Nghiên cứu và Tầm nhìn của Protein Kinase C

American Association for the Advancement of Science (AAAS) - Tập 233 Số 4761 - Trang 305-312 - 1986
Yasutomi Nishizuka1
1Department of Biochemistry, Kobe University School of Medicinc, Kobc, Japan.

Tóm tắt

Protein kinase C, một enzyme được kích hoạt bởi quá trình phân giải inositol phospholipid qua trung gian thụ thể, truyền tải thông tin dưới dạng nhiều tín hiệu ngoại bào qua màng để điều chỉnh nhiều quá trình phụ thuộc Ca 2+ . Ở giai đoạn sớm của các phản ứng tế bào, enzyme này dường như có tác động kép, cung cấp cả điều khiển phản hồi tích cực lẫn tiêu cực đối với nhiều bước trong chính con đường tín hiệu của nó và các con đường tín hiệu khác, chẳng hạn như các thụ thể liên kết với quá trình phân giải inositol phospholipid và của một số yếu tố tăng trưởng. Trong các hệ thống sinh học, một tín hiệu tích cực thường được theo sau bởi việc điều tiết phản hồi tiêu cực ngay lập tức. Vai trò mới lạ của hệ thống protein kinase này dường như cung cấp cơ sở hợp lý để làm rõ cơ chế hóa sinh của truyền tải tín hiệu, và bổ sung một chiều kích yếu tố cần thiết cho sự hiểu biết của chúng ta về giao tiếp tế bào với tế bào.

Từ khóa

#Protein Kinase C #enzyme #phân giải inositol phospholipid #truyền tải tín hiệu #phản hồi tích cực #phản hồi tiêu cực #giao tiếp tế bào

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