Synthesis And Antiviral Activity Of 2'-Deoxy-2'-Fluoro-L-Arabinofuranosyl 1,2,3-Triazole Derivatives

Süreyya Ölgen1, Chung K. Chu2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ankara, Tandogan, Ankara 06100 Turkey
2Center for Drug Discovery, Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602 U. S. A.

Tóm tắt

The title compounds were prepared by building up the triazole ring at the anomeric position via the glycosyl azides 5 a,b. The anomeric configurations of these nucleosides were assigned by using 1H, 13C and NOESY NMR spectroscopy. The synthesized nucleosides were evaluated against HIV-1 and HBV

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