Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection
Tóm tắt
The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase.
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Tài liệu tham khảo
BRINDLEY P.J., 1987, The chemotherapeutic effect of praziquantel against Schistosoma mansoni is dependent on host antibody response, J. Immunol., 139, 215
COELHO P.M.Z., 1995, Schistosoma mansoni: reinfection and concomitant immunity in mice: Importance of perfusion time after challenge infection for evaluation of immunoprotection, Mem. Inst. Oswaldo Cruz, 90, 507, 10.1590/S0074-02761995000400014
FARAH I.O., 2000, Schistosoma mansoni in mice: the pattern of primary cercarial exposure determines whether a secondary infection post-chemotherapy elicits a T helper 1-or a T helper 2-associated immune response, Scand. J. Immunol., 51, 237, 10.1046/j.1365-3083.2000.00667.x
GONNERT R., 1977, Praziquantel, a new broad spectrum antischistosomal agent, Z. Parasitenk., 52, 129, 10.1007/BF00389899
HARNETT W., 1986, Increased exposure of parasite antigens at the surface of adult male Schistosoma mansoni exposed to praziquantel in vitro, Parasitology, 93, 401, 10.1017/S0031182000051568
MEHLHORN H., 1981, In vivo and in vitro experiments on the effects of praziquantel on Schistosoma mansoni: A light and electron microscopic study, Arzneimittel-Forschung Drug Res., 31, 544
PELLEGRINO J., 1956, Técnica de perfusão para colheita de Schistosoma mansoni em cobaias experimentalmente infectadas, Rev. bras. Malar., 8, 589
RIBEIRO F., 1998, Membrane internalization processes in different stages of Schistosoma mansoni as shown by a styryl dye (Fei Mao 1-43), Parasitology, 116, 51, 10.1017/S0031182097001960
RIBEIRO F., 1998, The effect of praziquantel treatment on glutathione concentration in Schistosoma mansoni, Parasitology, 116, 229, 10.1017/S0031182097002291
SCHEPERS H., 1988, Mode of insertion of praziquantel and derivatives into lipid membranes, Biochem. Pharmacol., 37, 1615, 10.1016/0006-2952(88)90026-3
SMITHERS S.R., 1969, Immunity in schistosomiasis, Ann. N. Y. Acad. Sci., 160, 826, 10.1111/j.1749-6632.1969.tb15904.x
WILSON R.A., 1986, Migration of the schistosomula of Schistosoma mansoni in mice vaccinated with radiation-attenuated cercariae, and normal mice: an attempt to identify the timing and the site of parasite death, Parasitology, 92, 101, 10.1017/S0031182000063484