Systematic Review and Meta-Analysis of the Association between Ambient Nitrogen Dioxide and Respiratory Disease in China

International Journal of Environmental Research and Public Health - Tập 14 Số 6 - Trang 646
Jiyao Sun1, Andrew J. Barnes2, Dongyang He1, Meng Wang1, Jian Wang1
1School of Health Care Management, Shandong University, Key Laboratory of Health Economics and Policy Research, National Health and Family Planning Commission of People’s Republic of China (NHFPC), Shandong University, 44 West Wenhua Road, Jinan 250012, China
2Department of Health Behavior and Policy, School of Medicine, Virginia Commonwealth University, 830 E Main St., Richmond, VA 23219, USA

Tóm tắt

Objective: This study aimed to assess the quantitative effects of short-term exposure of ambient nitrogen dioxide (NO2) on respiratory disease (RD) mortality and RD hospital admission in China through systematic review and meta-analysis. Methods: A total of 29 publications were finally selected from searches in PubMed, Web of Science, CNKI and Wanfang databases. Generic inverse variance method was used to pool effect estimates. Pooled estimates were used to represent the increased risk of RD mortality and RD hospital admission per 10 μg/m3 increase in NO2 concentration. Results: Positive correlations were found between short-term NO2 exposure and RD in China. RD mortality and RD hospital admission respectively increased by 1.4% (95% CI: 1.1%, 1.7%) and 1.0% (95% CI: 0.5%, 1.5%) per 10 μg/m3 increase in NO2 concentration. Differences were observed across geographic regions of China. The risk of RD mortality due to NO2 was higher in the southern region (1.7%) than in the north (0.7%). Conclusions: Evidence was found that short-term exposure to NO2 was associated with an increased risk of RD mortality and RD hospital admission in China and these risks were more pronounced in the southern regions of the country, due in part to a larger proportion of elderly persons with increased susceptibility to NO2 in the population compared with the north.

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Tài liệu tham khảo

Liu, 2016, Spatial—Temporal analysis of air pollution, climate change, and total mortality in 120 cities of China, 2012–2013, Front. Public Health, 4, 123, 10.3389/fpubh.2016.00143

Samet, 2007, Health effects associated with exposure to ambient air pollution, J. Toxicol. Environ. Health Part A, 70, 227, 10.1080/15287390600884644

Chen, 2012, Associations between short-term exposure to nitrogen dioxide and mortality in 17 Chinese cities: The China Air Pollution and Health Effects Study (CAPES), Environ. Int., 45, 32, 10.1016/j.envint.2012.04.008

Kan, 2008, Season, sex, age, and education as modifiers of the effects of outdoor air pollution on daily mortality in Shanghai, China: The Public Health and Air Pollution in Asia (PAPA) Study, Environ. Health Perspect., 116, 1183, 10.1289/ehp.10851

Samoli, 2006, Short-term effects of nitrogen dioxide on mortality: An analysis within the APHEA project, Eur. Respir. J., 27, 1129, 10.1183/09031936.06.00143905

Rajarathnam, 2011, Part 2. Time-series study on air pollution and mortality in Delhi, Res. Rep., 157, 47

Blomberg, 1997, The inflammatory effects of 2 ppm NO2 on the airways of healthy subjects, Am. J. Respir. Crit. Care Med., 156, 418, 10.1164/ajrccm.156.2.9612042

Tao, 2012, Estimated acute effects of ambient ozone and nitrogen dioxide on mortality in the pearl river delta of Southern China, Environ. Health Perspect., 120, 393, 10.1289/ehp.1103715

Wong, 2002, Associations between daily mortalities from respiratory and cardiovascular diseases and air pollution in Hong Kong, China, Occup. Environ. Med., 59, 30, 10.1136/oem.59.1.30

Yang, 2004, Relationship between air pollution and daily mortality in a subtropical city: Taipei, Taiwan, Environ. Int., 30, 519, 10.1016/j.envint.2003.10.006

Wong, 1999, Air pollution and hospital admissions for respiratory and cardiovascular diseases in Hong Kong, Occup. Environ. Med., 56, 679, 10.1136/oem.56.10.679

Zhang, 2014, Impact of haze and air pollution-related hazards on hospital admissions in Guangzhou, China, Environ. Sci. Pollut. Res. Int., 21, 4236, 10.1007/s11356-013-2374-6

Tao, Y. (2009). Physical and Chemical Characteristics of Atmospheric Particulate Matter and Their Impact on Human Health in Lanzhou, Lanzhou University.

Liu, J.Y. (2014). Time-Series Analysis of Air Pollution and Health Effect of the Residents in Hangzhou, Hangzhou Dianzi University.

Sheehan, 2016, Ambient air pollution epidemiology systematic review and meta-analysis: A review of reporting and methods practice, Environ. Int., 92, 647, 10.1016/j.envint.2016.02.016

Stieb, 2002, Meta-analysis of time-series studies of air pollution and mortality: Effects of gases and particles and the influence of cause of death, age, and season, J. Air Waste Manag. Assoc., 52, 470, 10.1080/10473289.2002.10470794

Stieb, 2003, Meta-analysis of time-series studies of air pollution and mortality: Update in relation to the use of generalized additive models, J. Air Waste Manag. Assoc., 53, 258, 10.1080/10473289.2003.10466149

Shin, 2008, A temporal, multicity model to estimate the effects of short-term exposure to ambient air pollution on health, Environ. Health Perspect., 116, 1147, 10.1289/ehp.11194

Touloumi, 1997, Short-term effects of ambient oxidant exposure on mortality: A combined analysis within the APHEA project, Am. J. Epidemiol., 146, 177, 10.1093/oxfordjournals.aje.a009249

Zmirou, 1998, Time-series analysis of air pollution and cause-specific mortality, Epidemiology, 9, 495, 10.1097/00001648-199809000-00005

Lu, 2015, Systematic review and meta-analysis of the adverse health effects of ambient PM2.5 and PM10 pollution in the Chinese population, Environ. Res., 136, 196, 10.1016/j.envres.2014.06.029

Shang, 2013, Systematic review of Chinese studies of short-term exposure to air pollution and daily mortality, Environ. Int., 54, 100, 10.1016/j.envint.2013.01.010

Lai, H.K., Tsang, H., and Wong, C.M. (2013). Meta-analysis of adverse health effects due to air pollution in Chinese populations. BMC Public Health, 13.

Liu, 2015, A Meta analysis on the associations between air pollution and respiratory mortality in China, Chin. J. Epidemiol., 36, 889

Wang, X.Y., Jiao, S.L., Wang, W.C., Zeng, X., Hu, C.P., and Wang, L. (2016, January 13–14). The effect of air pollution on hospital admission in Wuhan in 2013–2015. Proceedings of the Annual Meeting in 2016 of the Chinese Society of Environmental Sciences, Haikou, China.

Yang, Y. (2015). Study on Air Pollution and Population Health in Beijing, Peking Union Medical College.

Zeng, 2015, Acute effects of SO2 and NO2 on mortality in the six cities of China, Chin. J. Prev. Med., 49, 1085

Qiu, 2015, Air pollution and mortality: Effect modification by personal characteristics and specific cause of death in a case-only study, Environ. Pollut., 199, 192, 10.1016/j.envpol.2015.02.002

He, 2016, Ambient air pollution and years of life lost in Ningbo, China, Sci. Rep., 6, 22485, 10.1038/srep22485

Benichou, J. (2006). Attributable Risk, John Wiley & Sons, Ltd.

Zheng, X.Y., Ding, H., Jiang, L.N., Chen, S.W., Zheng, J.P., Qiu, M., Zhou, Y.X., Chen, Q., and Guan, W.J. (2015). Association between air pollutants and asthma emergency room visits and hospital admissions in time series studies: A systematic review and meta-analysis. PLoS ONE, 10.

Moher, 2014, Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement, J. Chin. Integr. Med., 18, 889

Greenland, 1987, Quantitative methods in the review of epidemiologic literature, Epidemiol. Rev., 9, 1, 10.1093/oxfordjournals.epirev.a036298

Atkinson, 2012, Systematic review and meta-analysis of epidemiological time-series studies on outdoor air pollution and health in Asia, Air Qual. Atmos. Health, 5, 383, 10.1007/s11869-010-0123-2

Song, X., Liu, Y., Hu, Y., Zhao, X., Tian, J., Ding, G., and Wang, S. (2016). Short-term exposure to air pollution and cardiac arrhythmia: A meta-analysis and systematic review. Int. J. Environ. Res. Public Health, 13.

Song, 2014, The global contribution of outdoor air pollution to the incidence, prevalence, mortality and hospital admission for chronic obstructive pulmonary disease: A systematic review and meta-analysis, Int. J. Environ. Res. Public Health, 11, 11822, 10.3390/ijerph111111822

Egger, 1997, Bias in meta-analysis detected by a simple, graphical test, BMJ, 315, 629, 10.1136/bmj.315.7109.629

Duval, 2000, Trim and fill: A simple funnel-plot–based method of testing and adjusting for publication bias in meta-analysis, Biometrics, 56, 455, 10.1111/j.0006-341X.2000.00455.x

World Health Organization (2005). WHO Air Quality Guidelines for Particulate Matter, Ozone, Nitrogen Dioxide and Sulfur Dioxide, World Health Organization. Summary of Risk Assessment.

Chen, 2010, Ambient air pollution and daily mortality in Anshan, China: A time-stratified case-crossover analysis, Sci. Total Environ., 408, 6086, 10.1016/j.scitotenv.2010.09.018

Zhang, 2011, Study on the association between ambient air pollution and daily cardiovascular and respiratory mortality in an urban district of Beijing, Int. J. Environ. Res. Public Health, 8, 2109, 10.3390/ijerph8062109

Zhang, 2011, Relationship between air pollution and daily respiratory system disease mortality in Chaoyang District, Beijing: A time-series analysis, J. Environ. Health, 21, 223

Zhao, Y. (2007). Study on Health Effect and Economic Loss on Urban Citizens Caused by Air Pollution, China University of Geosciences.

Liu, 2014, Relationships between ambient nitrogen dioxide and population mortality of respiratory disease in Beijing, J. Environ. Health, 31, 565

Huang, 2012, Time-series analysis on the acute mortality affected by air pollution, in the city of Guangzhou, 2004–2008, Zhonghua Liu Xing Bing Xue Za Zhi, 33, 210

Yu, 2012, Effect of ambient air pollution on daily mortality rates in Guangzhou, China, Atmos. Environ., 46, 528, 10.1016/j.atmosenv.2011.07.055

Wong, 2001, Effect of air pollution on daily mortality in Hong Kong, Environ. Health Perspect., 109, 335, 10.1289/ehp.01109335

Wong, 2007, Public Health and Air Pollution in Asia (PAPA): A multicity study of short-term effects of air pollution on mortality, Environ. Health Perspect., 116, 1195, 10.1289/ehp.11257

Tsai, 2003, Relationship between air pollution and daily mortality in a tropical city: Kaohsiung, Taiwan, J. Toxicol. Environ. Health Part A, 66, 1341, 10.1080/15287390306389

Jia, 2004, Association of air pollution with daily mortality in Zhabei District of Shanghai: A case, crossover analysis, J. Environ. Health, 21, 279

Zhang, 2010, Time-series analysis on the association between gaseous air pollutants and daily mortality in urban residents in Tianjin, Epidemiology, 31, 1158

He, X.S. (2014). Epidemiological Study on the Assocaition of Air Pollution and Its Constituents with the Cardiopulmonary Mortality and the Risk of Coronary Heart Disease, Huazhong University of Science and Technology.

Qian, 2007, Short-term effects of gaseous pollutants on cause-specific mortality in Wuhan, China, J. Air Waste Manag. Assoc., 57, 785, 10.3155/1047-3289.57.7.785

Lan, L. (2013). Effects of Air Pollution on Public Health in Jinchang, Lanzhou University.

Chen, 2010, Ambient air pollution and hospital admission in Shanghai, China, J. Hazard. Mater., 181, 234, 10.1016/j.jhazmat.2010.05.002

Bao, 2013, Time-series analysis on relationship between air pollution and daily hospital for respiratory system diseases in Urumqi, J. Xinjiang Med. Univ., 36, 537

Chiusolo, 2011, Short-term effects of nitrogen dioxide on mortality and susceptibility factors in 10 Italian Cities: The EpiAir study, Environ. Health Perspect., 119, 1233, 10.1289/ehp.1002904

Kinney, 1991, Associations of daily mortality and air pollution in Los Angeles County, Environ. Res., 54, 99, 10.1016/S0013-9351(05)80094-5

Fusco, 2001, Air pollution and hospital admissions for respiratory conditions in Rome, Italy, Eur. Respir. J., 17, 1143, 10.1183/09031936.01.00005501

Spix, 1998, Short-term effects of air pollution on hospital admissions of respiratory diseases in Europe: A quantitative summary of APHEA study results, Arch. Environ. Health, 53, 54, 10.1080/00039899809605689

Wang, 2013, Research on the measure of chinese population aging level and spatial correlation, Areal Res. Dev., 3, 138

Qian, 2011, Clinical characteristics of respiratory diseases in the elderly, Chin. J. Health Care Med., 13, 177

Chen, R.J. (2013). The Health Effects of Complex Air Pollution in 17 Chinese Cities, Fudan University.

Sarnat, 2001, Gaseous pollutants in particulate matter epidemiology: Confounders or surrogates?, Environ. Health Perspect., 109, 1053, 10.1289/ehp.011091053

Sarnat, 2005, Ambient gas concentrations and personal particulate matter exposures: Implications for studying the health effects of particles, Epidemiology, 16, 385, 10.1097/01.ede.0000155505.04775.33

Seaton, 2003, Hypothesis: Ill health associated with low concentrations of nitrogen dioxide—An effect of ultrafine particles?, Thorax, 58, 1012, 10.1136/thorax.58.12.1012

Anderson, 2005, Ambient particulate matter and health effects: Publication bias in Studies of short-term associations, Epidemiology, 16, 155, 10.1097/01.ede.0000152528.22746.0f

Zhang, 2001, Case-crossover design, Chin. J. Epidemiol., 22, 304

Zhang, 2016, Short-term exposure to air pollution and morbidity of COPD and asthma in East Asian area: A systematic review and meta-analysis, Environ. Res., 148, 15, 10.1016/j.envres.2016.03.008

Dominici, 2010, Protecting human health from air pollution: Shifting from a single-pollutant to a multipollutant approach, Epidemiology, 21, 187, 10.1097/EDE.0b013e3181cc86e8

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International Journal of Environmental Research and Public Health

Tập 14 Số 6

646

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