Stereochemistry‐Activity Relationships in Olfaction. Odorants containing a proton donor/proton acceptor unit

Helvetica Chimica Acta - Tập 63 Số 1 - Trang 76-94 - 1980
Günther Ohloff1, Wolfgang Giersch1
1Firmenich SA, Research Laboratories, CH–1211 Geneva 8

Tóm tắt

Abstract

A novel class of odorants is described where the odor is associated with the interaction of two functional groups, one being an H‐donor (AH function), and the other an H‐acceptor (B function). Generally, odor occurs only if the distance between the two structural elements (AH/B system) is less than 3 Å. Bifunctional derivatives of the p‐menthane and iridane series served as models for deriving this rule. The stereospecificity of odor perception was an important prerequisite for its establishment.

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Helvetica Chimica Acta

Tập 63 Số 1

76-94

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