TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese

Journal of Neural Transmission - Tập 121 - Trang 283-287 - 2013
Rui-Chun Lu1, Hao Wang2, Meng-Shan Tan3, Jin-Tai Yu1,3, Lan Tan1,3
1Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, People’s Republic of China
2Department of Oncology, The Affiliated Hospital of the Medical College of Qingdao University, Qingdao, China
3Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics, Ocean University of China, Qingdao, China

Tóm tắt

Recent large genome-wide association studies have found variants in TMEM106B (top SNP rs1990622) as a strong risk factor for frontotemporal lobar degeneration. Moreover, the TMEM106B risk variant is also implicated in the pathologic presentation of Alzheimer’s disease (AD). Here, we evaluated the association between TMEM106B rs1990622 polymorphism and late-onset AD (LOAD) in a Northern Han Chinese population consists of 1,133 LOAD patients and 1,159 controls. Our data demonstrate that TMEM106B and APOE interact to increase AD risk.

Tài liệu tham khảo

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