THE URINARY EXCRETION OF ADRENALINE AND NORADRENALINE BY RATS UNDER VARIOUS EXPERIMENTAL CONDITIONS

Wiley - Tập 13 Số 1 - Trang 35-43 - 1958
T. B. B. Crawford1, W Law1,2
1Department of Pharmacology, University of Edinburgh
2Department of Pharmacology, University of Rangoon, Burma.

Tóm tắt

A study has been made of the excretion of adrenaline and noradrenaline in the urine of normal male rats and in the urine of these animals after the subcutaneous injection of saline, adrenaline, noradrenaline, morphine, insulin, iproniazid and thyroxine. The effects of thyroidectomy, adrenal demedullation and ether anaesthesia on the urinary output of adrenaline and noradrenaline have also been investigated. The findings are discussed against the background of the known effects of these treatments on the activity of the sympathetic nervous system.The results demonstrate that urinary adrenaline and noradrenaline estimations in the rat can, under favourable conditions, serve as an indicator of an alteration of sympathetic activity following the administration of a drug or some other deviation from normal.

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Tài liệu tham khảo

10.3109/13813455109145016

Blaschko H., 1952, Pharmacol. Rev., 4, 415

Burn J. H., 1951, Irish. J. med. Sci., 345

10.1136/bmj.1.4762.784

10.1111/j.1476-5381.1950.tb00591.x

10.1113/jphysiol.1925.sp002230

10.1111/j.2042-7158.1958.tb10290.x

10.1111/j.1476-5381.1951.tb00614.x

10.1111/j.1748-1716.1954.tb01155.x

10.1113/jphysiol.1912.sp001521

10.1210/jcem-16-2-222

10.1111/j.1748-1716.1954.tb01107.x

10.1111/j.1748-1716.1951.tb00765.x

10.1111/j.1476-5381.1951.tb00640.x

Euler U. S., 1952, Metabolism, 1, 528

10.1111/j.1748-1716.1954.tb01093.x

Euler U. S., 1955, Acta physiol. scand., 33, 26

10.3109/13813455009144946

10.1111/j.1476-5381.1949.tb00566.x

10.1016/0002-9343(51)90332-4

Goldenberg M., 1951, J. clin. Invest., 30, 641

Hökfelt B., 1951, Acta physiol. scand., 25

10.1111/j.1476-5381.1954.tb00849.x

10.1111/j.1600-0773.1949.tb03389.x

10.1111/j.1600-0773.1950.tb03460.x

Millar R. A., 1956, J. Pharmacol., 118, 435

10.1111/j.1476-5381.1952.tb00728.x

10.3109/00365515509134088

Pitkänen M‐E., 1956, Acta physiol. scand., 38

Schayer R. W., 1951, J. biol. Chem., 189, 301, 10.1016/S0021-9258(18)56120-2

Schayer R. W., 1951, J. biol. Chem., 192, 875, 10.1016/S0021-9258(19)77810-7

10.3181/00379727-84-20541

Schayer R. W., 1952, J. biol., Chem., 198, 545, 10.1016/S0021-9258(18)55509-5

Schayer R. W., 1953, J. biol., Chem., 202, 425, 10.1016/S0021-9258(19)57143-5

Schayer R. W., 1954, J. biol., Chem., 210, 259, 10.1016/S0021-9258(18)65450-X

10.1111/j.1476-5381.1952.tb00694.x

10.1084/jem.24.6.709

Stewart G. N., 1922, J. Pharmacol., 19, 59

10.1111/j.1476-5381.1953.tb01348.x

10.1126/science.117.3050.663

10.1113/jphysiol.1947.sp004219

10.1111/j.1476-5381.1952.tb01329.x

10.1113/jphysiol.1952.sp004820

10.1113/jphysiol.1954.sp005064

10.1111/j.1476-5381.1951.tb00641.x

10.3181/00379727-81-19910

10.1007/BF02174413