in Cuba. Br J Cancer 2001;85:46–54.
Joshipura KJ, Hung HC, Rimm EB, Willett WC, Ascherio A. Periodontal disease, tooth loss, and incidence of ischemic stroke. Stroke 2003;34:47–52.
Zheng TZ, Boyle P, Hu HF, et al. Tobacco smoking, alcohol consumption, and risk of oral cancer: a case-control study in Beijing, People’s Republic of China. Cancer Causes Control 1990;1:173–9.
Bundgaard T, Wildt J, Frydenberg M, Elbrond O, Nielsen JE. Case-control study of squamous cell cancer of the oral cavity in Denmark. Cancer Causes Control 1995;6:57–67.
Zheng W, Blot WJ, Shu XO, et al. Risk factors for oral and pharyngeal cancer in Shanghai, with emphasis on diet. Cancer Epidemiol Biomarkers Prev 1992;1:441–8.
Wang YP, Han XY, Su W, et al. Esophageal cancer in Shanxi Province, People’s Republic of China: a case-control study in high and moderate risk areas. Cancer Causes Control 1992;3:107–13.
Abnet CC, Qiao YL, Mark SD, Dong ZW, Taylor PR, Dawsey SM. Prospective study of tooth loss and incident esophageal and gastric cancers in China. Cancer Causes Control 2001;12:847–54.
Abnet CC, Kamangar F, Dawsey SM, et al. Tooth loss is associated with increased risk of gastric non-cardia adenocarcinoma in a cohort of Finnish smokers. Scand J Gastroenterol 2005;40:681–7.
Stolzenberg-Solomon RZ, Dodd KW, Blaser MJ, Virtamo J, Taylor PR, Albanes D. Tooth loss, pancreatic cancer, and Helicobacter pylori. Am J Clin Nutr 2003;78:176–81.
Michaud DS, Joshipura K, Giovannucci E, Fuchs CS. A prospective study of periodontal disease and pancreatic cancer in US male health professionals. J Natl Cancer Inst 2007;99:171–5.
Tajima K, Hirose K, Inoue M, Takezaki T, Hamajima N, Kuroishi T. A model of practical cancer prevention for out-patients visiting a hospital: the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC). Asian Pac J Cancer Prev 2000;1:35–47.
Hamajima N, Matsuo K, Saito T, et al. Gene-environment interactions and polymorphism studies of cancer risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II). Asian Pac J Cancer Prev 2001;2:99–107.
Inoue M, Tajima K, Takezaki T, et al. Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC). Int J Epidemiol 2003;32:257–62.
Inoue M, Tajima K, Hirose K, et al. Epidemiological features of first-visit outpatients in Japan: comparison with general population and variation by sex, age, and season. J Clin Epidemiol 1997;50:69–77.
Tokudome S, Goto C, Imaeda N, Tokudome Y, Ikeda M, Maki S. Development of a data-based short food frequency questionnaire for assessing nutrient intake by middle-aged Japanese. Asian Pac J Cancer Prev 2004;5:40–3.
Tokudome S, Ikeda M, Tokudome Y, Imaeda N, Kitagawa I, Fujiwara N. Development of data-based semi-quantitative food frequency questionnaire for dietary studies in middle-aged Japanese. Jpn J Clin Oncol 1998;28:679–87.
Imaeda N, Goto C, Tokudome Y, Hirose K, Tajima K, Tokudome S. Reproducibility of a short food frequency questionnaire for Japanese general population. J Epidemiol 2007;17:100–7.
Tokudome Y, Goto C, Imaeda N, et al. Relative validity of a short food frequency questionnaire for assessing nutrient intake versus three-day weighed diet records in middle-aged Japanese. J Epidemiol 2005;15:135–45.
Abnet C, Qiao YL, Dawsey SM, et al. Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cance, heart disease, and stroke in a Chinese population-based cohort. Int J Epidemiol 2005;34:467–474.
Hujoel PP, Drangsholt M, Spiekerman C et al. An exploration of the periodontitis-cancer association. Ann Epidemiol 2003;13:312–6.
Nair J, Ohshima H, Nair UJ, Bartsch H. Endogenous formation of nitrosamines and oxidative DNA-damaging agents in tobacco users. Crit Rev Toxicol 1996;26:149–61.
Wayler AH, Kapur KK, Feldman RS, Chauncey HH. Effects of age and dentition status on measures of food acceptability. J Gerontol 1982;37:294–9.
Feldman RS, Kapur KK, Alman JE, Chauncey HH. Aging and mastication: changes in performance and in the swallowing threshold with natural dentition. J Am Geriatr Soc 1980;28:97–103.
Chauncey HH, Muench ME, Kapur KK, Wayler AH. The effect of the loss of teeth on diet and nutrition. Int Dent J 1984;34:98–104.
Mackillop WJ, Zhang-Salomons J, Boyd CJ, Groome PA. Associations between community income and cancer incidence in Canada and the United States. Cancer 2000;89:901–12.