Susceptibility of mouse skeletal muscles to exercise injuries

Muscle and Nerve - Tập 6 Số 8 - Trang 596-601 - 1983
Antero Salminen1, V. Vihko1
1Division of Muscle Research, Department of Cell Biology, University of Jyväskylä, Jyväskylä, Finland

Tóm tắt

AbstractThe susceptibility to exercise‐induced myopathy was studied by histological and biochemical methods in various skeletal muscles of mice 3–4 days after a single bout of prolonged running. The degree of exercise injuries varied greatly in different muscles. Soleus and the red deep parts of quadriceps femoris were the most severely affected muscles. Extensive or scattered necrosis of muscle fibers was associated with focal inflammation and a five‐ to nine‐fold increase in the activity of β‐glucuronidase in these muscles. Slight necrotic changes and a two‐ to three‐fold increase in the activity of β‐glucuronidase were observed in tibialis anterior, plantaris, and the red deep parts of gastrocnemius. A statistically significant increase in β‐glucuronidase activity was also observed in the white distal part of quadriceps femoris, biceps femoris, gracilis, extensor digitorum longus, and peroneal muscles but necrotic lesions were infrequent in these muscles. The degree of exercise injuries is probably affected by the different recruitment of muscles during running and by the anatomical location of muscles in separate compartments, which could expose them to differnt levels of ischemic compression by postexercise edema.

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Tài liệu tham khảo

10.1007/BF00590489

10.1152/ajplegacy.1973.225.5.1045

Dohm GL, 1982, Increased excretion of urea and N‐methylhistidine by rats and humans after a bout of exercise, J Appl Physiol, 52, 27, 10.1152/jappl.1982.52.1.27

Getzen LC, 1967, Etiology of anterior tibial compartment syndrome, Surg Gynecol Obstet, 125, 347

10.1212/WNL.17.3.216

Hargens AR, 1978, Fluid balance within the canine anterolateral compartment and its relationship to compartment syndromes, J Bone Joint Surg, 60, 499, 10.2106/00004623-197860040-00012

Hecht A, 1975, Histologische und enzymhistochemische Befunde am Skelettmuskel der untrainierten Ratte nach intensiver physischer Belastung, Med Sport (Berl), 15, 270

Highman B, 1963, Effects of exercise and training on serum enzyme and tissue changes in rats, Am J Physiol, 205, 162, 10.1152/ajplegacy.1963.205.1.162

Kuipers H, 1982, Focal lesions in the rat skeletal muscle after submaximal nonexhaustive exercise, Med Sci Sports, 14, 172

10.1007/BF00692055

10.1007/BF00496520

Reneman RS, 1968, The Anterior and the Lateral Compartment Syndrome of the Leg

10.1097/00003086-197511000-00008

10.1007/BF00587923

10.1111/j.1748-1716.1981.tb06787.x

10.1016/0014-4800(83)90098-9

Schumann H‐J, 1972, Überlastungsnekrosen der Skelettmuskulatur nach experimentellem Laufzwang, Zentralbl Allg Pathol, 116, 181

10.1038/icb.1974.13

10.1007/BF00492083

10.1007/BF00584441

Vihko V, 1979, Exhaustive exercise, endurance training and acid hydrolase activity in skeletal muscle, J Appl Physiol, 47, 43, 10.1152/jappl.1979.47.1.43