Stevia rebaudiana Bertoni: An alternative Sugar Replacer and Its Application in Food Industry

Pól J, Hohnová B, Hyötyläinen T (2007) Characterisation of Stevia Rebaudiana by comprehensive two-dimensional liquid chromatography time-of-flight mass spectrometry. J Chromatogr 1150:85–92 Fukushima S, Arai M, Nakanowatari J, Hibino T, Okuda M, Ito N (1983) Differences in susceptibility to sodium saccharin among various strains of rats and other animal species. Gann 74:8–20 Whysner J, Williams GM (1996) Saccharin mechanistic data and risk assessment: urine composition, enhanced cell proliferation, and tumor promotion. Pharmacol Ther 71:225–252 Dybing E (2002) Development and implementation of the IPCS conceptual framework for evaluating mode of action of chemical carcinogens. Toxicol 181:121–125 Authority EFS (2011) Statement of EFSA on the scientific evaluation of two studies related to the safety of artificial sweeteners. EFSA Journal 9: 16 www.efsa.europa.eu/efsajournal Allam A, Nassar A, Besheit S (2001) Nitrogen fertilizer requirements of Stevia rebaudiana bertoni, under Egyptian conditions. Egypt J Agric Res 79:1005–1018 Gasmalla MAA, Yang R, Amadou I, Hua X (2014) Nutritional composition of Stevia rebaudiana Bertoni leaf: effect of drying method. Trop J Pharm Res 13:61–65 Abou-Arab AE, Abou-Arab AA, Abu-Salem MF (2010) Physico-chemical assessment of natural sweeteners steviosides produced from Stevia rebaudiana Bertoni plant. Afr J Food Sci 4:269–281 Hansen H-J (2010) Future use of steviol glycosides: results of a survey in the German beverage industry. J Verbr Lebensm 5:237–239 Kienle U (2007) Stevia rebaudiana. Natural sweetness in the bureaucratic jungle. J Culin 5:59–69 Kienle U (2010) A natural fabric makes career. J Verbr Lebensm 5:199–203 Kroyer G (2010) Stevioside and Stevia-sweetener in food: application, stability and interaction with food ingredients. J Verbr Lebensm 5:225–229 Herranz-Lopez M, Barrajon-Catalan E, Beltran-Debon R, Joven J, Micol V (2010) Stevia is a source for alternative sweeteners: potential medicinal effects. Agro Food Ind Hi Tech 21:38–42 Crammer B, Ikan R (1986) Sweet glycosides from the stevia plant. Chem Br 22:915 Kohda H, Kasai R, Yamasaki K, Murakami K, Tanaka O (1976) New sweet diterpene glucosides from Stevia rebaudiana. Phytochemistry 15:981–983 Wölwer-Rieck U (2012) The leaves of Stevia rebaudiana (Bertoni), their constituents and the analyses thereof: a review. J Agric Food Chem 60:886–895 Carakostas M, Curry L, Boileau A, Brusick D (2008) Overview: the history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages. Food Chem Toxicol 46:S1–S10 Schiffman SS, Sattely-Miller EA, Graham BG, Bennett JL, Booth BJ, Desai N, Bishay I (2000) Effect of temperature, pH, and ions on sweet taste. Physiol Behav 68:469–481 Kovylyaeva G, Bakaleinik G, Strobykina IY, Gubskaya V, Sharipova R, Al’Fonsov V, Kataev V, Tolstikov A (2007) Glycosides from Stevia rebaudiana. Chem Nat Compd 43:81–85 Joint F WHO Expert Committee on Food Additives (JECFA). Steviol glycosides. In: Compendium of food additive specifications, 73th meeting, FAO JECFA Monographs, vol 10, pp 17–22 Kienle U (2010) What is Stevia would you like? Cultivation and production prospects world wide. J Verbr Lebensm 5:241–250 Purkayastha S, Markosyan A, Malsagov M (2012) Process for manufacturing a sweetener and use thereof. In: Google Patents No. 8,334,006 Magomet M, Tomov T, Somann T, Abelyan VH (2011) Process for manufacturing a sweetener and use thereof. In: Google Patents No. 7,862,845B2 Dacome AS, Da Silva CC, Da Costa CE, Fontana JD, Adelmann J, Da Costa SC (2005) Sweet diterpenic glycosides balance of a new cultivar of Stevia rebaudiana (Bert.) Bertoni: isolation and quantitative distribution by chromatographic, spectroscopic, and electrophoretic methods. Proc Biochem 40:3587–3594 Bridel M, Lavieille R (1931) The principle of sweetness (Stevia rebaudiana Bertoni) III. Diastatic hydrolysis of steviol and acid hydrolysis of isosteviol. Bull Soc Chem Biol 13:409–412 Bridel M, Lavieille R (1931) The principle of sweetness (Stevia rebaudiana Bertoni). Bull Soc Chem Biol 13:636–655 Kennelly E (2002) Sweet and non-sweet constituents of Stevia rebaudiana (Bertoni) Bertoni. Stevia, the Genus Stevia. Med Arom Plants Ind Profiles 19:68–85 Kolb N, Herrera J, Ferreyra D, Uliana R (2001) Analysis of sweet diterpene glycosides from Stevia rebaudiana: improved HPLC method. J Agric Food Chem 49:4538–4541 Geuns J (2003) Stevioside. Phytochemistry 64:913–921 Kaneda N, Kasai R, Yamasaki K, Tanaka O (1977) Chemical studies on sweet diterpene-glycosides of Stevia rebaudiana: conversion of stevioside into rebaudioside-A. Chem Pharm Bull 25:2466–2467 Kohda H, Kasai R, Yamasaki K, Murakami K, Tanaka O (1976) New sweet diterpene glucosides from Stevia rebaudiana. Phytochem 15:981–983 Sakamoto I, Yamasaki K, Tanaka O (1977) Application of 13C NMR spectroscopy to chemistry of natural glycosides: rebaudioside-C, a new sweet diterpene glycoside of Stevia rebaudiana. Chem Pharm Bull 25:844–846 Kobayashi M, Horikawa S, Degrandi IH, Mitsuhashi H, Ueno J (1977) Dulcosides A and B, new diterpene glycosides from Stevia rebaudiana. Phytochem 16:1405–1408 Ogawa T, Nozaki M, Matsui M (1980) Total synthesis of stevioside. Tetrahedron 36:2641–2648 Tanaka O (1982) Steviol-glycosides: new natural sweeteners. Trends Anal Chem 1:246–248 Kinghorn A, Nanayakkara NPD, Soejarto D, Medon P, Kamath S (1982) Potential sweetening agents of plant origin: I. Purification of Stevia rebaudiana sweet constituents by droplet counter-current chromatography. J Chromatogr 237:478–483 Fullas F, Kim J, Compadre CM, Douglas Kinghorn A (1989) Separation of natural product sweetening agents using overpressured layer chromatography. J Chromatogr 464:213–219 Liu J, Li S (1995) Separation and determination of Stevia sweeteners by capillary electrophoresis and high performance liquid chromatography. J Liq Chromatogr 18:1703–1719 Mizukami H, Shiiba K, Ohashi H (1982) Enzymatic determination of stevioside in Stevia rebaudiana. Phytochem 21:1927–1930 Nikolova-Damyanova B, Bankova V, Popov S (1994) Separation and quantitation of stevioside and rebaudioside a in plant extracts by normal-phase high performance liquid chromatography and thin-layer chromatography: a comparison. Phytochem Anal 5:81–85 Kasai R, Yamaguchi H, Tanaka O (1987) High-performance liquid chromatography of glycosides on a new type of hydroxyapatite column. J Chromatogr 407:205–210 Hashimoto Y, Moriyasu M, Nakamura S, Ishiguro S, Komuro M (1978) High-performance liquid chromatographic determination Stevia components on a hydrophilic packed column. J Chromatogr 161:403–405 Ahmed M, Dobberstein R (1982) Stevia rebaudiana: II. High–performance liquid chromatographic separation and quantitation of stevioside, rebaudioside A and rebaudioside C. J Chromatogr 236:519–522 Ahmed M, Dobberstein R, Farnsworth N (1980) Stevia rebaudiana: I. Use of p-bromophenacyl bromide to enhance ultraviolet detection of water-soluble organic acids (steviolbioside and rebaudioside B) in high-performance liquid chromatographic analysis. J Chromatogr 192:387–393 Chang SS, Cook JM (1983) Stability studies of stevioside and rebaudioside A in carbonated beverages. J Agric Food Chem 31:409–412 Kolb N, Herrera J, Ferreyra D, Uliana R (2001) Analysis of sweet diterpene glycosides from Stevia rebaudiana: Improved HPLC method. J Agric Food Chem 49:4538–4541 Vaněk T, Nepovím A, Valíček P (2001) Determination of stevioside in plant material and fruit teas. J Food Compos Anal 14:383–388 Choi YH, Kim I, Yoon KD, Lee SJ, Kim CY, Yoo K-P, Choi Y-H, Kim J (2002) Supercritical fluid extraction and liquid chromatographic-electrospray mass spectrometric analysis of stevioside from Stevia rebaudiana leaves. Chromatographia 55:617–620 Minne VJ, Compernolle F, Toppet S, Geuns JM (2004) Steviol quantification at the picomole level by high-performance liquid chromatography. J Agric Food Chem 52:2445–2449 Rajasekaran T, Ramakrishna A, Udaya Sankar K, Giridhar P, Ravishankar G (2008) Analysis of predominant steviosides in Stevia rebaudiana Bertoni by liquid chromatography/electrospray ionization-mass spectrometry. Food Biotechnol 22:179–188 Jaitak V, Bandna BS, Kaul V (2009) An efficient microwave-assisted extraction process of stevioside and rebaudioside-A from Stevia rebaudiana (Bertoni). Phytochem Anal 20:240–245 EdP Moraes, Machado NRCF (2008) Clarification of Stevia rebaudiana (Bert.) Bertoni extract by adsorption in modified zeolites. Acta SciTechnol 23:1375–1380 Yoda SK, Marques MO, Petenate AJ, Meireles MAA (2003) Supercritical fluid extraction from Stevia rebaudiana Bertoni using CO and CO+ water: extraction kinetics and identification of extracted components. J Food Eng 57:125–134 Pól J, Ostrá EV, Karásek P, Roth M, Benešová K, Kotlaříková P, Čáslavský J (2007) Comparison of two different solvents employed for pressurised fluid extraction of stevioside from Stevia rebaudiana: methanol versus water. Anal Bioanal Chem 388:1847–1857 Teo CC, Tan SN, Yong JWH, Hew CS, Ong ES (2009) Validation of green-solvent extraction combined with chromatographic chemical fingerprint to evaluate quality of Stevia rebaudiana Bertoni. J Sep Sci 32:613–622 Huang X-Y, Fu J-F, Di D-L (2010) Preparative isolation and purification of steviol glycosides from Stevia rebaudiana Bertoni using high-speed counter-current chromatography. Sep Purif Technol 71:220–224 Liu J, J-w Li, Tang J (2010) Ultrasonically assisted extraction of total carbohydrates from Stevia rebaudiana Bertoni and identification of extracts. Food Bioprod Process 88:215–221 Puri M, Sharma D, Tiwari AK (2011) Downstream processing of stevioside and its potential applications. Biotech adv 29:781–791 Choudhari SM, Ananthanarayan L (2007) Enzyme aided extraction of lycopene from tomato tissues. Food Chem 102:77–81 Li S, Li W, Xiao Q-y, Xia Y (2012) Transglycosylation of stevioside to improve the edulcorant quality by lower substitution using cornstarch hydrolyzate and CGTase. Food Chem 138:2064–2069 Ye F, Yang R, Hua X, Shen Q, Zhao W, Zhang W (2012) Modification of stevioside using transglucosylation activity of Bacillus amyloliquefaciens α-amylase to reduce its bitter aftertaste. LWT-Food Science and Technology 51:524–530 Musa A, Miao M, Zhang T, Jiang B (2014) Biotransformation of stevioside by Leuconostoc citreum SK24. 002 alternansucrase acceptor reaction. Food Chem 146:23–29 Elkins R (1997) Stevia: nature’s sweetener. Woodland Publishing, California Kroyer G (2010) Stevioside and Stevia-sweetener in food: application, stability and interaction with food ingredients. J. Verbr. Lebensm. 5:225–229 Parpinello GP, Versari A, Castellari M, Galassi S (2001) Stevioside as a replacement of sucrose in peach juice: sensory evaluation. J Sens Stud 16:471–484 Prakash I, Upreti M, Dubois G, King G, Klucik J, San Miguel R (2008) Sweetness enhancers, sweetness enhanced sweetener compositions, methods for their formulation, and uses. In: WO Patent 2,008,147,727 Prakash I, Upreti M (2008) Stevioside polymorphic and amorphous forms, methods for their formulation, and uses. In: WO Patent 2,008,147,725 De S, Mondal S, Banerjee S (2013) Stevioside: technology, applications and health. Wiley, New York Lindsay R (2007) Coke teams up with Cargill to launch new sweetener. Times, online, May 31 Goyal S, Goyal R (2010) Stevia (Stevia rebaudiana) a bio-sweetener: a review. Int J Food Sci Nutr 61:1–10 Jayaraman S, Manoharan MS, Illanchezian S (2008) In-vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts. Trop J Pharmaceut Res 7:1143–1149 Tadhani M, Subhash R (2006) Preliminary studies on Stevia rebaudiana leaves: proximal composition, mineral analysis and phytochemical screening. J. Med. Sci 6:321–326 Koyama E, Kitazawa K, Ohori Y, Izawa O, Kakegawa K, Fujino A, Ui M (2003) In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. Food Chem Toxicol 41:359–374 Hossain MA, Siddique A, Mizanur Rhaman S, Hossain A (2010) Chemical composition of the essential oils of Stevia rebaudiana Bertoni leaves. Asian J Trad Med 5:56–61 Puri M, Sharma D (2011) Antibacterial activity of stevioside towards food-borne pathogenic bacteria. Eng Life Sci 11:326–329 Tadhani MB, Subhash R (2006) In vitro antimicrobial activity of Stevia Rebaudiana Bertoni leaves. Trop J Pharm Res 5:557–560 Jayaraman S, Manoharan MS, Illanchezian S (2008) In-vitro antimicrobial and antitumor activities of Stevia Rebaudiana (Asteraceae) leaf extracts trop. J Pharm Res 7:1143–1149 Ghosh S, Subudhi E, Nayak S (2008) Antimicrobial assay of Stevia rebaudiana Bertoni leaf extracts against 10 pathogens. Int J Integr Biol 2:27 Lisak K, Lenc M, Jeličić I, Božanić R (2012) Sensory evaluation of the strawberry flavored yoghurt with stevia and sucrose addition. Hrvatski časopis za prehrambenu tehnologiju, biotehnologiju i nutricionizam 7:39–43 Saniah K, Samsiah MS (2012) The application of Stevia as sugar substitute in carbonated drinks using response surface methodology. J Trop Agric and Fd Sc 40:23–34 Carvalho ACGd, Oliveira RCGd, Navacchi MFP, Costa CEMd, Mantovani D, Dacôme AS, Seixas FAV, Costa SCd (2013) Evaluation of the potential use of rebaudioside-A as sweetener for diet jam. Food Sci Technol (Campinas) 33:555–560 Palazzo A, Carvalho M, Efraim P, Bolini H (2011) The determination of isosweetness concentrations of sucralose, rebaudioside and neotame as sucrose substitutes in new diet chocolate formulations using the time-intensity analysis. J Sens Stud 26:291–297 Ramakrishna A, Ravishankar GA (2013) Diterpene Sweeteners (Steviosides). In: Ramawat KG, Mérillon JM (eds) Natural products. Springer, Berlin, pp 3193–3203 Geuns J, Augustijns P, Mols R, Buyse JG, Driessen B (2003) Metabolism of stevioside in pigs and intestinal absorption characteristics of stevioside, rebaudioside A and steviol. Food Chem Toxicol 41:1599–1607 Geuns JM, Malheiros RD, Moraes VM, Decuypere EM-P, Compernolle F, Buyse JG (2003) Metabolism of stevioside by chickens. J Agric Food Chem 51:1095–1101 Koyama E, Sakai N, Ohori Y, Kitazawa K, Izawa O, Kakegawa K, Fujino A, Ui M (2003) Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans. Food Chem Toxicol 41:875–883 Wasuntarawat C, Temcharoen P, Toskulkao C, Mungkornkarn P, Suttajit M, Glinsukon T (1998) Developmental toxicity of steviol, a metabolite of stevioside, in the hamster. Drug Chem Toxicol 21:207–222 Chan P, Tomlinson B, Chen YJ, Liu JC, Hsieh MH, Cheng JT (2000) A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 50:215–220 Liu J-C, Kao P-K, Chan P, Hsu Y-H, Hou C-C, Lien G-S, Hsieh M-H, Chen Y-J, Cheng J-T (2002) Mechanism of the antihypertensive effect of stevioside in anesthetized dogs. Pharmacology 67:14–20 Jeppesen PB, Gregersen S, Alstrup K, Hermansen K (2002) Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats. Phytomed 9:9–14 Hsieh M-H, Chan P, Sue Y-M, Liu J-C, Liang TH, Huang T-Y, Tomlinson B, Chow MSS, Kao P-F, Chen Y-J (2003) Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 25:2797–2808 Lee C-N, Wong K-L, Liu J-C, Chen Y-J, Cheng J-T, Chan P (2001) Inhibitory effect of stevioside on calcium influx to produce antihypertension. Planta Med 67:796–799 Jeppesen PB, Gregersen S, Poulsen C, Hermansen K (2000) Stevioside acts directly on pancreatic β cells to secrete insulin: actions independent of cyclic adenosine monophosphate and adenosine triphosphate—sensitive K+-channel activity. Metabolism 49:208–214 Yasukawa K, Kitanaka S, Seo S (2002) Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Biol Pharm Bull 25:1488–1490 Atteh J, Onagbesan O, Tona K, Decuypere E, Geuns J, Buyse J (2008) Evaluation of supplementary stevia (Stevia rebaudiana, bertoni) leaves and stevioside in broiler diets: effects on feed intake, nutrient metabolism, blood parameters and growth performance. J Anim Physiol Anim Nutr 92:640–649 Geeraert B, Crombe F, Hulsmans M, Benhabiles N, Geuns J, Holvoet P (2009) Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice. Int J Obes 34:569–577 de Slavutzky SMB (2010) Stevia and sucrose effect on plaque formation. J Verbr Lebensm 5:213–216 Geuns J (2002) Safety evaluation of Stevia and stevioside. Stud Nat Prod Chem 27:299–319 Huxtable RJ (2002) Pharmacology and toxicology of stevioside, rebaudioside A, and steviol. Stevia: The Genus Stevia. Taylor and Francis, London, Engl/New York (NY), pp 160–177 Mitsuhashi H (1976) Safety of stevioside. Tama biochemical Co. Ltd. Report on safety of Stevia, pp 9–10 Medon P, Pezzuto J, Hovanec-Brown J, Nanayakkara N, Soejarto D, Kamath S, Kinghorn A (1982) Safety assessment of some Stevia rebaudiana sweet principles. In: Fed Proc 41:1568 Toskulkac C, Chaturat L, Temcharoen P, Glinsukon T (1997) Acute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal species. Drug Chem Toxicol 20:31–44 Akashi H, Yokoyama Y (1975) Dried-leaf extracts of stevia, toxicological test. Shokuhin Kogyo 18:34–43 Aze Y, Toyoda K, Imaida K, Hayashi S, Imazawa T, Hayashi Y, Takahashi M (1991) Subchronic oral toxicity study of stevioside in F344 rats. Bull Nat Inst Hyg Sc 109:48–54 Yodyingyuad V, Bunyawong S (1991) Effect of stevioside on growth and reproduction. Hum Rep 6:158–165 Yamada A, Ohgaki S, Noda T, Shimizu M (1985) Chronic toxicity study of dietary stevia extracts in F344 rats. J Food Hyg Soc Jpn 26:169–183 Xili L, Chengjiany B, Eryi X, Reiming S, Yuengming W, Haodong S, Zhiyian H (1992) Chronic oral toxicity and carcinogenicity study of stevioside in rats. Food Chem Toxicol 30:957–965 Toyoda K, Matsui H, Shoda T, Uneyama C, Takada K, Takahashi M (1997) Assessment of the carcinogenicity of stevioside in F344 rats. Food ChemToxicol 35:597–603 Additives WF (1999) Series 42: safety evaluation of certain food additives “Stevioside’’. In: Genf, pp 119–143 Mishra P, Singh R, Kumar U, Prakash V (2010) Stevia rebaudiana–A magical sweetener. Global J Biotech & Biochem 5:62–74 Serio L (2010) The Stevia rebaudiana, an alternative sugar. Phytothérapie 8:26–32 Kaushik R, Narayanan P, Vasudevan V, Muthukumaran G, Usha A (2010) Nutrient composition of cultivated stevia leaves and the influence of polyphenols and plant pigments on sensory and antioxidant properties of leaf extracts. J Food Sci Technol 47:27–33 Wood JRHB, Allerton R, Diehl HW, Fletcher HG Jr (1955) Stevioside. I. The structure of the glucose moieties. J Org Chem 20:875–883 Erkucuk A, Akgun I, Yesil-Celiktas O (2009) Supercritical CO2 extraction of glycosides from Stevia rebaudiana leaves: identification and optimization. J Supercrit Fluids 51:29–35 Liu J, Ong C, Li S (1997) Subcritical fluid extraction of Stevia sweeteners from Stevia rebaudiana. J Chromatogr Sci 35:446–450 Puri M, Kaur A, Schwarz WH, Singh S, Kennedy J (2011) Molecular characterization and enzymatic hydrolysis of naringin extracted from kinnow peel waste. Int J Biol Macromol 48:58–62 Jung S-W, Kim T-K, Lee K-W, Lee Y-H (2007) Catalytic properties of β-cyclodextrin glucanotransferase from alkalophilicBacillus sp. BL-12 and intermolecular transglycosylation of stevioside. Biotechnol Bioprocess Eng 12:207–212 Ye F, Yang R, Hua X, Shen Q, Zhao W, Zhang W (2014) Modification of steviol glycosides using α-amylase. LWT—Food Sci Technol. doi:10.1016/j.lwt.2013.12.045 Kochikyan V, Markosyan A, Abelyan L, Balayan A, Abelyan V (2006) Combined enzymatic modification of stevioside and rebaudioside A. Appl Biochem Microbiol 42:31–37