Synthesis and in vitro antimicrobial activity of new steroidal hydrazone derivatives

Future Journal of Pharmaceutical Sciences - Tập 8 - Trang 1-10 - 2022
Shailesh Mistry1, Akhilesh Kumar Singh1
1Parul Institute of Applied Science, Parul University, Vadodara, India

Tóm tắt

For many years, various drugs have been used for the treatment of infectious diseases but some bacterial microorganisms have induced resistance to several drugs. In a search of new antimicrobial agents, a series of new steroidal hydrazones were designed and synthesized. The structures of the compounds were established based on the spectral data. The in vitro antimicrobial activity of some newly synthesized compounds against bacteria and fungi was studied. New compounds showed better or similar antimicrobial activity. Designing more efficient steroidal hydrazones from ketosteroid based on the current study may successfully lead to the development of antimicrobial agent.

Tài liệu tham khảo

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