Successful treatment of a child with t(15;19)‐positive tumor

Pediatric Blood and Cancer - Tập 49 Số 7 - Trang 1015-1017 - 2007
Fredrik Mertens1, Thomas Wiebe2, Catharina Adlercreutz3, Nils Mandahl1, Christopher A. French4
1Department of Clinical Genetics, Lund University Hospital, Lund, Sweden
2Department of Pediatric Oncology, Lund University Hospital, Lund, Sweden.
3Department of Radiology, Center for Medical Imaging and Physiology, Lund University Hospital, Lund, Sweden
4Department of Pathology, Brigham & Women’s Hospital, Boston, Massachusetts

Tóm tắt

AbstractA subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene. Typically, this tumor affects children or young adults, with a predilection for midline head and neck or thoracic structures. The clinical course is invariably fatal, in spite of intensive chemotherapy and radiotherapy. We here present the successful treatment of a 10‐year‐old boy who presented with a BRD4/NUT‐positive undifferentiated tumor in the iliac bone. The patient was selected for combined modality therapy, and has remained in complete continuous remission for close to 13 years. The findings show that t(15;19)‐BRD4/NUT‐positive tumors may arise in locations more typical for other pediatric tumors, such as Ewing sarcoma, and that they not always display epithelial differentiation. More importantly, our results also demonstrate that at least some patients with t(15;19)‐positive tumors may be successfully treated. Pediatr Blood Cancer 2007;49:1015–1017. © 2006 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

10.1200/JCO.2004.02.107

French CA, 2003, BRD4‐NUT fusion oncogene: A novel mechanism in aggressive carcinoma, Cancer Res, 63, 304

Kubonishi I, 1991, Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma, Cancer Res, 51, 3327

Marx A, 2004, World Health Organiziation classification of tumours. Pathology and genetics of tumours of the lung, thymus and heart, 185

10.1002/(SICI)1097-0339(199607)15:1<17::AID-DC5>3.0.CO;2-N

10.1016/S0959-8049(00)00028-9

Thông tin
Thông tin xuất bản

Pediatric Blood and Cancer

Tập 49 Số 7

1015-1017

Thông tin tác giả