Swine as Models in Biomedical Research and Toxicology Testing

Veterinary Pathology - Tập 49 Số 2 - Trang 344-356 - 2012
M. Michael Swindle1, Andy Makin2, Alan J. Herron3, Fred J. Clubb4, Kendall S. Frazier5
1Medical University of South Carolina, Department of Comparative Medicine, MSC 777, 114 Doughty St, Charleston, SC 29425-7770, USA.
2LAB Research, Copenhagen, Denmark
3Center for Comparative Medicine and Department of Pathology & Immunology Baylor College of Medicine, Houston, TX
4Texas A&M University, College of Veterinary Medicine, College Station, TX
5GlaxoSmithKline, King of Prussia, PA

Tóm tắt

Swine are considered to be one of the major animal species used in translational research, surgical models, and procedural training and are increasingly being used as an alternative to the dog or monkey as the choice of nonrodent species in preclinical toxicologic testing of pharmaceuticals. There are unique advantages to the use of swine in this setting given that they share with humans similar anatomic and physiologic characteristics involving the cardiovascular, urinary, integumentary, and digestive systems. However, the investigator needs to be familiar with important anatomic, histopathologic, and clinicopathologic features of the laboratory pig and minipig in order to put background lesions or xenobiotically induced toxicologic changes in their proper perspective and also needs to consider specific anatomic differences when using the pig as a surgical model. Ethical considerations, as well as the existence of significant amounts of background data, from a regulatory perspective, provide further support for the use of this species in experimental or pharmaceutical research studies. It is likely that pigs and minipigs will become an increasingly important animal model for research and pharmaceutical development applications.

Từ khóa


Tài liệu tham khảo

10.1016/S0828-282X(09)70068-6

10.1053/jcpa.2002.0601

10.1111/1523-1747.ep12556814

10.1016/j.vascn.2010.05.003

Fuss FK, 1991, J Anat, 178, 11

10.1038/sj.jid.5700482

Grehan J, 2000, J Heart Valve Dis, 9, 710

10.1517/17425255.4.6.681

Harig F, 2010, (Sus scrofa domestica)Comp Med, 60, 38

Hendry PJ, 1994, Does septal position affect right ventricular function during left ventricular assist in an experimental porcine model?Circulation, 90, 353

10.1097/00005344-199410000-00019

Kassab GS, 1994, Am J Physiol, 267, H319

Keenan C, 2006, Standard morphologic evaluation of the heart in the laboratory dog and monkeyToxicol Pathol, 34, 67

10.1177/019262330002800208

10.1148/radiol.2262011639

Kurihara-Bergstrom T, 1986, Lab Anim Sci, 36, 396

Kvetina J, 1999, Gen Physiol Biophys, 18, 80

10.1093/ilar.45.3.303

Lehmann H, 1998, Scand J Lab Anim Sci, 25, 59

10.1016/j.neubiorev.2007.02.003

10.1161/CIRCULATIONAHA.109.192667

10.1016/j.etp.2006.03.004

10.1354/vp.43-4-447

Mertz PM, 1990, Clinical and Experimental Approaches to Dermal and Epidermal Repair. Normal and Chronic Wounds, 473

10.1016/S0892-0362(98)00037-3

10.1111/1523-1747.ep12676714

10.1016/S0003-4975(02)03952-8

10.1109/TMAG.2006.879630

10.2133/dmpk.24.404

10.1292/jvms.56.685

10.1293/tox.20.125

10.1097/00007890-199108000-00006

10.1016/S1072-7515(97)00152-X

10.1080/0891693021000010703

10.1016/j.ejvs.2005.07.018

10.1016/0165-2427(94)90135-X

Schantz LD, 1996, Essentials of

Schwartz RS, 2008, Circulation, 1, 143

10.1161/01.CIR.0000033485.20594.6F

Silverstein P, 1976, The Ultrastructure of Collagen: Its Relation to the Healing of Wounds and to the Management of Hypertrophic Scar, 213

10.1111/j.1600-0773.1999.tb00088.x

10.1111/j.1742-7843.2005.pto_148.x

10.2174/138161206776361183

Sullivan T, 2001, Wounds, 13, 24

10.1016/j.etp.2006.03.003

10.1002/jbm.a.31769

Swindle MM, 1988, Experimental Surgery and Physiology: Induced

Swindle MM, 2005, Contemp Topics Lab Anim Sci, 44, 7

Swindle MM, 1998, Scand J Lab Anim Sci, 25, 1

Swindle MM, 1992, Swine as Models in Biomedical Research

10.1201/9781420009156

Tissot RG, 1987, Cancer Res, 47, 5542

10.1007/978-1-4615-5885-9

Vale P, 2002, Heart Metab, 18, 10

10.1177/0192623309358906

Witkamp R, 1998, Scand J Lab Anim Sci, 25, 45

10.1111/j.1524-475X.2007.00223.x

Thông tin
Thông tin xuất bản

Veterinary Pathology

Tập 49 Số 2

344-356

Thông tin tác giả