Phản ứng saccade kích thích từ vỏ não trán trung gian của khỉ rhesus sau khi cắt bỏ lĩnh vực mắt trán và colliculus trên

Springer Science and Business Media LLC - Tập 98 - Trang 179-190 - 1994
Edward J. Tehovnik1, Kyoungmin Lee1, Peter H. Schiller1
1Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, USA

Tóm tắt

Nghiên cứu này đã xem xét liệu các tín hiệu cho việc tạo ra chuyển động mắt từ vỏ não trán trung gian (DMFC) có đến được các trung tâm vận động mắt ở thân não thông qua các lĩnh vực mắt trán (FEF) hay thông qua các colliculus trên (SC) hay không. DMFC đã được kích thích khi các con khỉ được nghiên cứu còn nguyên vẹn và sau khi cắt bỏ một FEF hoặc một SC. Sau khi có tổn thương ở FEF hoặc SC, thứ tự topographic của DMFC hầu như được bảo tồn. Sau mỗi tổn thương, kích thích các vị trí DMFC phía trước vẫn gây ra các phản ứng saccade mà kết thúc ở không gian đối bên, và kích thích các vị trí DMFC phía sau vẫn gây ra các phản ứng saccade mà kết thúc ở không gian trung tâm. Xác suất gây ra phản ứng saccade giảm và độ trễ để gây ra phản ứng saccade tăng lên khi việc định vị gần đến vùng kết thúc (một vùng hạn chế trong không gian craniotopic) cả trước và sau khi có tổn thương. Cắt bỏ SC, nhưng không phải FEF, đã loại bỏ sự ức chế saccade đối với các mục tiêu thị giác xảy ra khi DMFC được kích thích ở con vật nguyên vẹn. Các phát hiện cho thấy rằng có thêm các kênh khác ngoài những kênh đi qua FEF và SC được DMFC sử dụng để tiếp cận bộ điều khiển saccade trong thân não.

Từ khóa


Tài liệu tham khảo

Albano JE, Wurtz RH (1982) Deficits in eye position following ablation of monkey superior colliculus, pretectum, and posterior-medial thalamus. J Neurophysiol 48:318–337. Batton RR III, Jayaraman A, Ruggiero D, Carpenter BM (1978) Fastigial efferent projections in the monkey: an autoradiographic study. J Comp Neurol 174:281–306. Bon L, Lucchetti C (1992) The dorsomedial frontal cortex of the macaque monkey: fixation and saccade-related activity. Exp Brain Res 89:571–580. Bruce CJ, Goldberg ME, Bushnell MC, Stanton GB (1985) Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. J Neurophysiol 54:714–734. Buttner-Ennever JA, Henn V (1976) An autoradiographic study of the pathways from the pontine reticular formation involved in horizontal eye movement. Brain Res 108:155–164. Cohen B, Buttner-Ennerver JA, Waitzman D, Bender MB (1981) Anatomical connections of a portion of the dorsolateral mesencephalic reticular formation associated with horizontal saccadic eye movements. Soc Neurosci Abstr 7:132. Cohen B, Matsuo V, Fradin J, Raphan T (1985) Horizontal saccades induced by stimulation of the central mesencephalic reticular formation. Exp Brain Res 57:605–616. Cohen B, Waitzman DM, Buttner-Ennever JA, Matsuo V (1986) Horizontal saccades and the central mesencephalic reticular formation. Prog Brain Res 64:243–256. Crandall WF, Keller EL (1985) Visual and oculomotor signals in nucleus reticularis tegmenti pontis in alert monkey. J Neurophysiol 54:1326–1345. Edwards SB (1975) Autoradiographic studies of the projections of the midbrain reticular formation: descending projections of nucleus cuneiformis. J Comp Neurol 161:341–358. Hikosaka O, Sakamoto M, Usui S (1989) Functional properties of monkey caudate neurons. I. Activities related to saccadic eye movements. J Neurophysiol 61:780–798. Huerta MF, Kaas JH (1990) Supplementary eye field as defined by intracortical microstimulation: connections in macaques. J Comp Neurol 293:299–330. Johnson R (1976) Elementary statistics. Duxbury Press, North Scituate Mass. Judge SJ, Richmond BJ, Chu FC (1980) Implantation of magnetic search coils for measurement of eye position: an improved method. Vision Res 20:535–538. Kase M, Miller DC, Noda H (1980) Discharge of purkinje cells and mossy fibres in the cerebellar vermis of the monkey during saccadic eye movements and fixation. J Physiol (Lond) 300:539–555. Keating EG, Gooley SG (1988) Disconnection of parietal and occipital access to the saccadic oculomotor system. Exp Brain Res 70:385–398. Keating EG, Gooley SG, Pratt S, Kelsey J (1983) Removing the superior colliculus silences eye movements normally evoked from stimulation of the parietal and occipital eye fields. Brain Res 269:145–148. Lafleur J, Lean J, Poirier LJ (1974) Physiopathology of the cerebellum in the monkey. 1. Origin of cerebellar afferent nervous fibers from the spinal cord and brainstem. J Neurol Sci 22:471–490. Leichnetz GR (1981) The prefrontal cortico-oculomotor trajectories in the monkey. J Neurol Sci 49:387–396. Lee C, Rohrer WH, Sparks DL (1988) Population coding of saccadic eye movements by neurons in the superior colliculus. Science 332:357–360. Lee K-M, Tehovnik EJ (1991) Eye-position dependency of units in the dorsomedial frontal cortex. Soc Neurosci Abstr 17:546. Mann SE, Thau R, Schiller PH (1988) Conditional task-related responses in monkey dorsomedial frontal cortex. Exp Brain Res 69:460–468. Mays LE, Sparks LD (1980) Saccades are spatially, not retinocentrically coded. Science 208:1163–1165. McElligott JG, Keller EL (1984) Cerebellar vermis involvement in monkey saccadic eye movements: microstimulation. Exp Neurol 86:543–558. Munoz DP, Wurtz RH (1992) Role of the rostral superior colliculus in active visual fixation and execution of express saccades. J Neurophysiol 67:1000–1002. Noda H, Suzuki DA (1979) The role of the flocculus of the monkey in fixation and smooth pursuit eye movements. J Physiol (Lond) 294:335–348. Parthasarathy HB, Schall JD, Graybiel AM (1992) Distributed but convergent ordering of corticostriatal projections: analysis of the frontal eye field and the supplementary eye field in the macaque monkey. J Neurosci 12:4468–4488. Precht W (1977) The functional synaptology of brain stem oculomotor pathways. In: Berthoz A, Baker R (eds) Control of gaze by brain stem neurons. Elsevier/North-Holland, New York, pp 131–141. Raybourn MS, Keller EL (1977) Colliculoreticular organization in primate oculomotor system. J Neurophysiol 40:861–878. Ritchie L (1976) Effects of cerebellar lesions on saccadic eye movements. J Neurophysiol 39:1246–1256. Robinson DA (1970) Oculomotor unit behavior in the monkey. J Neurophysiol 33:393–404. Robinson DA (1972) Eye movements evoked by collicular stimulation in the alert monkey. Vision Res 12:1795–1808. Robinson DA, Fuchs AF (1969) Eye movements evoked by stimulation of frontal eye fields. J Neurophysiol 32:637–648. Rohrer WH, White JM, Sparks DL (1987) Saccade-related burst cells in the superior colliculus: relationship of activity with saccadic velocity. Soc Neurosci Abstr 13:1092. Ron S, Robinson DA (1973) Eye movements evoked by cerebellar stimulation in the alert monkey. J Neurophysiol 36:1004–1022. Schall JD, Mann SE, Schiller PH (1987) Investigation of the roles of dorsomedial and ventromedial premotor regions and the frontal eye fields in visually guided movements. Soc Neurosci Abstr 13:1095. Schall JD, Morel A, Kaas JH (1993) Topography of supplementary eye field afferents to frontal eye field in macaque: implications for mapping between saccade coordinate systems. Vis Neurosci 10:385–393. Schiller PH (1977) The effect of superior colliculus ablation on saccades elicited by cortical stimulation. Brain Res 122:154–156. Schiller PH, Sandeil JH (1983) Interactions between visually and electrically elicited saccades before and after superior colliculus and frontal eye field ablations in the rhesus monkey. Exp Brain Res 49:381–392. Schiller PH, Sandell JH, Maunsell JHR (1987) The effect of frontal eye field and superior colliculus lesions on saccadic latencies in the rhesus monkey. J Neurophysiol 57:1033–1049. Schiller PH, Stryker M (1972) Single-unit recording and stimulation in superior colliculus of the alert rhesus monkey. J Neurophysiol 42:1124–1133. Schiller PH, True SD, Conway JL (1980) Deficits in eye movements following frontal eye-field and superior colliculus ablations. J Neurophysiol 44:1175–1189. Schlag J, Schlag-Rey M (1987) Evidence for a supplementary eye field. J Neurophysiol 57:179–200. Schlag J, Schlag M, Pigarev I (1992) Supplementary eye field: influence of eye position on neural signals of fixation. Exp Brain Res 90:302–306. Tehovnik EJ, Lee K-M (1993) The dorsomedial frontal cortex of the rhesus monkey. Topographic representation of saccades evoked by electrical stimulation. Exp Brain Res 96:430–442. Tehovnik EJ, Lee K-M, Schiller PH (1991) Effect of frontal eye field or superior colliculus lesions on stimulation-evoked saccades elicited from the primate dorsomedial frontal cortex. Soc Neurosci Abstr 16:458. Waitzman DM, Cohen B (1979) Unit activity in the mesencephalic reticular formation (MRF) accociated with saccades and positions of fixation during a visual attention task. Soc Neurosci Abstr 5:389. Zee DS, Yamazaki A, Butler PH, Gucer G (1981) Effects of ablation of flocculus and paraflocculus on eye movements in primate. J Neurophysiol 46:878–899.