Structure of unliganded HSV gD reveals a mechanism for receptor-mediated activation of virus entry

EMBO Journal - Tập 24 Số 23 - Trang 4144-4153 - 2005
Claude Krummenacher1, Vinit M. Supekar2, J. Charles Whitbeck3, Eric Lazear1, Sarah A. Connolly1, Roselyn J. Eisenberg3, Gary H. Cohen1, Don C. Wiley4, Andrea Carfı́2
1Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
2Biochemistry Department, IRBM P Angeletti; Pomezia Rome Italy
3Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA. USA
4Children's Hospital Laboratory of Molecular Medicine; Boston MA USA

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Campadelli-Fiume, 2000, The novel receptors that mediate the entry of herpes simplex viruses and animal alphaherpesviruses into cells, Rev Med Virol, 10, 305, 10.1002/1099-1654(200009/10)10:5<305::AID-RMV286>3.0.CO;2-T

Carfi, 2002, Crystallization and preliminary diffraction studies of the ectodomain of the envelope glycoprotein D from herpes simplex virus 1 alone and in complex with the ectodomain of the human receptor HveA, Acta Crystallogr D, 58, 836, 10.1107/S0907444902001270

Carfi, 2001, Herpes simplex virus glycoprotein D bound to the human receptor HveA, Mol Cell, 8, 169, 10.1016/S1097-2765(01)00298-2

1994 The CCP4 suite: programs for protein crystallography Acta Crystallogr D 50 760 763

Chiang, 1994, Identification of functional regions of herpes simplex virus glycoprotein gD by using linker-insertion mutagenesis, J Virol, 68, 2529, 10.1128/JVI.68.4.2529-2543.1994

Cocchi, 2004, The soluble ectodomain of herpes simplex virus gD contains a membrane-proximal pro-fusion domain and suffices to mediate virus entry, Proc Natl Acad Sci USA, 101, 7445, 10.1073/pnas.0401883101

Cohen, 1986, Localization of discontinuous epitopes of herpes simplex virus glycoprotein D: use of a nondenaturing (‘native’ gel) system of polyacrylamide gel electrophoresis coupled with Western blotting, J Virol, 60, 157, 10.1128/JVI.60.1.157-166.1986

Connolly, 2005, Potential nectin-1 binding site on herpes simplex virus glycoprotein D, J Virol, 79, 1282, 10.1128/JVI.79.2.1282-1295.2005

Connolly, 2003, Structure-based mutagenesis of herpes simplex virus glycoprotein D defines three critical regions at the gD/HveA interface, J Virol, 77, 8127, 10.1128/JVI.77.14.8127-8140.2003

Connolly, 2002, Structure-based analysis of the herpes simplex virus glycoprotein D binding site present on herpesvirus entry mediator HveA (HVEM), J Virol, 76, 10894, 10.1128/JVI.76.21.10894-10904.2002

Dean, 1994, Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity, Virology, 199, 67, 10.1006/viro.1994.1098

Fusco, 2005, The pro-fusion domain of herpes simplex virus glycoprotein D (gD) interacts with the gD N terminus and is displaced by soluble forms of viral receptors, Proc Natl Acad Sci USA, 102, 9323, 10.1073/pnas.0503907102

Haan, 2000, Epstein-Barr virus entry utilizing HLA-DP or HLA-DQ as a coreceptor, J Virol, 74, 2451, 10.1128/JVI.74.5.2451-2454.2000

Handler, 1996, Crosslinking of glycoprotein oligomers during herpes simplex virus type 1 entry, J Virol, 70, 6076, 10.1128/JVI.70.9.6076-6082.1996

Hazes, 1988, Model building of disulfide bonds in proteins with known three-dimensional structure, Prot Eng, 2, 119, 10.1093/protein/2.2.119

Jogger, 2004, Effects of linker-insertion mutations in herpes simplex virus 1 gD on glycoprotein-induced fusion with cells expressing HVEM or nectin-1, Virology, 318, 318, 10.1016/j.virol.2003.10.004

Jones, 1991, Improved methods for building protein models in electron density maps and the location of errors in these models, Acta Crystallogr A, 47, 110, 10.1107/S0108767390010224

Krummenacher, 1998, Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry, J Virol, 72, 7064, 10.1128/JVI.72.9.7064-7074.1998

Krummenacher, 1999, The first immunoglobulin-like domain of HveC is sufficient to bind herpes simplex virus gD with full affinity while the third domain is involved in oligomerization of HveC, J Virol, 73, 8127, 10.1128/JVI.73.10.8127-8137.1999

Li, 1997, Epstein-Barr virus uses HLA class II as a cofactor for infection of B lymphocytes, J Virol, 71, 4657, 10.1128/JVI.71.6.4657-4662.1997

Ligas, 1988, A herpes simplex virus mutant in which glycoprotein D sequences are replaced by β-galactosidase sequences binds to but is unable to penetrate into cells, J Virol, 62, 1486, 10.1128/JVI.62.5.1486-1494.1988

Lo Conte, 1999, The atomic structure of protein-protein recognition sites, J Mol Biol, 285, 2177, 10.1006/jmbi.1998.2439

Manoj, 2004, Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism, Proc Natl Acad Sci USA, 101, 12414, 10.1073/pnas.0404211101

Milne, 2003, Function of herpes simplex virus type 1 gD mutants with different receptor-binding affinities in virus entry and fusion, J Virol, 77, 8962, 10.1128/JVI.77.16.8962-8972.2003

Minson, 1986, An analysis of the biological properties of monoclonal antibodies against glycoprotein D of herpes simplex virus and identification of amino acid substitutions that confer resistance to neutralization, J Gen Virol, 67, 1001, 10.1099/0022-1317-67-6-1001

Mullen, 2002, Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1, Mol Cell, 9, 375, 10.1016/S1097-2765(02)00465-3

Nicola, 1997, Antigenic structure of soluble herpes simplex virus glycoprotein D correlates with inhibition of HSV infection, J Virol, 71, 2940, 10.1128/JVI.71.4.2940-2946.1997

Nicola, 1998, Monoclonal antibodies to distinct sites on the herpes simplex virus (HSV) glycoprotein D block HSV binding to HVEM, J Virol, 72, 3595, 10.1128/JVI.72.5.3595-3601.1998

Perrakis, 1999, Automated protein model building combined with iterative structure refinement, Nat Struct Biol, 6, 458, 10.1038/8263

Rux, 1998, Functional region IV of glycoprotein D from herpes simplex virus modulates glycoprotein binding to the herpes virus entry mediator, J Virol, 72, 7091, 10.1128/JVI.72.9.7091-7098.1998

Sisk, 1994, High-level expression and purification of secreted forms of herpes simplex virus type 1 glycoprotein gD synthesized by baculovirus-infected insect cells, J Virol, 68, 766, 10.1128/JVI.68.2.766-775.1994

Spear, 2004, Herpes simplex virus: receptors and ligands for cell entry, Cell Microbiol, 6, 401, 10.1111/j.1462-5822.2004.00389.x

Spear, 2000, Three classes of cell surface receptors for alphaherpesvirus entry, Virology, 275, 1, 10.1006/viro.2000.0529

Spear, 2003, Herpesvirus entry: an update, J Virol Methods, 77, 10179, 10.1128/JVI.77.19.10179-10185.2003

Whitbeck, 1999, The major neutralizing antigenic site on herpes simplex virus glycoprotein D overlaps a receptor-binding domain, J Virol, 73, 9879, 10.1128/JVI.73.12.9879-9890.1999

Whitbeck, 1997, Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the TNFR superfamily and a mediator of HSV entry, J Virol, 71, 6083, 10.1128/JVI.71.8.6083-6093.1997

Whitley, 2001, Herpes simplex viruses, Fields Virology, 2461

Willis, 1998a, Expression and purification of secreted forms of HSV glycoproteins from baculovirus-infected insect cells, Methods in Molecular Medicine, 131

Willis, 1998b, Examination of the kinetics of herpes simplex virus glycoprotein D binding to the herpesvirus entry mediator, using surface plasmon resonance, J Virol, 72, 5937, 10.1128/JVI.72.7.5937-5947.1998

Wyatt, 1998, The antigenic structure of the HIV gp120 envelope glycoprotein, Nature, 393, 705, 10.1038/31514

Yoon, 2003, Mutations in the N termini of herpes simplex virus type 1 and 2 gDs alter functional interactions with the entry/fusion receptors HVEM, nectin-2, and 3-O-sulfated heparan sulfate but not with nectin-1, J Virol, 77, 9221, 10.1128/JVI.77.17.9221-9231.2003

Zago, 2004, Use of herpes simplex virus and pseudorabies virus chimeric glycoprotein D molecules to identify regions critical for membrane fusion, Proc Natl Acad Sci USA, 101, 17498, 10.1073/pnas.0408186101

Zhou, 2003, The domains of glycoprotein D required to block apoptosis induced by herpes simplex virus 1 are largely distinct from those involved in cell-cell fusion and binding to nectin1, J Virol, 77, 3759, 10.1128/JVI.77.6.3759-3767.2003