Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

American Association for the Advancement of Science (AAAS) - Tập 264 Số 5155 - Trang 95-98 - 1994
Zhong Zhong1, Zilong Wen1, James Darnell1
1Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021

Tóm tắt

The STAT family of proteins carries out a dual function: signal transduction and activation of transcription. A new family member, Stat3, becomes activated through phosphorylation on tyrosine as a DNA binding protein in response to epidermal growth factor (EGF) and interleukin-6 (IL-6) but not interferon γ (IFN-γ). It is likely that this phosphoprotein forms homodimers as well as heterodimers with the first described member of the STAT family, Stat91 (renamed Stat1 α), which is activated by the IFNs and EGF. Differential activation of different STAT proteins in response to different ligands should help to explain specificity in nuclear signaling from the cell surface.

Từ khóa


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