Stereotactic Irradiation of GH-Secreting Pituitary Adenomas

International Journal of Endocrinology - Tập 2012 - Trang 1-7 - 2012
Giuseppe Minniti1,2, Claudia Scaringi2, Dante Amelio3, R. Maurizi Enrici2
1Department of Neuroscience, Neuromed Institute, 86077 Pozzilli, Italy
2Department of Radiation Oncology, Sant’Andrea Hospital, University Sapienza, 00189 Rome, Italy
3ATreP, Agenzia Provinciale per la Protonterapia, 38122 Trento, Italy

Tóm tắt

Radiotherapy (RT) is often employed in patients with acromegaly refractory to medical and/or surgical interventions in order to prevent tumour regrowth and normalize elevated GH and IGF-I levels. It achieves tumour control and hormone normalization up to 90% and 70% of patients at 10–15 years. Despite the excellent tumour control, conventional RT is associated with a potential risk of developing late toxicity, especially hypopituitarism, and its role in the management of patients with GH-secreting pituitary adenomas remains a matter of debate. Stereotactic techniques have been developed with the aim to deliver more localized irradiation and minimize the long-term consequences of treatment, while improving its efficacy. Stereotactic irradiation can be given in a single dose as stereotactic radiosurgery (SRS) or in multiple doses as fractionated stereotactic radiotherapy (FSRT). We have reviewed the recent published literature on stereotactic techniques for GH-secreting pituitary tumors with the aim to define the efficacy and potential adverse effects of each of these techniques.

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International Journal of Endocrinology

Tập 2012

1-7

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