Studies on antioxidants: Their carcinogenic and modifying effects on chemical carcinogenesis

Allen, 1976, Long-term antioxidant exposure effects on female primates, Archs envir. Hlth, 31, 47, 10.1080/00039896.1976.10667189

Ansari, 1985, Tissue distribution and pharmacokinetics of 3-t[methyl-14C]butyl-4-hydroxyanisole in rats, Drug Metab. Dispos., 13, 535

Armstrong, 1985, Metabolism of 3-tert-butyl-4-hydroxyanisole by rat liver microsomes, Cancer Res., 45, 1507

Benson, 1978, Elevation of hepatic glutathione S-transferase activities and protection against metabolites of benzo[a]pyrene by dietary antioxidants, Cancer Res., 38, 4486

Benson, 1979, Elevation of extrahepatic glutathione S-transferase and epoxide hydratase activities by 2(3)-tert-butyl-4-hydroxyanisole (BHA), Cancer Res., 39, 2971

Bonin, 1980, Mutagenicity testing of some approved food additives with the Salmonella/microsome assay, Fd Technol., Aust., 32, 608

Branen, 1975, Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene, J. Am. Oil Chem. Soc., 52, 59, 10.1007/BF02901825

Cha, 1982, Comparative effects of dietary administration of 2(3)-tert-butyl-4-hydroxyanisole and 3,5-di-tert-4-hydroxytoluene on several hepatic enzyme activities in mice and rats, Cancer Res., 42, 2609

Cha, 1978, Enhancement of liver microsome epoxide hydratase activity in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole, Cancer Res., 38, 4496

Cummings, 1983, Butylated hydroxyanisole-stimulated NADPH oxidase activity in rat liver microsomal fractions, J. biol. Chem., 258, 12315, 10.1016/S0021-9258(17)44176-7

Fukushima, 1983, Promoting effects of sodium l-ascorbate on two-stage urinary bladder carcinogenesis in rats, Cancer Res., 43, 4454

Fukushima, 1984, Promotion by ascorbic acid, sodium erythorbate and ethoxyquin of neoplastic lesions in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine, Cancer Lett., 23, 29, 10.1016/0304-3835(84)90058-2

Guarna, 1983, 2,2′-Dihydroxy-3,3′-di-t-butyl-5,5′-dimethoxydiphenyl, a new metabolite of 2-t-butyl-4-methoxyphenol in the rat, Drug Metab. Dispos., 11, 581

Hirose, 1985, Metabolism of orally administered BHA, 42

Hirose, 1986, Combined effects of butylated hydroxyanisole (BHA) and other antioxidants in induction of forestomach lesions in rats, Cancer Lett., 30, 169, 10.1016/0304-3835(86)90085-6

Hirose, 1986, Comparison of the effects of 13 phenolic compounds in induction of proliferative lesions of the forestomach and increase in the labelling indices of glandular stomach and urinary bladder epithelium of Syrian golden hamsters, Carcinogenesis, 7, 1285, 10.1093/carcin/7.8.1285

Hirose, 1986, Modification by antioxidants and p,p′-diamino-diphenylmethane of 7,12-dimethylbenz(a)anthracene-induced carcinogenesis of the mammary gland and ear duct in CD rats, Carcinogenesis, 7, 1155, 10.1093/carcin/7.7.1155

Hirose, 1986, Histological and autoradiographical studies on the forestomach of hamsters treated with 2-tert-butylated hydroxyanisole, 3-tert-butylated hydroxyanisole, crude butylated hydroxyanisole or butylated hydroxytoluene, J. natn. Cancer Inst., 76, 143

Hodge, 1964, Chronic feeding studies of butylated hydroxyanisole in dogs, Toxic. appl. Pharmac., 6, 512, 10.1016/0041-008X(64)90083-3

Hodge, 1966, Tests on mice for evaluating carcinogenicity, Toxic. appl. Pharmac., 9, 583, 10.1016/0041-008X(66)90019-6

Imaida, 1984, Promoting activities of butylated hydroxyanisole, butylated hydroxytoluene and sodium l-ascorbate on forestomach and urinary bladder carcinogenesis initiated with methylnitrosourea in F344 male rats, Gann, 75, 769

Imaida, 1983, Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of gamma-glutamyl transpeptidase-positive foci development in the liver of rats, Carcinogenesis, 4, 895, 10.1093/carcin/4.7.895

Ingold, 1961, Inhibition of autoxidation of organic substances in the liquid phase, Chemy Rev., 61, 563, 10.1021/cr60214a002

International Program on Chemical Safety, 1983, Toxicological evaluation of certain food additives and food contaminants, WHO Food Additives Series No. 18

Ishidate, 1984, Primary mutagenicity screening of food additives currently used in Japan, Fd Chem. Toxic., 22, 623, 10.1016/0278-6915(84)90271-0

Ito, 1983, Carcinogenicity of butylated hydroxyanisole in F344 rats, J. natn. Cancer Inst., 70, 343

Ito, 1986, Dose-response study of forestomach carcinogenesis in F344 rats induced by butylated hydroxyanisole, J. natn. Cancer Inst.

Ito, 1984, Induction of forestomach hyperplasia by crude butylated hydroxyanisole, a mixture of 3-tert- and 2-tert isomers in Syrian golden hamsters is due to 3-tert-butylated hydroxyanisole, Gann, 75, 471

Iverson, 1985, An 85-day study of butylated hydroxyanisole in the cynomolgus monkey, Cancer Lett., 26, 43, 10.1016/0304-3835(85)90171-5

Kelleher, 1976, Modification of paracetamol toxicity by antioxidants, Biochem. Soc. Trans., 4, 292, 10.1042/bst0040292

King, 1981, Comparison of the effect of butylated hydroxytoluene on N-nitrosomethylurea and 7,12-dimethylbenz[a]anthracene-induced mammary tumours, Cancer Lett., 14, 219, 10.1016/0304-3835(81)90147-6

Kitahara, 1984, Changes in molecular forms of rat hepatic glutathione S-transferase during chemical hepatocarcinogenesis, Cancer Res., 44, 2698

Kohn, 1971, Effect of antioxidants of life-span of C57BL mice, J. Gerontol., 26, 378, 10.1093/geronj/26.3.378

Lam, 1977, Effects of butylated hydroxyanisole on the metabolism of benzo-[a]pyrene by mouse liver microsomes, J. natn. Cancer Inst., 58, 413, 10.1093/jnci/58.2.413

McCormick, 1984, Inhibition of 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinogenesis by concomitant or post-carcinogen antioxidant exposure, Cancer Res., 44, 2858

Macura, 1984, Dose dependent reduction of N-2-fluorenylacetamide-induced liver cancer and enhancement of bladder cancer in rats by butylated hydroxytoluene, Cancer Res., 44, 1604

Masui, 1985, Species differences with regard to sequential changes induced by butylated hydroxyanisole in the forestomach of rats, mice and hamsters, 48

Rahimtula, 1983, In vitro metabolism of 3-t-butyl-4-hydroxyanisole and its irreversible binding to proteins, Chemico-Biol. Interactions, 45, 125, 10.1016/0009-2797(83)90048-0

Sato, 1984, The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis, Gann, 75, 199

Satoh, 1985, Purification, induction, and distribution of placental glutathione transferase: A new marker enzyme for preneoplastic cells in the rat chemical carcinogenesis, 82, 3964

Shirai, 1984, Effects of butylated hydroxyanisole, butylated hydroxytoluene, and NaCl on gastric carcinogenesis initiated with N-methyl-N′-nitro-N-nitrosoguanidine in F344 rats, J. natn. Cancer Inst., 72, 1189

Shirai, 1985, Modification by five antioxidants of 1,2-dimethylhydrazine-initiated colon carcinogenesis in F344 rats, Carcinogenesis, 6, 637, 10.1093/carcin/6.4.637

Tatematsu, 1985, Relative merits of immunohistochemical demonstration of placental, A, B, and C forms of glutathione S-transferase and histochemical demonstration of gamma-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats, Carcinogenesis, 6, 1621, 10.1093/carcin/6.11.1621

Thamavit, 1985, Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase, Cancer Lett., 27, 295, 10.1016/0304-3835(85)90187-9

Tsuda, 1984, Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine, Carcinogenesis, 5, 525, 10.1093/carcin/5.4.525

Wattenberg, 1972, Inhibition of carcinogenic and toxic effects of polycyclic hydrocarbons by phenolic antioxidants and ethoxyquin, J. natn. Cancer Inst., 48, 1425

Wattenberg, 1973, Inhibition of chemical carcinogen-induced pulmonary neoplasia by butylated hydroxyanisole, J. natn. Cancer Inst., 50, 1541, 10.1093/jnci/50.6.1541

Wattenberg, 1977, Inhibitors of colon carcinogenesis, Cancer, N.Y., 40, 2432, 10.1002/1097-0142(197711)40:5+<2432::AID-CNCR2820400907>3.0.CO;2-8

Wattenberg, 1978, Inhibition of chemical carcinogenesis, J. natn. Cancer Inst., 60, 11, 10.1093/jnci/60.1.11

Wattenberg, 1978, Inhibitors of chemical carcinogenesis, Adv. Cancer Res., 26, 197, 10.1016/S0065-230X(08)60088-3

Wattenberg, 1979, Inhibitory effects of butylated hydroxyanisole on methylazoxymethanol acetate-induced neoplasia of the large intestine and on nicotinamide adenine dinucleotide-dependent alcohol dehydrogenase activity in mice, J. natn. Cancer Inst., 63, 219

Wattenberg, 1979, Neoplastic effects or oral administration of (±)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene and their inhibition by butylated hydroxyanisole, J. natn. Cancer Inst., 62, 1103

Weisburger, 1977, Inhibitory effect of butylated hydroxytoluene (BHT) on intestinal carcinogenesis in rats by azoxymethane, Fd Cosmet. Toxicol., 15, 139, 10.1016/S0015-6264(77)80320-9

Wilder, 1960, Effect of feeding butylated hydroxyanisole to dogs, J. agric. Fd Chem., 8, 504, 10.1021/jf60112a025

Witschi, 1981, Enhancement of tumor formation in mouse lung by dietary butylated hydroxytoluene, Toxicology, 21, 95, 10.1016/0300-483X(81)90120-7