Submassive hepatic necrosis induced by dichloropropanol

Wiley - Tập 13 Số 3 - Trang 123-129 - 1993
Joji Haratake1, Akiko Furuta2, Toshio Iwasa3, Choei Wakasugi4, Kazuhiko Imazu5
1Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
2Department of Pathology & Oncology, School of Medicine, University of Occupational & Environmental Health, Japan
3Department of Internal Medicine, Health Examination Center, Kansai Rosai Hospital, Japan
4Department of Forensic Medicine, School of Medicine, Osaka University, Japan
5Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Tóm tắt

ABSTRACT— A hitherto undescribed industrial liver injury of fulminant form induced by dichloropropanol is reported. Two middle‐aged men developed severe hepatic injury just after cleaning a dichloropropanol tank at a plant producing dichloropropanol. They died from hepatic failure 4 and 11 days respectively, after carrying out the work. Liver specimens taken at autopsy from one of the cases showed submassive hepatic necrosis. This accident prompted us to undertake an experimental study in rats of intraperitoneal one‐shot injection of two isomeric substances of dichloropropanol, that is, 2,3‐dichloro‐l‐propanol (DCIP) and 1,3‐dichloro‐2‐propanol (DC2P). Saline was injected into the control rats. One, two, four, six, 24, 48, 72 h, and 1 week after the injection, rats in each group were sacrificed. Neither control nor DC IP‐injected rats showed significant biochemical or histopathological abnormalities. DC2P‐injected rats revealed elevations of transaminase from 6 h after the injections, and submassive necrosis of the liver was observed in many rats. It was concluded that the severe liver injuries in both the human cases and rats in our study were caused by DC2P.

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Tài liệu tham khảo

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Wiley

Tập 13 Số 3

123-129

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