Studies on changes in vitamin-E and fatty acids of neonatal serum
Tóm tắt
The fatty acid pattern, the total content of fatty acids and Vitamin-E of serum was assayed in newborns during the first weeks after birth. The data obtained were compared to the data of the mothers and to the newborn's diet. By relating the total content of polyunsaturated fatty acids to the vitamin-E content of the diet used for feeding newborns in Denmark, it was concluded that normally there was no risk of dietary induced vitamin-E deficiency and hereby no risk of peroxidative hemolysis. On the other hand, a low serum content of vitamin-E was encountered in newborns with a birth weight below 2500 gram. The serum content of vitamin-E was found to be normal in normal newborns with a birth weight above 2500 gram. The fatty acids of serum revealed pronounced changes during the neonatal period. Thus at birth the arachidonic acid content was higher, but the linoleic acid content lower than in adults. During the first two days of life, linoleic acid decreased and palmitic acid increased. In the following four days linoleic acid increased and palmitic acid decreased relatively. Stearic acid and arachidonic acid decreased and oleic acid increased in the whole period mentioned. The fatty acid findings mentioned were treated statistically by means of regression analysis and related to diet, and birth weight. Finally, the results were discussed on a basis of the literature available on the lipid metabolisn of the neonatal period.
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