TELOCYTES – a case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal‐Like Cells (ICLC) to TELOCYTES
Tóm tắt
Ramon y Cajal discovered a particular cell type in the gut, which he named ‘interstitial neurons’ more that 100 years ago. In the early 1970s, electron microscopy/electron microscope (EM) studies showed that indeed a special interstitial cell type corresponding to the cells discovered by Cajal is localized in the gut muscle coat, but it became obvious that they were not neurons. Consequently, they were renamed ‘interstitial cells of Cajal’ (ICC) and considered to be pace‐makers for gut motility. For the past 10 years many groups were interested in whether or not ICC are present outside the gastrointestinal tract, and indeed, peculiar interstitial cells were found in: upper and lower urinary tracts, blood vessels, pancreas, male and female reproductive tracts, mammary gland, placenta, and, recently, in the heart as well as in the gut. Such cells, now mostly known as interstitial Cajal‐like cells (ICLC), were given different and confusing names. Moreover, ICLC are only apparently similar to canonical ICC. In fact, EM and cell cultures revealed very particular features of ICLC, which unequivocally distinguishes them from ICC and all other interstitial cells: the presence of 2–5 cell body prolongations that are very thin (less than 0.2 μm, under resolving power of light microscopy), extremely long (tens to hundreds of μm), with a moniliform aspect (many dilations along), as well as caveolae. Given the unique dimensions of these prolongations (very long and very thin) and to avoid further confusion with other interstitial cell types (
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Tài liệu tham khảo
Ramon y CajalS.Histologie du Systeme Nerveux de L’Homme et des Vertebres.Volume 2. Paris :A. Maloine;1911.
Faussone Pellegrini MS, 1977, Ultrastructure of the tunica muscularis of the cardial portion of the human esophagus and stomach, with special reference to the so‐called Cajal’s interstitial cells, Arch Ital Anat Embriol., 82, 157
Faussone‐Pellegrini MS, 2005, Interstitial cells of Cajal: once negligible players, now blazing protagonists, Ital J Anat Embryol., 110, 11
Lecoin L, 1996, Origin of the c‐kit‐positive interstitial cells in the avian bowel, Development., 122, 725, 10.1242/dev.122.3.725
Misra R, 2008, Serendipity and Science, Science Reporter., 45, 9
Cretoiu SM, 2010, Interstitial Cajal‐like cells of human Fallopian tube express estrogen and progesterone receptors, J Mol Histol.
WaandersF.Constructions and meanings of Tελoς. The history of TEΛOΣ and TEΛEΣ in ancient Greek. Amsterdam :B.R. Grüner Publishing Co. 1983. pp.231–7.
BorchardtT KostinS.Plastizitat von Herzmusklezellen des Molches. Max‐Plack‐Gesellschaft Entwicklungs‐& Evolutionsbiologie.2007;237–43.
PopescuLM GherghiceanuM KostinS Faussone‐PellegriniMS.Cardiac telocytes (Interstitial Cajal‐Like Cells) and heart renewing. In “Adaptation Biology and Medicine: Cell Adaptations and Challenges” Editors.WangP KuoC‐H TakedaN SingalPK;Narosa Publishers New Delhi India .2010; Vol.6(In Press).