Studies on Aspergillus Fumigatus; Toxin Production Ry Different Strains and Serological Comparison of the Strains
Tóm tắt
Saline extracts of mycelial material from 14 different strains of Aspergillus fumigatus showed haemolytic and toxic activities. These activities were present in filtrates obtained from mycelial material incubated at 20°C for 6, 15 and 30 days and at 37°C for 6 days. The haemolysin and toxin titers decreased with an increase in incubation time and at higher incubation temperatures. The haemolytic and toxic activities could be inactivated by heating the filtrates at 70°C for 10 min. The results of serological tests demonstrated immunological uniformity for the haemolytic and toxic factors.
Tài liệu tham khảo
Batelli, C.: Sopra alcuni casi di aspergillosi aviare in Eritrea. Cit. Vet. Bull. (Weybridge) 1946, 16, 97.
Bodin, E. & L. Gautier: Note sur une toxine produite par l’Aspergillus fumigatus. Ann. Inst. Pasteur 1906, 20, 209–224.
Bodin, E. & C. Lenormande: Recherches sur les poisons produits par l’Aspergillus fumigatus. Ann. Inst. Pasteur 1912, 26, 371–380.
Carll, W. T., J. Forgacs, A. S. Herring & B. G. Mahlandt: Toxicity of Aspergillus fumigatus substrates to animals. Vet. Med. 1955, 50, 210–212.
Ceni, C. & C. Besta: Über die Toxine von Aspergillus fumigatus und A. flavescens und deren Beziehungen zur Pellagra. Zbl. allg. Path. path. Anat. 1902, 13, 930–941.
Forgacs, J. & W. T. Carll: Mycotoxicoses. Advanc vet. Sci. 1962, 7, 273–381.
Fukui, M. & J. Yasuda: Serological studies on Aspergillus fumigatus. Mycopathologia 1961, 14, 39–54.
Henrici, A. T.: An endotoxin from Aspergillus fumigatus. J. Immunol. 1939, 36, 319–338.
Lucet, A.: Étude experimentale et clinique sur l’Aspergillus fumigatus. Rec. Méd. vét. 1898, 575–614.
Martins, C.: Études expérimentales sur l’Aspergillus fumigatus. C. R. Soc. Biol. (Paris) 1929, 100, 525–526.
Pepys, J., R. W. Riddel, K. M. Citron, Y. M. Clayton & E. J. Short: Clinical and immunologic significance of Aspergillus fumigatus in the sputum. Amer. Rev. resp. Dis. 1959, 80, 167–180.
Rau, E. M., E. B. Tilden & V. L. Koenig: Partial purification and characterization of the endotoxin from Aspergillus fumigatus. Mycopathologia 1961, 14, 347–358.
Salvin, S. B.: Endotoxin in pathogenic fungi. J. Immunol. 1952, 69, 89–99.
Seeliger, H. P. R.: Zur Anwendungsmöglichkeit der Präzipitation im Agar-Gel bei der O-Antigenanalyse von Bakterien und Pilzen. Z. Hyg. 1955, 141, 110–121.
Seeliger, H. P. R.: Mykologische Serodiagnostik. Beitr. Hyg. Epidem. 1958, Hft 11, 114.
Shurawléw, W. W.: Aspergillose der Schweine. Veterinarija. 1962, 9, 33–34. Git. Prakt. Tierarzt 1963, 2, 59–60.
Stanley, N. F.: Biological properties of polysaccharide and lipoid fractions from a pathogenic strain of Aspergillus fumigatus. Aust. J. exp. Biol. med. Sci. 1950, 28, 99–108.
Tilden, E. B., E. H. Hatton, S. Freeman & W. M. Williamson: Studies of Aspergilli from captive wild birds. Bact. Proc. 1957, 57, 144.
Tilden, E. B., E. H. Hatton, S. Freeman, W. M. Williamson & V. L. Koenig: Preparation and properties of the endotoxins of Aspergillus fumigatus and Aspergillus flavus. Mycopathologia 1961, 14, 325–346.