Stage of hepatocellular carcinoma is associated with periodontitis

Journal of Clinical Periodontology - Tập 38 Số 11 - Trang 1015-1020 - 2011
Naofumi Tamaki1, Akinobu Takaki2, Takaaki Tomofuji3,4,5,1,6, Yasumasa Endo1, Kenta Kasuyama1, Daisuke Ekuni1, Tetsuya Yasunaka2, Kazuhide Yamamoto2, Manabu Morita1
1Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
2Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
3Address:
4Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho
5Kita-ku, Okayama 700-8558, Japan
6T. Tomofuji

Tóm tắt

AbstractAim

Periodontitis induces overproduction of reactive oxygen species (ROS). This state increases circulating ROS levels and may affect hepatocellular carcinoma (HCC). The Japan Integrated Stage (JIS) score is a novel staging system for HCC. The objective of the present study was to compare JIS scores in HCC patients with and without periodontitis.

Material and Methods

We recruited 64 HCC patients comprising 31 chronic periodontitis subjects (HCC + P) and 33 periodontally healthy controls (HCC + H). Their JIS scores were recorded. Serum levels of reactive oxygen metabolites (ROM) from HCC + P, HCC + H and healthy age‐ and gender‐matched subjects with healthy gingiva (control, n = 15) were also assessed for circulating ROS levels.

Results

The HCC + P and HCC + H groups had similar body mass index, habitual drinking and tobacco exposure data. The HCC + P group showed higher JIS scores than the HCC + H group (p = 0.027). Both the HCC + P and HCC + H groups had higher serum levels of ROM than controls (p < 0.001), while serum levels of ROM in the HCC + P group were a further 25.8% higher than those in the HCC + H group (p < 0.001).

Conclusion

HCC patients with periodontitis had higher JIS score and circulating ROS level than HCC patients without periodontitis.

Từ khóa


Tài liệu tham khảo

10.1111/j.1600-051X.2007.01091.x

10.1016/S0899-9007(01)00521-4

10.1016/j.archoralbio.2008.02.002

10.1111/j.1600-051X.2006.00923.x

10.1111/j.1600-051X.1997.tb00760.x

10.1111/j.1600-0757.2006.00178.x

10.1111/j.1872-034X.2007.00187.x

10.1177/0022034510375830

10.1111/j.1600-0757.2009.00326.x

10.3109/00016350903291913

10.1016/S1047-2797(02)00425-8

Inokuma T., 2009, Oxidative stress and tumor progression in colorectal cancer, Hepato‐Gastroenterology, 56, 343

International Union Against Cancer (UICC), 2002, TNM Classification of Malignant Tumours, 81

10.2209/tdcpublication.51.139

Konopka T., 2007, Total antioxidant status and 8‐hydroxy‐2′‐deoxyguanosine levels in gingival and peripheral blood of periodontitis patients, Arch Immunologiae et Therapiae Experiementalis (Watsz), 55, 1

10.1002/hep.20486

10.1007/s00535-008-2164-y

10.1111/j.1600-051X.2005.00821.x

10.1634/theoncologist.2010-S4-23

Ohyama H., 2009, An unusual autopsy case of pyogenic liver abscess caused by periodontal bacteria, Japanese Journal of Infectious Disease, 62, 381

10.1016/j.cca.2009.06.038

Panjamurthy K., 2005, Lipid peroxidation and antioxidant status in patients with periodontitis, Cellular and Molecular Biology Letters, 10, 255

10.1002/bjs.1800600817

10.1177/00220345010800070701

Saito T., 2006, Relationship between periodontitis and hepatic condition in Japanese women, Journal of the Internartional Academy of Periodontology, 8, 89

10.1079/PNS2001141

10.1038/aps.2010.142

10.3109/00016356408993968

10.1111/j.1600-0765.2010.01273.x

10.1007/s00784-010-0458-y

10.1902/jop.2009.080640

10.1902/jop.2008.080082

10.1136/gut.2003.035055

10.1158/1055-9965.EPI-09-0334

10.1001/archotol.133.5.450

10.1902/jop.2007.070056

10.1016/j.archoralbio.2008.05.015

10.1111/j.1572-0241.2005.41943.x

10.1258/acb.2009.009029

10.1111/j.1600-051X.2010.01663.x

10.1111/j.1834-7819.2009.01123.x

Thông tin
Thông tin xuất bản

Journal of Clinical Periodontology

Tập 38 Số 11

1015-1020

Thông tin tác giả