Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

Donghyun Kang1,2, Jungkwon Shin1,2, Yong-Sik Cho1,2, Hyeon Seop Kim1,2, Young Gu1,2, Haedong Kim1,2, Kwon Tae You1,2, Moon Jong Chang3, Chong Bum Chang3, Seung‐Baik Kang3, Jong‐Seo Kim1,2, V. Narry Kim1,2, Jin‐Hong Kim1,2,4
1Center for RNA Research, Institute for Basic Science, 08826 Seoul, South Korea.
2Department of Biological Sciences, College of Natural Sciences, Seoul National University, 08826 Seoul, South Korea.
3Department of Orthopedic Surgery, Seoul National University College of Medicine, Boramae Hospital, 07061 Seoul, South Korea.
4Interdisciplinary Program in Bioinformatics, Seoul National University, 08826 Seoul, South Korea.

Tóm tắt

Senescence-induced miR-204 alters the proteoglycan biosynthesis pathway and disrupts matrix homeostasis in osteoarthritic cartilage.

Từ khóa


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