TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy

Springer Science and Business Media LLC - Tập 7 Số 5 - Trang 449-459 - 2002
Wajant, H.1, Pfizenmaier, K.1, Scheurich, P.1
1Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany

Tóm tắt

TNF-related apoptosis-inducing ligand (TRAIL/APO-2L) is a typical member of the TNF ligand family that induces apoptosis by activating the death receptors TRAIL-R1 and TRAIL-R2. TRAIL has attracted great attention in recent years as a promising anti cancer reagent because recombinant soluble TRAIL derivatives induce apoptosis in a broad range of tumor cells but not or only rarely in non-transformed cells. In this review we will address the putative role of TRAIL in cancer treatment in the light of the emerging importance of TRAIL in tumor surveillance and discuss the molecular basis of the cooperation of TRAIL and chemotherapeutic drugs. In particular, we debate controversial data in the literature concerning the cytotoxicity of different TRAIL derivatives on primary human cells.

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citation_journal_title=Nat Med; citation_title=Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions; citation_author=D Lawrence, Z Shahrokh, S Marsters; citation_volume=7; citation_publication_date=2001; citation_pages=383-385; citation_id=CR101

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citation_journal_title=Cancer Res; citation_title=Regulation of tumor necrosis factor-related apoptosis-inducing ligand sensitivity in primary and transformed human keratinocytes; citation_author=M Leverkus, M Neumann, T Mengling; citation_volume=60; citation_publication_date=2000; citation_pages=553-559; citation_id=CR105

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citation_journal_title=Oncogene; citation_title=Tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) triggers apoptosis in normal prostate epithelial cells; citation_author=A Nesterov, Y Ivashchenko, AS Kraft; citation_volume=21; citation_publication_date=2002; citation_pages=1135-1140; citation_id=CR107

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citation_journal_title=Surgery; citation_title=Butyrate sensitizes human colon cancer cells to TRAIL-mediated apoptosis; citation_author=A Hernandez, R Thomas, F Smith; citation_volume=130; citation_publication_date=2001; citation_pages=265-272; citation_id=CR109

citation_journal_title=Oncogene; citation_title=Sodium nitroprusside enhances TRAIL-induced apoptosis via a mitochondriadependent pathway in human colorectal carcinoma CX-1 cells; citation_author=YJ Lee, KH Lee, HR Kim; citation_volume=20; citation_publication_date=2001; citation_pages=1476-1485; citation_id=CR110

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citation_journal_title=Clin Cancer Res; citation_title=Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis; citation_author=AR Jazirehi, CP Ng, XH Gan, G Schiller, B Bonavida; citation_volume=7; citation_publication_date=2001; citation_pages=3874-3883; citation_id=CR115

citation_journal_title=Oncogene; citation_title=CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release; citation_author=TA Rohn, B Wagenknecht, W Roth; citation_volume=20; citation_publication_date=2001; citation_pages=4128-4137; citation_id=CR116

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citation_journal_title=Eur J Cancer; citation_title=Trail activity in human ovarian cancer cells: Potentiation of the action of cytotoxic drugs; citation_author=S Vignati, A Codegoni, F Polato, M Broggini; citation_volume=38; citation_publication_date=2002; citation_pages=177-183; citation_id=CR118

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citation_journal_title=Cancer Res; citation_title=Chemotherapy augments TRAIL-induced apoptosis in breast cell lines; citation_author=MM Keane, SA Ettenberg, MM Nau, EK Russell, S Lipkowitz; citation_volume=59; citation_publication_date=1999; citation_pages=734-741; citation_id=CR120

citation_journal_title=Proc Natl Acad Sci USA; citation_title=Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy; citation_author=AM Chinnaiyan, U Prasad, S Shankar; citation_volume=97; citation_publication_date=2000; citation_pages=1754-1759; citation_id=CR121

citation_journal_title=Oncogene; citation_title=Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL; citation_author=C Belka, B Schmid, P Marini; citation_volume=20; citation_publication_date=2001; citation_pages=2190-2196; citation_id=CR122

citation_journal_title=Cancer Res; citation_title=Apo2 ligand/TNF-related apoptosisinducing ligand and death receptor 5 mediate the apoptotic signaling induced by ionizing radiation in leukemic cells; citation_author=B Gong, A Almasan; citation_volume=60; citation_publication_date=2000; citation_pages=5754-5760; citation_id=CR123

citation_journal_title=Cancer Res; citation_title=Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression; citation_author=A Eggert, MA Grotzer, TJ Zuzak; citation_volume=61; citation_publication_date=2001; citation_pages=1314-1319; citation_id=CR124

citation_journal_title=Oncogene; citation_title=Resistance to TRAILinduced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression; citation_author=MA Grotzer, A Eggert, TJ Zuzak; citation_volume=19; citation_publication_date=2000; citation_pages=4604-4610; citation_id=CR125

citation_journal_title=Clin Cancer Res; citation_title=Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells; citation_author=H Matsuzaki, BM Schmied, A Ulrich; citation_volume=7; citation_publication_date=2001; citation_pages=407-414; citation_id=CR126

citation_journal_title=Clin Cancer Res; citation_title=Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells; citation_author=R Nimmanapalli, M Porosnicu, D Nguyen; citation_volume=7; citation_publication_date=2001; citation_pages=350-357; citation_id=CR127

citation_journal_title=Cancer Res; citation_title=Pretreatment with paclitaxel enhances apo-2 ligand/tumor necrosis factor-related apoptosisinducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels; citation_author=R Nimmanapalli, CL Perkins, M Orlando, E O'Bryan, D Nguyen, KN Bhalla; citation_volume=61; citation_publication_date=2001; citation_pages=759-763; citation_id=CR128

citation_journal_title=Cancer Gene Ther; citation_title=Resistance of prostate cancer cells to soluble TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) can be overcome by doxorubicin or adenoviral delivery of full-length TRAIL; citation_author=C Voelkel-Johnson, DL King, JS Norris; citation_volume=9; citation_publication_date=2002; citation_pages=164-172; citation_id=CR129

citation_journal_title=Cell Death Differ; citation_title=Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan; citation_author=M Dejosez, U Ramp, C Mahotka; citation_volume=7; citation_publication_date=2000; citation_pages=1127-1136; citation_id=CR130

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citation_journal_title=Hepatology; citation_title=Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines; citation_author=T Yamanaka, K Shiraki, K Sugimoto; citation_volume=32; citation_publication_date=2000; citation_pages=482-490; citation_id=CR132

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