THE ROLE OF LONG-RANGE FORCES IN THE COHESION OF LIPOPROTEINS

Canadian Science Publishing - Tập 40 Số 9 - Trang 1287-1298 - 1962
Lionel Salem1
1Department of Chemistry, Harvard University, 12 Oxford Street, Cambridge, Mass

Tóm tắt

The various long-range forces which are effective between molecules in their electronic ground states are examined. Orders of magnitude are given for those forces which should occur in the interaction of lipide and protein chains. It is found that electrostatic forces should be responsible for bringing and holding together protein and lipide components, but London – Van der Waals dispersion forces are probably of paramount importance in maintaining the lipide chains together in micelles or double layers.Special attention is drawn to the dispersion forces and to the conditions under which these forces are locally additive; one can calculate accurate values of the dispersion energy of interaction between saturated hydrocarbon chains at short distances (a few angstroms apart) by adding all the bond–bond interactions. A general expression is given for the dispersion energy between two parallel and opposed chains built out of identical units, and numerical values are given for the case of closely packed hydrocarbon chains.The total attraction energy is extremely sensitive to the intermolecular distance. The role of this "distance-specificity" in interactions involving unsaturated fatty acid chains and its contribution to the stability of lipoproteins is briefly examined.

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Tài liệu tham khảo

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Canadian Science Publishing

Tập 40 Số 9

1287-1298

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