Subtype distribution of lymphomas in Southwest China: Analysis of 6,382 cases using WHO classification in a single institution
Tóm tắt
The subtype distribution of lymphoid neoplasms in Southwest China was analyzed according to WHO classifications. This study aims to analyze subtype distribution of lymphomas in southwest China.
Lymphoid neoplasms diagnosed within 9 years in a single institution in Southwest China were analyzed according to the WHO classification.
From January 2000 to December 2008, a total number of 6,382 patients with lymphoma were established, of which mature B-cell neoplasms accounted for 56%, mature T- and NK-cell neoplasms occupied 26%, and precursor lymphoid neoplasms and Hodgkin lymphomas were 5% and 13%, respectively. Mixed cellularity (76%) was the major subtype of classical Hodgkin lymphoma; and the bimodal age distribution was not observed. The top six subtypes of non-Hodgkin lymphoma were as follows: diffuse large B-cell lymphoma, extranodal NK/T-cell lymphoma, nasal type, extranodal marginal zone lymphoma of mucosa associated lymphoid tissue, follicular lymphoma, precursor lymphoid neoplasms, and chronic lymphocytic leukemia/small lymphocytic lymphoma. Extranodal lymphomas comprised about half of all cases, and most frequently involved Waldeyer's ring, gastrointestinal tract, sinonasal region and skin.
The lymphoid neoplasms of Southwest China displayed some epidemiologic features similar to those reported in literature from western and Asian countries, as well as other regions of China, whereas some subtypes showed distinct features. The high frequency of mature T/NK cell neoplasms and extranodal lymphomas, especially for extranodal NK/T-cell lymphoma, nasal type, is the most outstanding characteristic of this series.
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Tài liệu tham khảo
Zhang SW, Lei ZL, Li GL, Zou XN, Zhao P, Chen WQ: A Report of Cancer Incidence and Mortality from 34 Cancer Registries in China, 2006. Zhong Guo Zhong Liu. 2010, 19: 356-365.
Anderson JR, Armitage JO, Weisenburger DD: Epidemiology of the non-Hodgkin's lymphomas: distributions of the major subtypes differ by geographic locations. Non-Hodgkin's Lymphoma Classification Project. Ann Oncol. 1998, 9: 717-720. 10.1023/A:1008265532487.
Au WY, Gascoyne RD, Klasa RD, Connors JM, Gallagher RP, Le ND, Loong F, Law CK, Liang R: Incidence and spectrum of non-Hodgkin lymphoma in Chinese migrants to British Columbia. Br J Haematol. 2005, 128: 792-796. 10.1111/j.1365-2141.2005.05387.x.
Vose J, Armitage J, Weisenburger D: International peripheral T-cell and natural killer/T-cell lymphoma study: pathology findings and clinical outcomes. J Clin Oncol. 2008, 26: 4124-4130.
Jaffe ES, NL H, Stein H, Vardiman JW: WHO Classification: Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues. 2001, Lyon: IARC
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW: WHO Classification: Pathology and Genetics of Tumors of Haematopoietic and Lymphoid Tissues. 2008, Lyon: IARC
Yoon S, Suh C, Lee D, Chi H, Park C, Jang S, Shin H, Park B, Huh J: Distribution of lymphoid neoplasms in the Republic of Korea: Analysis of 5318 cases according to the World Health Organization classification. Am J Hematol. 2010, 85: 760-764. 10.1002/ajh.21824.
Sukpanichnant S: Analysis of 1983 cases of malignant lymphoma in Thailand according to the World Health Organization classification. Hum Pathol. 2004, 35: 224-230. 10.1016/j.humpath.2003.10.007.
Aoki R, Karube K, Sugita Y, Nomura Y, Shimizu K, Kimura Y, Hashikawa K, Suefuji N, Kikuchi M, Ohshima K: Distribution of malignant lymphoma in Japan: analysis of 2260 cases, 2001-2006. Pathol Int. 2008, 58: 174-182. 10.1111/j.1440-1827.2007.02207.x.
Lee MY, Tan TD, Feng AC, Liu MC: Clinicopathological analysis of 598 malignant lymphomas in Taiwan: seven-year experience in a single institution. Am J Hematol. 2006, 81: 568-575. 10.1002/ajh.20649.
Chen W, Tsai W, Chao T: The clinicopathological analysis of 303 cases with malignant lymphoma classified according to the World Health Organization classification system in a single institute of Taiwan. Ann Hematol. 2010, 89: 553-562. 10.1007/s00277-009-0870-z.
Gross SA, Zhu X, Bao L, Ryder J, Le A, Chen Y, Wang XQ, Irons RD: A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China. Int J Hematol. 2008, 88: 165-173. 10.1007/s12185-008-0132-1.
Wang J, Young L, Win W, Taylor CR: Distribution and ZAP-70 Expression of WHO Lymphoma Categories in Shanxi, China: A Review of 447 Cases Using a Tissue Microarray Technique. Appl Immunohisto M M. 2005, 13: 323-332.
Morton LM, Wang SS, Devesa SS, Hartge P, Weisenburger DD, Linet MS: Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001. Blood. 2006, 107: 265-276. 10.1182/blood-2005-06-2508.
Armstrong A, Alexander F, Cartwright R, Angus B, Krajewski A, Wright D, Brown I, Lee F, Kane E, Jarrett R: Epstein-Barr virus and Hodgkin's disease: further evidence for the three disease hypothesis. Leukemia. 1998, 12: 1272-1276. 10.1038/sj.leu.2401097.
Nakatsuka S, Aozasa K: Epidemiology and pathologic features of Hodgkin lymphoma. Int J Hematol. 2006, 83: 391-397. 10.1532/IJH97.05184.
Au WY, Ma SY, Chim CS, Choy C, Loong F, Lie AK, Lam CC, Leung AY, Tse E, Yau CC, et al.: Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years. Ann Oncol. 2005, 16: 206-214. 10.1093/annonc/mdi037.
Xiao C, Su ZL, Wu QL, Hao HY, Fang JC, Xia ZJ, Guan ZC: Clinical and pathological reassessment of 493 cases of non-Hodgkin's lymphomas according to current WHO classification of lymphoid neoplasms. Zhong Hua Bing Li Xue Za Zhi. 2005, 34: 22-27.
Zhou LQ, Sun Y, Tan WY, Li T, Wang QL, Feng FY, Wang JW, Chu DT, Shi YK, Li YX, et al.: The clinical and pathological analysis for 1125 cases with non-Hodgkin's lymphoma. Ai Zheng Jin Zhan. 2006, 4: 391-397.
Yang SE, Li X, Zhao B, Jia CD, Zhang GQ: The Clinical and Pathological Analysis of 1,012 Cases of Non-Hodgkins Lymphoma. Zhong Guo Zhong Liu Lin Chuang. 2009, 36: 1412-1415.
Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, et al.: Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000, 403: 503-511. 10.1038/35000501.
Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, et al.: The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002, 346: 1937-1947. 10.1056/NEJMoa012914.
Hans C, Weisenburger D, Greiner T, Gascoyne R, Delabie J, Ott G, Muller-Hermelink H, Campo E, Braziel R, Jaffe E: Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004, 103: 275-282. 10.1182/blood-2003-05-1545.
Choi WWL, Weisenburger DD, Greiner TC, Piris MA, Banham AH, Delabie J, Braziel RM, Geng H, Iqbal J, Lenz G, et al.: A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy. Clin Cancer Res. 2009, 15: 5494-5502. 10.1158/1078-0432.CCR-09-0113.
Meyer PN, Fu K, Greiner TC, Smith LM, Delabie J, Gascoyne RD, Ott G, Rosenwald A, Braziel RM, Campo E, et al.: Immunohistochemical Methods for Predicting Cell of Origin and Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab. J Clin Oncol. 2011, 29: 200-207. 10.1200/JCO.2010.30.0368.
Chen Y, Han T, Iqbal J, Irons R, Chan W, Zhu X, Fu K: Diffuse Large B-Cell Lymphoma in Chinese Patients: Immunophenotypic and Cytogenetic Analyses of 124 Cases. Am J Clin Pathol. 2010, 133: 305-313. 10.1309/AJCP4H6ADGYDZMOA.
The Non-Hodgkin's Lymphoma Classification Project: A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. Blood. 1997, 89: 3909-3918.
Kwong YL, Anderson BO, Advani R, Kim WS, Levine AM, Lim ST: Management of T-cell and natural-killer-cell neoplasms in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncol. 2009, 10: 1093-1101. 10.1016/S1470-2045(09)70265-7.
Liang Q, Ye ZY, Su ZL, Lin HL, Shao CH, Lin SX, Rao HL, Mei KY, Zhao T, Liu YH, et al.: Clinicopathologic study of 963 cases of mature T-cell and natural killer/T-cell lymphoma with respect to 2008 WHO classification of lymphoid neoplasms. Zhong Hua Bing Li Xue Za Zhi. 2010, 39: 291-295.
Ko OB, Lee DH, Kim SW, Lee JS, Kim S, Huh J, Suh C: Clinicopathologic characteristics of T-cell non-Hodgkin's lymphoma: a single institution experience. Korean J Intern Med. 2009, 24: 128-134. 10.3904/kjim.2009.24.2.128.
Xu JX, Hoshida Y, Yang WI, Inohara H, Kubo T, Kim GE, Yoon JH, Kojya S, Bandoh N, Harabuchi Y, et al.: Life-style and environmental factors in the development of nasal NK/T-cell lymphoma: a case-control study in East Asia. Int J Cancer. 2006, 120: 406-410.
Aozasa K, Takakuwa T, Hongyo T, Yang W-I: Nasal NK/T-cell lymphoma: epidemiology and pathogenesis. Int J Hematol. 2008, 87: 110-117. 10.1007/s12185-008-0021-7.
Hochberg J, Waxman IM, Kelly KM, Morris E, Cairo MS: Adolescent non-Hodgkin lymphoma and Hodgkin lymphoma: state of the science. Br J Haematol. 2009, 144: 24-40. 10.1111/j.1365-2141.2008.07393.x.
The Non-Hodgkin's Lymphoma Classification Project: Effect of age on the characteristics and clinical behavior of non-Hodgkin's lymphoma patients. Ann Oncol. 1997, 8: 973-978. 10.1023/A:1008205619617.
Thieblemont C, Coiffier B: Lymphoma in older patients. J Clin Oncol. 2007, 25: 1916-1923. 10.1200/JCO.2006.10.5957.
Zucca E, Roggero E, Bertoni F, Cavalli F: Primary extranodal non-Hodgkin's lymphomas. Part 1: Gastrointestinal, cutaneous and genitourinary lymphomas. Ann Oncol. 1997, 8: 727-737. 10.1023/A:1008282818705.
Zucca E, Roggero E, Bertoni F, Conconi A, Cavalli F: Primary extranodal non-Hodgkin's lymphomas. Part 2: Head and neck, central nervous system and other less common sites. Ann Oncol. 1999, 10: 1023-1033. 10.1023/A:1008313229892.
Cavalli F, Stein H, Zucca E: Extranodal Lymphomas: Pathology and Management. 2008, London: Informa Healthcare
Krol ADG, le Cessie S, Snijder S, Kluin-Nelemans JC, Kluin PM, Noordijk EM: Primary extranodal non-Hodgkin's lymphoma (NHL): the impact of alternative definitions tested in the Comprehensive Cancer Centre West population-based NHL registry. Ann Oncol. 2003, 14: 131-139. 10.1093/annonc/mdg004.
Fujita A, Tomita N, Fujita H, Motohashi K, Hyo R, Yamazaki E, Hattori M, Fujisawa S, Kanamori H, Ogawa K, et al.: Features of primary extranodal lymphoma in Kanagawa, a human T-cell leukemia virus type 1 nonendemic area in Japan. Med Oncol. 2009, 26: 49-54. 10.1007/s12032-008-9080-0.
Lal A, Bhurgri Y, Vaziri I, Rizvi NB, Sadaf A, Sartajuddin S, Islam M, Kumar P, Adil S, Kakepoto GN, et al.: Extranodal non-Hodgkin's lymphomas--a retrospective review of clinico-pathologic features and outcomes in comparison with nodal non-Hodgkin's lymphomas. Asian Pac J Cancer Prev. 2008, 9: 453-458.