Synthesis of Glycopeptides, Partial Structures of Biological Recognition Components [New Synthetic Methods (67)]
Tóm tắt
Glycopeptides are partial structures of the connecting regions of glycoproteins and, like these, always contain glycosidic bonds between the carbohydrate and peptide parts. Glycoproteins are not only widely distributed but are also decisive factors in post‐translational biological selectivity, especially in biological recognition. Targeted syntheses of glycopeptides require stereoselective formation of the glycosidic bonds between the carbohydrate and the peptide parts and protective group methods that enable selective deblocking of only one functional group in these polyfunctional molecules. These heavy demands have been met by the well‐established use of benzylic protective groups, which can be removed by hydrogenolysis, combined with the use of base‐labile 2‐phosphonioethoxycarbonyl (Peoc) or 9‐fluorenylmethoxycarbonyl (Fmoc) protective groups or of bromoethyl esters, which can be removed under neutral conditions. The acidolysis of
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