Successful intrathecal neurolytic block for the management of cancer pain in a 10-year-old child: a case report

JA Clinical Reports - Tập 7 Số 1 - 2021
Satokuni Tashiro1, Kohei Godai1, Yukihisa Daitoku1, Taishi Sato1, Kei Enohata1, N Kiyonaga1, Kazuyuki Maekawa2, Yuichi Kanmura1
1Department of Anesthesiology and Pain Medicine, Kagoshima University Hospital, Kagoshima, Japan
2Palliative Care Center, Kagoshima University Hospital, Kagoshima, Japan

Tóm tắt

Abstract Background Cancer pain management in children is challenging owing to their unique patient characteristics. We present the case of a 10-year-old girl whose cancer pain was successfully managed using an intrathecal neurolytic block. Case presentation The patient experienced severe cancer pain due to recurrent right ilium osteosarcoma. The tumor progressed rapidly despite chemoradiotherapy and gradually invaded the right lumbar plexus, which resulted in severe neuropathic pain in the right lower extremity. Systemic analgesics failed to attenuate the pain. We performed an intrathecal neurolytic block using 10% phenol-glycerol. The neurolytic block completely relieved her right lower extremity pain. After the block, the patient’s quality of life improved, and she spent her time with family. Conclusions The intrathecal neurolytic block successfully relieved the patient’s cancer pain. Successful intrathecal neurolytic blocks require meticulous pain assessment of individual patients, to avoid possible serious complications such as paresis/paralysis and bladder/bowel dysfunction.

Từ khóa


Tài liệu tham khảo

Deandrea S, Montanari M, Moja L, Apolone G. Prevalence of undertreatment in cancer pain. A review of published literature. Ann Oncol. 2008;19(12):1985–91. https://doi.org/10.1093/annonc/mdn419.

WHO. WHO guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents. 2018. https://apps.who.int/iris/handle/10665/279700 Accessed 8 Mar 2021.

Duffy EA, Dias N, Hendricks-Ferguson V, Hellsten M, Skeens-Borland M, Thornton C, et al. Perspectives on cancer pain assessment and management in children. Semin Oncol Nurs. 2019;35(3):261–73. https://doi.org/10.1016/j.soncn.2019.04.007.

Finnerup NB, Attal N, Haroutounian S, McNicol E, Baron R, Dworkin RH, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162–73. https://doi.org/10.1016/S1474-4422(14)70251-0.

Candido K, Stevens RA. Intrathecal neurolytic blocks for the relief of cancer pain. Best Pract Res Clin Anaesthesiol. 2003;17(3):407–28. https://doi.org/10.1016/S1521-6896(03)00016-8.

Patt RB, Payne R, Farhat GA, Reddy SK. Subarachnoid neurolytic block under general anesthesia in a 3-year-old with neuroblastoma. Clin J Pain. 1995;11(2):143–6. https://doi.org/10.1097/00002508-199506000-00010.

Shimazaki M, Egawa H, Motojima F, Fujimaki K, Hamaguchi S, Okuda Y, et al. Intrathecal phenol block in a child with cancer pain--a case report. Masui. 2003;52(7):756–8.

Haanpaa M, Attal N, Backonja M, Baron R, Bennett M, Bouhassira D, et al. NeuPSIG guidelines on neuropathic pain assessment. Pain. 2011;152(1):14–27. https://doi.org/10.1016/j.pain.2010.07.031.

Lifshitz S, Debacker LJ, Buchsbaum HJ. Subarachnoid phenol block for pain relief in gynecologic malignancy. Obstet Gynecol. 1976;48(3):316–20.

Watanabe A, Yamakage M. Intrathecal neurolytic block in a patient with refractory cancer pain. J Anesth. 2011;25(4):603–5. https://doi.org/10.1007/s00540-011-1141-4.